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Author |
Moon, C.; Baldridge, M.T.; Wallace, M.A.; Burnham, C.-A.D.; Virgin, H.W.; Stappenbeck, T.S. |
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Title |
Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation |
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Journal Article |
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Year |
2015 |
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Nature |
Abbreviated Journal |
Nature |
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Volume |
521 |
Issue |
7550 |
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90-93 |
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Keywords |
Phenotype |
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Abstract |
The proliferation of genetically modified mouse models has exposed phenotypic variation between investigators and institutions that has been challenging to control1-5. In many cases, the microbiota is the presumed culprit of the variation. Current solutions to account for phenotypic variability include littermate and maternal controls or defined microbial consortia in gnotobiotic mice6,7. In conventionally raised mice, the microbiome is transmitted from the dam2,8,9. Here we show that microbially–driven dichotomous fecal IgA levels in WT mice within the same facility mimic the effects of chromosomal mutations. We observed in multiple facilities that vertically-transmissible bacteria in IgA-Low mice dominantly lowered fecal IgA levels in IgA-High mice after cohousing or fecal transplantation. In response to injury, IgA-Low mice showed increased damage that was transferable by fecal transplantation and driven by fecal IgA differences. We found that bacteria from IgA-Low mice degraded the secretory component (SC) of SIgA as well as IgA itself. These data indicate that phenotypic comparisons between mice must take into account the non-chromosomal hereditary variation between different breeders. We propose fecal IgA as one marker of microbial variability and conclude that cohousing and/or fecal transplantation enables analysis of progeny from different dams. |
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Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA. |
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eng |
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0028-0836 |
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Equine Behaviour @ team @ |
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6005 |
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Author |
Bouman, I. |
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The reintroduction of Przewalski horses in the Hustain Nuruu Mountain Forest Steppe Reserve in Mongolia |
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1998 |
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Mededelingen: Netherlands Commission for International Nature Protection |
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32 |
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Equine Behaviour @ team @ |
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2241 |
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Author |
Marean, C.W.; Gifford-Gonzalez, D. |
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Title |
Late Quaternary extinct ungulates of East Africa and palaeoenvironmental implications |
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Journal Article |
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Year |
1991 |
Publication |
Nature |
Abbreviated Journal |
Nature |
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Volume |
350 |
Issue |
6317 |
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418-420 |
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UNGULATE communities of two East African savannas, the Serengeti and Athi-Kapiti Plains, are dominated by wildebeest (Connochaetes taurinus) supplemented by zebra (Equus burchelli), topi (Damaliscus lunatus), hartebeest (Alcelaphus buselaphus), buffalo (Syncerus caffer) eland (Taurotragus oryx) and gazelles (Gazella grand and G. thomsoni)1-3. Before this research, little was known of East African large mammal communities in the Late Pleistocene and early to middle Holocene. We document an extinct impala-sized alcelaphine antelope that is numerically dominant in Late Pleistocene archaeofaunal assemblages from the Athi-Kapiti Plains. The extinct giant buffalo Pelorovis antiquus is present, and a number of arid-adapted regionally extinct species are common. The small alcelaphine is rare in northern Tanzania, but regionally extinct arid-adapted species are present in Late Pleistocene deposits. These data indicate that as recently as 12,000 years ago, the large mammal community structure of East African savannas was very different and dry grasslands and arid-adapted ungulates expanded at least as far south as northern Tanzania during the Last Glacial Maximum. |
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10.1038/350418a0 |
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Equine Behaviour @ team @ |
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2345 |
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Author |
Kamil, A.C. |
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Title |
On the Proper Definition of Cognitive Ethology |
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Book Chapter |
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Year |
1998 |
Publication |
Animal Cognition in Nature |
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1-28 |
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Summary The last 20-30 years have seen two `scientific revolutions' in the study of animal behavior: the cognitive revolution that originated in psychology, and the Darwinian, behavioral ecology revolution that originated in biology. Among psychologists, the cognitive revolution has had enormous impact. Similarly, among biologists, the Darwinian revolution has had enormous impact. The major theme of this chapter is that these two scientific research programs need to be combined into a single approach, simultaneously cognitive and Darwinian, and that this single approach is most appropriately called cognitive ethology. |
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Academic Press |
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London |
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Russell P. Balda; Irene M. Pepperberg; Alan C. Kamil |
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9780120770304 |
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Equine Behaviour @ team @ |
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4202 |
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Author |
Packer, C. |
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Title |
Reciprocal altruism in Papio anubis |
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Journal Article |
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Year |
1977 |
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Nature |
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Nature |
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265 |
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441-445 |
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10.1038/265441a0 |
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Equine Behaviour @ team @ |
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4840 |
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Author |
Nowak, M.A.; Sigmund, K. |
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Title |
Tit for tat in heterogeneous populations |
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1992 |
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Nature |
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Nature |
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355 |
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250-253 |
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10.1038/355250a0 |
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Equine Behaviour @ team @ |
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4842 |
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Author |
Maynard Smith, J.; Price, G.R. |
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Title |
The Logic of Animal Conflict |
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1973 |
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Nature |
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Nature |
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246 |
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15-18 |
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10.1038/246015a0 |
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Equine Behaviour @ team @ |
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4844 |
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Author |
Hamilton, W.D. |
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Title |
Selfish and Spiteful Behaviour in an Evolutionary Model |
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1970 |
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Nature |
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Nature |
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228 |
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1218-1220 |
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10.1038/2281218a0 |
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Equine Behaviour @ team @ |
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4853 |
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Author |
Reeve, H.K. |
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Title |
Queen activation of lazy workers in colonies of the eusocial naked mole-rat |
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Year |
1992 |
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Nature |
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Nature |
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358 |
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147-149 |
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10.1038/358147a0 |
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Equine Behaviour @ team @ |
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4921 |
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Author |
Virányi, Zs.; Range, F.; Huber, L. |
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Title |
Attentiveness toward others and social learning in domestic dogs. |
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2008 |
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Learning from Animals?: Examining the Nature of Human Uniqueness |
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141-154 |
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Psychology Press |
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New York, NY |
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Röska-hardy,L.S.. ;Neumann-held, E. |
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978-1-84169-707-9 |
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Equine Behaviour @ team @ |
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4974 |
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