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Author Gulotta, M.; Rogatsky, E.; Callender, R.H.; Dyer, R.B. openurl 
  Title Primary folding dynamics of sperm whale apomyoglobin: core formation Type Journal Article
  Year 2003 Publication (up) Biophysical Journal Abbreviated Journal Biophys J  
  Volume 84 Issue 3 Pages 1909-1918  
  Keywords Animals; Apoproteins/*chemistry; Crystallography/*methods; Horses; Myocardium/chemistry; Myoglobin/*chemistry; Protein Conformation; *Protein Folding; Species Specificity; Structure-Activity Relationship; Temperature; Whales  
  Abstract The structure, thermodynamics, and kinetics of heat-induced unfolding of sperm whale apomyoglobin core formation have been studied. The most rudimentary core is formed at pH(*) 3.0 and up to 60 mM NaCl. Steady state for ultraviolet circular dichroism and fluorescence melting studies indicate that the core in this acid-destabilized state consists of a heterogeneous composition of structures of approximately 26 residues, two-thirds of the number involved for horse heart apomyoglobin under these conditions. Fluorescence temperature-jump relaxation studies show that there is only one process involved in Trp burial. This occurs in 20 micro s for a 7 degrees jump to 52 degrees C, which is close to the limits placed by diffusion on folding reactions. However, infrared temperature jump studies monitoring native helix burial are biexponential with times of 5 micro s and 56 micro s for a similar temperature jump. Both fluorescence and infrared fast phases are energetically favorable but the slow infrared absorbance phase is highly temperature-dependent, indicating a substantial enthalpic barrier for this process. The kinetics are best understood by a multiple-pathway kinetics model. The rapid phases likely represent direct burial of one or both of the Trp residues and parts of the G- and H-helices. We attribute the slow phase to burial and subsequent rearrangement of a misformed core or to a collapse having a high energy barrier wherein both Trps are solvent-exposed.  
  Address Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA. gulotta@aecom.yu.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0006-3495 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:12609893 Approved no  
  Call Number Equine Behaviour @ team @ Serial 3783  
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Author Abbruzzetti, S.; Crema, E.; Masino, L.; Vecli, A.; Viappiani, C.; Small, J.R.; Libertini, L.J.; Small, E.W. openurl 
  Title Fast events in protein folding: structural volume changes accompanying the early events in the N-->I transition of apomyoglobin induced by ultrafast pH jump Type Journal Article
  Year 2000 Publication (up) Biophysical Journal Abbreviated Journal Biophys J  
  Volume 78 Issue 1 Pages 405-415  
  Keywords Animals; Apoproteins/*chemistry; Horses; *Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Myoglobin/*chemistry; Protein Conformation; *Protein Folding; Protein Structure, Secondary; Spectrometry, Fluorescence  
  Abstract Ultrafast, laser-induced pH jump with time-resolved photoacoustic detection has been used to investigate the early protonation steps leading to the formation of the compact acid intermediate (I) of apomyoglobin (ApoMb). When ApoMb is in its native state (N) at pH 7.0, rapid acidification induced by a laser pulse leads to two parallel protonation processes. One reaction can be attributed to the binding of protons to the imidazole rings of His24 and His119. Reaction with imidazole leads to an unusually large contraction of -82 +/- 3 ml/mol, an enthalpy change of 8 +/- 1 kcal/mol, and an apparent bimolecular rate constant of (0.77 +/- 0.03) x 10(10) M(-1) s(-1). Our experiments evidence a rate-limiting step for this process at high ApoMb concentrations, characterized by a value of (0. 60 +/- 0.07) x 10(6) s(-1). The second protonation reaction at pH 7. 0 can be attributed to neutralization of carboxylate groups and is accompanied by an apparent expansion of 3.4 +/- 0.2 ml/mol, occurring with an apparent bimolecular rate constant of (1.25 +/- 0.02) x 10(11) M(-1) s(-1), and a reaction enthalpy of about 2 kcal/mol. The activation energy for the processes associated with the protonation of His24 and His119 is 16.2 +/- 0.9 kcal/mol, whereas that for the neutralization of carboxylates is 9.2 +/- 0.9 kcal/mol. At pH 4.5 ApoMb is in a partially unfolded state (I) and rapid acidification experiments evidence only the process assigned to carboxylate protonation. The unusually large contraction and the high energetic barrier observed at pH 7.0 for the protonation of the His residues suggests that the formation of the compact acid intermediate involves a rate-limiting step after protonation.  
  Address Dipartimento di Fisica, Universita di Parma, 43100 Parma, Italia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0006-3495 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:10620304 Approved no  
  Call Number Equine Behaviour @ team @ Serial 3792  
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Author Gonzalez-Fernandez, J.M.; Atta, S.E. openurl 
  Title Facilitated transport of oxygen in the presence of membranes in the diffusion path Type Journal Article
  Year 1982 Publication (up) Biophysical Journal Abbreviated Journal Biophys J  
  Volume 38 Issue 2 Pages 133-141  
  Keywords Animals; Biological Transport, Active; Cell Membrane/*metabolism; Diffusion; Dogs; Horses; Humans; Kinetics; Mathematics; *Models, Biological; Muscles/*metabolism; Oxygen/*metabolism  
  Abstract Most of the experimental observations on facilitated transport have been done with millipore filters, and all the theoretical studies have assumed homogeneous spatial properties. In striated muscle there exist membranes that may impede the diffusion of the carrier myoglobin. In this paper a theoretical study is undertaken to analyze the transport in the presence of membranes in the diffusion path. For the numerical computations physiologically relevant values of the parameters were chosen. The numerical results indicate that the presence of membranes tends to decrease the facilitation. For the nonlinear chemical kinetics of the reaction of oxygen with the carrier, this decrement also depends on the location of the membranes. At the higher oxygen concentration side of each membrane the flow of combined oxygen is transferred to the flow of dissolved oxygen. The reverse process occurs at the lower concentration side. Jump discontinuities of the concentration of the oxygen-carrier compound at each membrane are associated with these transfers. The decrement of facilitation is due to the cumulative effect of these jump discontinuities.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0006-3495 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:7093418 Approved no  
  Call Number Equine Behaviour @ team @ Serial 3806  
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Author Cancedda, M. openurl 
  Title [Social and behavioral organization of horses on the Giara (Sardinia): distribution and aggregation] Type Journal Article
  Year 1990 Publication (up) Bollettino della Societa italiana di biologia sperimentale Abbreviated Journal Boll Soc Ital Biol Sper  
  Volume 66 Issue 11 Pages 1089-1096  
  Keywords Animals; *Animals, Wild/physiology/psychology; Environment; Female; *Horses/physiology/psychology; Italy; Male; Population Density; Sexual Behavior, Animal; *Social Behavior; Social Dominance; Water  
  Abstract In this paper some considerations on the environment of the 42 Kmq of the volcanic-basaltic Giara tableland are discussed. Conditioning by the environment and its effect on the distribution of a population of 712 horses is illustrated in view of their social and behavioural organization.  
  Address Istituto di Fisiologia Generale e Speciale, Universita di Sassari  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Italian Summary Language Original Title Introduzione all'organizzazione sociale e comportamentale dei cavallini sulla Giara (Sardegna): distribuzione ed aggregazione  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0037-8771 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2095819 Approved no  
  Call Number refbase @ user @ Serial 673  
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Author Verheyen, K.; Price, J.; Lanyon, L.; Wood, J. doi  openurl
  Title Exercise distance and speed affect the risk of fracture in racehorses Type Journal Article
  Year 2006 Publication (up) Bone Abbreviated Journal Bone  
  Volume 39 Issue 6 Pages 1322-1330  
  Keywords Animals; Case-Control Studies; Cohort Studies; England; Exertion; Female; Fractures, Bone/etiology/*veterinary; Horse Diseases/*etiology; Horses/*injuries; Male; Physical Conditioning, Animal/adverse effects/methods; Poisson Distribution; Prospective Studies; Regression Analysis; Risk Factors; Running/injuries/physiology  
  Abstract In order to gain insight into those training regimens that can minimise the risk of fracture in athletic populations, we conducted a large epidemiological study in racehorses. Thoroughbred racehorses provide a suitable model for studying fracture development and exercise-related risk factors in physically active populations. They represent a homogeneous population, undertaking intensive exercise programmes that are sufficiently heterogeneous to determine those factors that influence injury risk. Daily exercise information was recorded for a cohort of 1178 thoroughbreds that were monitored for up to 2 years. A total of 148 exercise-induced fractures occurred in the study population. Results from a nested case-control study showed a strong interactive effect of exercise distances at different speeds on fracture risk. Horses that exceeded 44 km at canter (< or =14 m/s) and 6 km at gallop (>14 m/s) in a 30-day period were at particularly increased risk of fracture. These distances equate to ca. 7700 bone loading cycles at canter and 880 loading cycles at gallop. Fifty-six fractures occurred in the subset of study horses that were followed since entering training as yearlings, when skeletally immature (n = 335). Cohort analysis of this data set showed that, in previously untrained bones, accumulation of canter exercise increased the risk of fracture (P < or = 0.01), whereas accumulation of high-speed gallop exercise had a protective effect (P < 0.01). However, increasing distances at canter and gallop in short time periods (up to one month) were associated with an increasing fracture risk. All training exercise involves a balance between the risk of fracture inherent in exposure to loading and the beneficial effect that loading has by stimulating bone cells to produce a more robust architecture. Results from our study provide important epidemiological evidence of the effects of physical exercise on bone adaptation and injury risk and can be used to inform the design of safer exercise regimens in physically active populations.  
  Address Epidemiology Unit, Animal Health Trust, Newmarket, United Kingdom. kverheyen@rvc.ac.uk  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 8756-3282 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16926125 Approved no  
  Call Number Equine Behaviour @ team @ Serial 4030  
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Author Lees, P.; Tavernor, W.D. openurl 
  Title Influence of halothane and catecholamines on heart rate and rhythm in the horse Type Journal Article
  Year 1970 Publication (up) British journal of pharmacology Abbreviated Journal Br J Pharmacol  
  Volume 39 Issue 1 Pages 149-159  
  Keywords Anesthesia, Inhalation; Animals; Arrhythmia/*chemically induced; Atropine/pharmacology; Catecholamines/*pharmacology; Consciousness; Epinephrine/administration & dosage; Ethers; Female; Halothane/*pharmacology; Heart Rate/*drug effects; Horses; Hypercapnia/physiopathology; Isoproterenol/pharmacology; Male; Norepinephrine/pharmacology; Propranolol/pharmacology  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-1188 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:5420092 Approved no  
  Call Number refbase @ user @ Serial 103  
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Author Alexander, F. openurl 
  Title The effect of diuretics on the faecal excretion of water and electrolytes in horses Type Journal Article
  Year 1977 Publication (up) British journal of pharmacology Abbreviated Journal Br J Pharmacol  
  Volume 60 Issue 4 Pages 589-593  
  Keywords Animals; Body Water/*metabolism; Chlorides/metabolism; Electrolytes/*metabolism; Feces/*analysis; Furosemide/*pharmacology; Horses; Hydrochlorothiazide/*pharmacology; Male; Potassium/metabolism; Sodium/metabolism; Time Factors  
  Abstract 1. The effect on plasma, urinary and faecal electrolytes of frusemide and hydrochlorthiazide was measured in ponies, mean weight 180 kg. 2. The rapid loss in urine of large quantities of sodium had only a small effect on plasma sodium concentration. 3. Faecal sodium excretion was increased substantially after the administration of frusemide. 4. Frusemide increased faecal potassium during the 48 h following administration and faecal water in the 24/48 h period. It also produced a hypopotassaemia. 5. Hydrochlorthiazide increased faecal chloride during the 24 h after administration. 6. Frusemide increased the intestinal transit time of both liquid (polyethylene glycol) and particulate (Cr2O3) markers.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-1188 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:907872 Approved no  
  Call Number refbase @ user @ Serial 111  
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Author Alexander, F.; Collett, R.A. openurl 
  Title Proceedings: Some observations on the pharmacokinetics of trimethoprim in the horse Type Journal Article
  Year 1974 Publication (up) British journal of pharmacology Abbreviated Journal Br J Pharmacol  
  Volume 52 Issue 1 Pages 142p  
  Keywords Animals; Half-Life; Horses/*metabolism; Kinetics; Trimethoprim/*metabolism  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-1188 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:4451793 Approved no  
  Call Number refbase @ user @ Serial 112  
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Author Thomas, K.E.; Annest, J.L.; Gilchrist, J.; Bixby-Hammett, D.M. doi  openurl
  Title Non-fatal horse related injuries treated in emergency departments in the United States, 2001-2003 Type
  Year 2006 Publication (up) British Journal of Sports Medicine Abbreviated Journal Br J Sports Med  
  Volume 40 Issue 7 Pages 619-626  
  Keywords Accident Prevention/methods; Accidental Falls/prevention & control; Adolescent; Adult; Aged; Animals; Athletic Injuries/*epidemiology/prevention & control; Child; Child, Preschool; Emergency Service, Hospital/*statistics & numerical data; Female; Head Protective Devices/utilization; Health Promotion; *Horses; Humans; Infant; Male; Middle Aged; Patient Education; Sex Distribution; United States/epidemiology  
  Abstract OBJECTIVE: To characterise and provide nationally representative estimates of persons with non-fatal horse related injuries treated in American emergency departments. METHODS: The National Electronic Injury Surveillance System All Injury Program (NEISS-AIP) is a stratified probability sample comprising 66 hospitals. Data on injuries treated in these emergency departments are collected and reported. NEISS-AIP data on all types (horseback riding and otherwise) of non-fatal horse related injuries from 2001 to 2003 were analysed. RESULTS: An estimated 102,904 persons with non-fatal horse related injuries (35.7 per 100,000 population) were treated in American emergency departments each year from 2001 to 2003 inclusive. Non-fatal injury rates were higher for females (41.5 per 100,000) than for males (29.8 per 100,000). Most patients were injured while mounted on a horse (66.1%), commonly from falling or being thrown by the horse; while not mounted, injuries most often resulted from being kicked by the horse. The body parts most often injured were the head/neck region (23.2%), lower extremity (22.2%), and upper extremity (21.5%). The most common principal diagnoses were contusions/abrasions (31.4%) and fractures (25.2%). For each year that was studied, an estimated 11 502 people sustained traumatic brain injuries from horse related incidents. Overall, more than 11% of those injured were admitted to hospital. CONCLUSIONS: Horse related injuries are a public health concern not just for riders but for anyone in close contact with horses. Prevention programmes should target horseback riders and horse caregivers to promote helmet use and educate participants about horse behaviour, proper handling of horses, and safe riding practices.  
  Address Office of Statistics and Programming, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. KEThomas@cdc.gov  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1473-0480 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16611723 Approved no  
  Call Number Serial 1866  
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Author Gutierrez Rincon, J.A.; Vives Turco, J.; Muro Martinez, I.; Casas Vaque, I. openurl 
  Title A comparative study of the metabolic effort expended by horse riders during a jumping competition Type Journal Article
  Year 1992 Publication (up) British Journal of Sports Medicine Abbreviated Journal Br J Sports Med  
  Volume 26 Issue 1 Pages 33-35  
  Keywords Adult; Animals; Energy Metabolism/*physiology; *Exertion; Heart Rate/physiology; Horses; Humans; Lactates/blood; *Sports  
  Abstract The three main Olympic horse riding disciplines are dressage, jumping, and three-day eventing (including dressage, cross country and jumping). In the jumping discipline (obstacle race), the 'team' (horse rider) is judged under the different conditions that might take place in a varied run. The horse is expected to show power and ability; the rider must show riding skill and good physical condition. However, the different conditions encountered by the rider during competition (duration of event, continuous isometric working level, especially in the inferior trunk, lead us to consider the need for a rider to develop different metabolic pathways to meet the high energy requirements of the competition.  
  Address Centre de Medicina de l'Esport de Barcelona, Spain  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0306-3674 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:1600451 Approved no  
  Call Number Equine Behaviour @ team @ Serial 3754  
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