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Author Tsong, T.Y.
Title Conformational relaxations of urea- and guanidine hydrochloride-unfolded ferricytochrome c Type Journal Article
Year 1977 Publication The Journal of Biological Chemistry Abbreviated Journal J Biol Chem
Volume 252 Issue 24 Pages 8778-8780
Keywords *Cytochrome c Group; Guanidines/*pharmacology; Protein Conformation/drug effects; Spectrometry, Fluorescence; Urea/*pharmacology
Abstract Several recent studies of protein the unfolded proteins. In urea- and guanidine HCl-unfolded ferricytochrome c (horse heart), an acid-induced spin state transformation of the heme group has been detected by the heme absorptions, Trp-59 fluorescence, and the intrinsic viscosity of protein. Kinetics of this second conformational transition, by the temperature jump and stopped flow methods, are complex. One rapid reaction (tau1), pH-independent, occurs in a 50-mus range; the second reaction (tau2), in a 1-ms range, depends linearly upon pH and is faster at the alkaline side; a third reaction (tau3), in a 1-s range, shows a sigmoidal transition at pH 5.1 and is faster at the acidic side. The results are consistent with a kinetic scheme which involves protein conformational changes in the transformation of the heme coordination state. The kinetics, along with previous equilibrium studies, indicate that ligand or charge interactions within a protein molecule are not completely prohibited even in strongly denaturing conditions, such as in high concentrations of urea and guanidine HCl. Thus, local structures of peptide chain associated with these interactions can exist in the unfolded protein.
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Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0021-9258 ISBN Medium
Area Expedition Conference
Notes (up) PMID:200618 Approved no
Call Number refbase @ user @ Serial 3882
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Author Wilson, M.T.; Ranson, R.J.; Masiakowski, P.; Czarnecka, E.; Brunori, M.
Title A kinetic study of the pH-dependent properties of the ferric undecapeptide of cytochrome c (microperoxidase) Type Journal Article
Year 1977 Publication European Journal of Biochemistry / FEBS Abbreviated Journal Eur J Biochem
Volume 77 Issue 1 Pages 193-199
Keywords Animals; Cyanides; *Cytochrome c Group/metabolism; Ferric Compounds; Horses; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Mathematics; Myocardium/enzymology; *Oligopeptides/metabolism; *Peptide Fragments/metabolism; Protein Binding; Spectrophotometry; Temperature
Abstract The ferric form of the haem undecapeptide, derived from horse cytochrome c by peptic digestion, undergoes at least three pH-induced transitions with pK values of 3.4, 5.8 and 7.6. Temperature-jump experiments suggest that the first of these is due to the binding of a deprotonated imidazole group to the feric iron while the second and third arise from the binding of the two available amino groups present (the alpha-NH2 of valine and the epsilon-NH2 of lysine). Molecular models indicate that steric retraints on the peptide dictate that these amino groups may only coordinate to iron atoms via intermolecular bonds, thus leading to the polymerization of the peptide. Cyanide binding studies are in agreement with these conclusions and also yield a value of 3.6 X 10(6) M-1 s-1 for the intrinsic combination constant of CN- anion with the haem. A model is proposed which describes the pH-dependent properties of the ferric undecapeptide.
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Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0014-2956 ISBN Medium
Area Expedition Conference
Notes (up) PMID:20304 Approved no
Call Number Equine Behaviour @ team @ Serial 3814
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Author Levy, J.
Title The mammalian brain and the adaptive advantage of cerebral asymmetry Type Journal Article
Year 1977 Publication Annals of the New York Academy of Sciences Abbreviated Journal Ann N Y Acad Sci
Volume 299 Issue Pages 264-272
Keywords *Adaptation, Physiological; Adaptation, Psychological/physiology; Animals; Behavior, Animal/physiology; Brain/*physiology; Cognition/physiology; Dominance, Cerebral/*physiology; *Evolution; Humans; Intelligence; Perception/physiology
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0077-8923 ISBN Medium
Area Expedition Conference
Notes (up) PMID:280207 Approved no
Call Number Equine Behaviour @ team @ Serial 4137
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Author Seyfarth, R.M.
Title A model of social grooming among adult female monkeys Type Journal Article
Year 1977 Publication Journal of Theoretical Biology Abbreviated Journal J. Theor. Biol.
Volume 65 Issue 4 Pages 671-698
Keywords Animals; Behavior, Animal; Female; *Grooming; Haplorhini/*physiology; *Models, Biological; Reproduction; Social Dominance; Time Factors
Abstract Grooming networks among adult female monkeys exhibit two similar features across a number of different species. High-ranking animals receive more grooming than others, and the majority of grooming occurs between females of adjacent rank. A theoretical model which duplicates these features is presented, and the properties of the model are used to explain the possible causation and function of female grooming behaviour. The model illustrates how relatively simple principles governing the behaviour of individuals may be used to explain more complex aspects of the social structure of non-human primate groups.
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Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-5193 ISBN Medium
Area Expedition Conference
Notes (up) PMID:406485 Approved no
Call Number Equine Behaviour @ team @ Serial 5259
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Author de Waal, F.B.
Title The organization of agonistic relations within two captive groups of Java-monkeys (Macaca fascicularis) Type Journal Article
Year 1977 Publication Zeitschrift für Tierpsychologie Abbreviated Journal Z. Tierpsychol.
Volume 44 Issue 3 Pages 225-282
Keywords Age Factors; Aggression; Animals; Behavior, Animal/*physiology; Competitive Behavior/*physiology; Fear; Female; Haplorhini; Humans; Macaca/*physiology; Macaca fascicularis/*physiology; Male; Sex Factors; Social Behavior; Social Dominance
Abstract The paper offers a detailed quantitative descripition of the distribution of agonistic activities over the members of two groups of Java-monkeys (Macaca fascicularis). These groups lived in captivity and were well-established: i.e. they had an extensive network of genealogical relationships. The study pays special attention to agonistic interactions with three or more participants. Its main purpose is an analysis of the way dyadic agonistic relations (e.g. dominance relations) are affected by third group members and the relations among these. The paper presents data on the ontogeny of 'dependent dominance', the 'control role' of the alpha-male, and the functions of different types of alliances.
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Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0044-3573 ISBN Medium
Area Expedition Conference
Notes (up) PMID:412345 Approved no
Call Number refbase @ user @ Serial 213
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Author Kirkpatrick, J.F.; Wiesner, L.; Kenney, R.M.; Ganjam, V.K.; Turner, J.W.
Title Seasonal variation in plasma androgens and testosterone in the North American wild horse Type Journal Article
Year 1977 Publication The Journal of endocrinology Abbreviated Journal J Endocrinol
Volume 72 Issue 2 Pages 237-238
Keywords Androgens/*blood; Animals; Horses/*blood; Male; *Seasons; Testosterone/*blood
Abstract
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Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-0795 ISBN Medium
Area Expedition Conference
Notes (up) PMID:845536 Approved no
Call Number refbase @ user @ Serial 148
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Author Rudy, J.W.; Iwens, J.; Best, P.J.
Title Pairing novel exteroceptive cues and illness reduces illness-induced taste aversions Type Journal Article
Year 1977 Publication Journal of Experimental Psychology. Animal Behavior Processes Abbreviated Journal J Exp Psychol Anim Behav Process
Volume 3 Issue 1 Pages 14-25
Keywords Animals; *Association; *Avoidance Learning; Awareness; Conditioning, Operant; *Cues; Drinking Behavior; Environment; Inhibition (Psychology); Lithium/poisoning; Male; Rats; Saccharin/pharmacology; *Taste
Abstract Four experiments are reported that lead to the conclusion that pairing novel exteroceptive stimulation (placement into a black compartment) with a poison (lithium chloride) attenuates the development of an aversion to a taste (saccharin) subsequently paired with the poison. Such an attenuation effect occurs whether the exteroceptive cues are present or absent when the taste-poison pairing is administered. Interpretation and implications of this finding are discussed.
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Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0097-7403 ISBN Medium
Area Expedition Conference
Notes (up) PMID:845542 Approved no
Call Number Equine Behaviour @ team @ Serial 2789
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Author Domjan, M.
Title Selective suppression of drinking during a limited period following aversive drug treatment in rats Type Journal Article
Year 1977 Publication Journal of Experimental Psychology. Animal Behavior Processes Abbreviated Journal J Exp Psychol Anim Behav Process
Volume 3 Issue 1 Pages 66-76
Keywords Animals; *Avoidance Learning; Awareness; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking Behavior/*drug effects; Lithium/*poisoning; Male; Osmolar Concentration; Rats; Saccharin/administration & dosage; *Taste; Time Factors
Abstract Administration of lithium chloride disrupted the intake of flavored solutions but not water in rats. This intake suppression was directly related to the amount of lithium administered (Experiment 1), occurred with both palatable and unpalatable novel saccharin solutions (Experiment 2), but was only observed if subjects were tested starting less than 75 min. after lithium treatment (Experiment 3). Twenty-five daily exposures to saccharin did not attenuate the effect (Experiment 4). However, in saccharin-reared and vinegar-reared rats, lithium did not disrupt consumption of the solutions these subjects had access to throughout life, even though suppressions of intake were observed when these subjects were tested with novel flavors (Experiment 5). The selective disruption of drinking is interpreted as a novelty-dependent sensitization reaction to the discomfort of aversive drug administration.
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Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0097-7403 ISBN Medium
Area Expedition Conference
Notes (up) PMID:845544 Approved no
Call Number Equine Behaviour @ team @ Serial 2788
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Author Adler, L.L.; Adler, H.E.
Title Ontogeny of observational learning in the dog (Canis familiaris) Type Journal Article
Year 1977 Publication Developmental Psychobiology Abbreviated Journal Dev Psychobiol
Volume 10 Issue 3 Pages 267-271
Keywords Animals; Dogs/*physiology; Female; Learning/*physiology; Male; Vision, Ocular/physiology
Abstract A split-litter technique was used to test observational learning in 4 litters of Miniature Dachshund puppies, 21, 28, 38, and 60 days old at the beginning of the experiment. In one side of a duplicate cage, one puppy of a litter, the demonstrator, learned to pull in a food cart on a runner by means of a ribbon, while another puppy, the observer, watched from an adjacent compartment, separated by a wire screen. Observational learning was demonstrated by the saving in time for the 1st trial when the observer was given the same problem to solve. Maturation, particularly the development of visual function and motor coordination, set a lower age limit for the emergence of observational learning.
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Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0012-1630 ISBN Medium
Area Expedition Conference
Notes (up) PMID:863122 Approved no
Call Number Equine Behaviour @ team @ Serial 5186
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Author Alexander, F.
Title The effect of diuretics on the faecal excretion of water and electrolytes in horses Type Journal Article
Year 1977 Publication British journal of pharmacology Abbreviated Journal Br J Pharmacol
Volume 60 Issue 4 Pages 589-593
Keywords Animals; Body Water/*metabolism; Chlorides/metabolism; Electrolytes/*metabolism; Feces/*analysis; Furosemide/*pharmacology; Horses; Hydrochlorothiazide/*pharmacology; Male; Potassium/metabolism; Sodium/metabolism; Time Factors
Abstract 1. The effect on plasma, urinary and faecal electrolytes of frusemide and hydrochlorthiazide was measured in ponies, mean weight 180 kg. 2. The rapid loss in urine of large quantities of sodium had only a small effect on plasma sodium concentration. 3. Faecal sodium excretion was increased substantially after the administration of frusemide. 4. Frusemide increased faecal potassium during the 48 h following administration and faecal water in the 24/48 h period. It also produced a hypopotassaemia. 5. Hydrochlorthiazide increased faecal chloride during the 24 h after administration. 6. Frusemide increased the intestinal transit time of both liquid (polyethylene glycol) and particulate (Cr2O3) markers.
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Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0007-1188 ISBN Medium
Area Expedition Conference
Notes (up) PMID:907872 Approved no
Call Number refbase @ user @ Serial 111
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