| |
Records |
Links |
|
Author |
Cowell, P.E.; Fitch, R.H.; Denenberg, V.H. |
|
| |
Title |
Laterality in animals: relevance to schizophrenia |
Type |
Journal Article |
| |
Year |
1999 |
Publication |
Schizophrenia Bulletin |
Abbreviated Journal |
Schizophr Bull |
|
| |
Volume |
25 |
Issue |
1 |
Pages |
41-62 |
|
| |
Keywords |
Adult; Animals; Cognition; *Disease Models, Animal; Functional Laterality/*physiology; Humans; Language; Motor Activity/physiology; Schizophrenia/*physiopathology |
|
| |
Abstract |
Anomalies in the laterality of numerous neurocognitive dimensions associated with schizophrenia have been documented, but their role in the etiology and early development of the disorder remain unclear. In the study of normative neurobehavioral organization, animal models have shed much light on the mechanisms underlying and the factors affecting adult patterns of both functional and structural asymmetry. Nonhuman species have more recently been used to investigate the environmental, genetic, and neuroendocrine factors associated with developmental language disorders in humans. We propose that the animal models used to study the basis of lateralization in normative development and language disorders such as dyslexia could be modified to investigate lateralized phenomena in schizophrenia. |
|
| |
Address |
Dept. of Human Communication Sciences, University of Sheffield, United Kingdom |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language  |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0586-7614 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:10098913 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
2827 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Anderson, T.M.; McIlwraith, C.W.; Douay, P. |
|
| |
Title |
The role of conformation in musculoskeletal problems in the racing Thoroughbred |
Type |
Journal Article |
| |
Year |
2004 |
Publication |
Equine Veterinary Journal |
Abbreviated Journal |
Equine Vet J |
|
| |
Volume |
36 |
Issue |
7 |
Pages |
571-575 |
|
| |
Keywords |
Animals; Carpus, Animal/anatomy & histology/physiology; Horse Diseases/etiology/*pathology/surgery; Horses/*anatomy & histology/injuries/physiology; Likelihood Functions; Logistic Models; Muscle, Skeletal/*anatomy & histology/pathology; Musculoskeletal Diseases/pathology/surgery/*veterinary; Tarsus, Animal/anatomy & histology/physiology; Treatment Outcome |
|
| |
Abstract |
REASONS FOR PERFORMING STUDY: The relationship of conformation to future potential injury is a standard approach in practise but, at present, is largely based on subjective observations. OBJECTIVE: To measure conformation in 3-year-old Thoroughbreds and objectively test its relationship with the occurrence of musculoskeletal problems. METHODS: Conformation measurements were taken from photographs using specific reference points marked on the horses and processed on the computer. Clinical observations were recorded for each horse on a regular basis. Stepwise (forward) logistic regression analysis was performed to investigate the relationship between the binary response of the clinical outcomes probability and the conformation variables by the method of maximum likelihood. RESULTS: Clinical outcomes significantly (P<0.05) associated with conformational variables included effusion of the front fetlock, effusion of the right carpus, effusion of the carpus, effusion of the hind fetlock, fracture of the left or right carpus, right front fetlock problem and hind fetlock problem. CONCLUSIONS: Offset knees (offset ratio) contributed to fetlock problems. Long pasterns increased the odds of a fracture in the front limb. An increase in the carpal angle as viewed from the front (carpal valgus) may serve as a protective mechanism, as the odds for a carpal fracture and carpal effusion decreased with an increase in the carpal angle. POTENTIAL RELEVANCE: This study demonstrates relationships between conformation and musculoskeletal disease in the racehorse. The information may be useful in selection and management of the racing Thoroughbred. |
|
| |
Address |
Colorado State University, Equine Science and Equine Orthopaedic Research Programs, Fort Collins, Colorado 80523, USA |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0425-1644 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:15581320 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
3697 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Gerber, V.; Robinson, N.E.; Luethi, S.; Marti, E.; Wampfler, B.; Straub, R. |
|
| |
Title |
Airway inflammation and mucus in two age groups of asymptomatic well-performing sport horses |
Type |
Journal Article |
| |
Year |
2003 |
Publication |
Equine Veterinary Journal |
Abbreviated Journal |
Equine Vet J |
|
| |
Volume |
35 |
Issue |
5 |
Pages |
491-495 |
|
| |
Keywords |
Age Factors; Animals; Bronchoalveolar Lavage Fluid/*cytology; Female; Flow Cytometry/veterinary; Horse Diseases/*physiopathology; Horses; Housing, Animal; Inflammation/veterinary; Leukocyte Count/veterinary; Male; Mucus/*secretion; Physical Conditioning, Animal; Respiratory Function Tests/veterinary; Respiratory Tract Diseases/physiopathology/*veterinary; Sports |
|
| |
Abstract |
REASONS FOR PERFORMING STUDY: Horses housed in conventional stable environments are exposed to high dust loads. Long-term exposure to inhaled dust may lead to subclinical airway disease. HYPOTHESES: Airway inflammation and mucus accumulation are 1) common in asymptomatic well-performing sport horses, 2) increased in older compared to younger individuals and 3) correlated. METHODS: Mucus quantity and quality (endoscopic scoring) and BALF differential cytology were assessed in 13 younger horses (mean age 5 years) and 13 older horses (mean age 15 years), which had no historical or clinical evidence of lower airway disease, were performing well and were housed permanently in a conventional stable environment. RESULTS: 1) Airway inflammation and/or mucus accumulation were very common. All sport horses showed evidence of subclinical inflammatory airway disease (IAD). 2) Older horses, having been exposed for 10 more years to a conventional stable environment, did not show increased subclinical airway inflammation or mucus accumulation. The only differences between the age groups were increased BALF total and lymphocyte cell counts in the younger horses. 3) Mucus quantity and quality scores were not significantly correlated with each other or with BALF neutrophil percentages and absolute numbers. CONCLUSIONS: Although clinically healthy and performing well, all of the examined horses housed in a conventional stable environment showed evidence of IAD. The degree of IAD was not increased in older horses that had not developed clinical signs. POTENTIAL RELEVANCE: The effect of subclinical degrees of IAD on performance in dressage and show jumping should be investigated further to better understand the clinical significance of IAD in sport horses. |
|
| |
Address |
Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, USA |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0425-1644 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:12875328 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
3721 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Herholz, C.; Straub, R.; Braendlin, C.; Imhof, A.; Luthi, S.; Busato, A. |
|
| |
Title |
Measurement of tidal breathing flow-volume loop indices in horses used for different sporting purposes with and without recurrent airway obstruction |
Type |
Journal Article |
| |
Year |
2003 |
Publication |
The Veterinary Record |
Abbreviated Journal |
Vet. Rec. |
|
| |
Volume |
152 |
Issue |
10 |
Pages |
288-292 |
|
| |
Keywords |
Airway Obstruction/*physiopathology; Animals; Horses/*physiology; Physical Conditioning, Animal/*physiology; *Respiration; Respiratory Function Tests/*veterinary; Sports; Tidal Volume/physiology |
|
| |
Abstract |
Tidal breathing flow-volume loop (TBFVL) indices in healthy horses and in horses suffering from mild and moderate to severe recurrent airway obstruction (RAO) were measured. In addition, the ability of these indices to differentiate healthy controls from horses with mild RAO by separating the horses according to their usage was investigated. The horses were assigned to three sporting categories: 1 Leisure horses; 2 Horses competing at events with a duration of more than five minutes (eventing, coaching and endurance); and 3 Horses competing at events with a duration of less than five minutes (dressage and show jumping). Flow-volume curves were recorded with an ultrasonic spirometer and TBFVL indices were calculated with specially dedicated software. The sporting usage of the horses had a significant effect on the differentiating ability of TBFVL indices in diagnosing different degrees of RAO. The index TIF50 differentiated control horses from horses with minor RAO in all sporting categories. |
|
| |
Address |
Department of Equine Internal Medicine, Faculty of Veterinary Medicine, University of Berne, Langgasstrasse 124, CH-3012 Berne, Switzerland |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0042-4900 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:12650471 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
3725 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Touma, C.; Palme, R.; Sachser, N. |
|
| |
Title |
Analyzing corticosterone metabolites in fecal samples of mice: a noninvasive technique to monitor stress hormones |
Type |
Journal Article |
| |
Year |
2004 |
Publication |
Hormones and Behavior |
Abbreviated Journal |
Horm Behav |
|
| |
Volume |
45 |
Issue |
1 |
Pages |
10-22 |
|
| |
Keywords |
Adrenal Cortex/drug effects; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone/pharmacology; Analysis of Variance; Animals; Circadian Rhythm; Corticosterone/*analysis/metabolism; Dexamethasone/pharmacology; Feces/*chemistry; Female; Immunoenzyme Techniques/*methods; Male; Mice; Mice, Inbred C57BL; Models, Animal; Reproducibility of Results; Stress, Psychological/*metabolism |
|
| |
Abstract |
In small animals like mice, the monitoring of endocrine functions over time is constrained seriously by the adverse effects of blood sampling. Therefore, noninvasive techniques to monitor, for example, stress hormones in these animals are highly demanded in laboratory as well as in field research. The aim of our study was to evaluate the biological relevance of a recently developed technique to monitor stress hormone metabolites in fecal samples of laboratory mice. In total, six experiments were performed using six male and six female mice each. Two adrenocorticotropic hormone (ACTH) challenge tests, two dexamethasone (Dex) suppression tests and two control experiments [investigating effects of the injection procedure itself and the diurnal variation (DV) of glucocorticoids (GCs), respectively] were conducted. The experiments clearly demonstrated that pharmacological stimulation and suppression of adrenocortical activity was reflected accurately by means of corticosterone metabolite (CM) measurements in the feces of males and females. Furthermore, the technique proved sensitive enough to detect dosage-dependent effects of the ACTH/Dex treatment and facilitated to reveal profound effects of the injection procedure itself. Even the naturally occurring DV of GCs could be monitored reliably. Thus, our results confirm that measurement of fecal CM with the recently established 5alpha-pregnane-3beta,11beta,21-triol-20-one enzyme immunoassay is a very powerful tool to monitor adrenocortical activity in laboratory mice. Since mice represent the vast majority of all rodents used for research worldwide and the number of transgenic and knockout mice utilized as animal models is still increasing, this noninvasive technique can open new perspectives in biomedical and behavioral science. |
|
| |
Address |
Department of Behavioural Biology, University of Muenster, D-48149 Muenster, Germany. touma@uni-muenster.de |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0018-506X |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:14733887 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
4084 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Ganswindt, A.; Palme, R.; Heistermann, M.; Borragan, S.; Hodges, J.K. |
|
| |
Title |
Non-invasive assessment of adrenocortical function in the male African elephant (Loxodonta africana) and its relation to musth |
Type |
Journal Article |
| |
Year |
2003 |
Publication |
General and Comparative Endocrinology |
Abbreviated Journal |
Gen Comp Endocrinol |
|
| |
Volume |
134 |
Issue |
2 |
Pages |
156-166 |
|
| |
Keywords |
Adrenal Cortex/*metabolism/secretion; Adrenal Cortex Function Tests/methods/*veterinary; Adrenocorticotropic Hormone/physiology; Animals; Carbon Isotopes/diagnostic use; Chromatography, High Pressure Liquid/veterinary; Elephants/*metabolism/urine; Feces/*chemistry; Glucocorticoids/analysis/urine; Hydrocortisone/*analysis/diagnostic use/urine; Immunoenzyme Techniques/methods/veterinary; Male; Reproduction/physiology; Sexual Behavior, Animal/physiology; Stress, Psychological/diagnosis/*physiopathology; Testosterone/*analysis/diagnostic use/urine |
|
| |
Abstract |
Adult male elephants periodically show the phenomenon of musth, a condition associated with increased aggressiveness, restlessness, significant weight reduction and markedly elevated androgen levels. It has been suggested that musth-related behaviours are costly and that therefore musth may represent a form of physiological stress. In order to provide data on this largely unanswered question, the first aim of this study was to evaluate different assays for non-invasive assessment of adrenocortical function in the male African elephant by (i) characterizing the metabolism and excretion of [3H]cortisol (3H-C) and [14C]testosterone (14C-T) and (ii) using this information to evaluate the specificity of four antibodies for determination of excreted cortisol metabolites, particularly with respect to possible cross-reactions with androgen metabolites, and to assess their biological validity using an ACTH challenge test. Based on the methodology established, the second objective was to provide data on fecal cortisol metabolite concentrations in bulls during the musth and non-musth condition. 3H-C (1 mCi) and 14C-T (100 microCi) were injected simultaneously into a 16 year old male and all urine and feces collected for 30 and 86 h, respectively. The majority (82%) of cortisol metabolites was excreted into the urine, whereas testosterone metabolites were mainly (57%) excreted into the feces. Almost all radioactive metabolites recovered from urine were conjugated (86% 3H-C and 97% 14C-T). In contrast, 86% and >99% of the 3H-C and 14C-T metabolites recovered from feces consisted of unconjugated forms. HPLC separations indicated the presence of various metabolites of cortisol in both urine and feces, with cortisol being abundant in hydrolysed urine, but virtually absent in feces. Although all antibodies measured substantial amounts of immunoreactivity after HPLC separation of peak radioactive samples and detected an increase in glucocorticoid output following the ACTH challenge, only two (in feces against 3alpha,11-oxo-cortisol metabolites, measured by an 11-oxo-etiocholanolone-EIA and in urine against cortisol, measured by a cortisol-EIA) did not show substantial cross-reactivity with excreted 14C-T metabolites and could provide an acceptable degree of specificity for reliable assessment of glucocorticoid output from urine and feces. Based on these findings, concentrations of immunoreactive 3alpha,11-oxo-cortisol metabolites were determined in weekly fecal samples collected from four adult bulls over periods of 11-20 months to examine whether musth is associated with increased adrenal activity. Results showed that in each male levels of these cortisol metabolites were not elevated during periods of musth, suggesting that in the African elephant musth is generally not associated with marked elevations in glucocorticoid output. Given the complex nature of musth and the variety of factors that are likely to influence its manifestation, it is clear, however, that further studies, particularly on free-ranging animals, are needed before a possible relationship between musth and adrenal function can be resolved. This study also clearly illustrates the potential problems associated with cross-reacting metabolites of gonadal steroids in EIAs measuring glucocorticoid metabolites. This has to be taken into account when selecting assays and interpreting results of glucocorticoid metabolite analysis, not only for studies in the elephant but also in other species. |
|
| |
Address |
German Primate Centre, Department of Reproductive Biology, Kellnerweg 4, 37077 Gottingen, Germany. ganswindt@www.dpz.gdwg.de |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0016-6480 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:14511986 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
4085 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
van der Kolk, J.H.; Nachreiner, R.F.; Schott, H.C.; Refsal, K.R.; Zanella, A.J. |
|
| |
Title |
Salivary and plasma concentration of cortisol in normal horses and horses with Cushing's disease |
Type |
Journal Article |
| |
Year |
2001 |
Publication |
Equine Veterinary Journal |
Abbreviated Journal |
Equine Vet J |
|
| |
Volume |
33 |
Issue |
2 |
Pages |
211-213 |
|
| |
Keywords |
Adrenal Cortex Function Tests/standards/veterinary; Animals; Cushing Syndrome/diagnosis/metabolism/*veterinary; Female; Horse Diseases/blood/*diagnosis/metabolism; Horses/blood/*metabolism; Hydrocortisone/blood/*metabolism; Male; Predictive Value of Tests; Reference Values; Saliva/*metabolism |
|
| |
Abstract |
|
|
| |
Address |
Department of Large Animal Medicine and Nutrition, Veterinary Faculty, Utrecht University, The Netherlands |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0425-1644 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:11266074 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
4281 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Rogers, L.J. |
|
| |
Title |
Evolution of hemispheric specialization: advantages and disadvantages |
Type |
Journal Article |
| |
Year |
2000 |
Publication |
Brain and Language |
Abbreviated Journal |
Brain Lang |
|
| |
Volume |
73 |
Issue |
2 |
Pages |
236-253 |
|
| |
Keywords |
Aggression/psychology; Animals; Behavior, Animal/physiology; Brain/*physiology; Chickens/physiology; *Evolution; Feeding Behavior/physiology; Functional Laterality/*physiology; Visual Fields/physiology; Visual Perception/physiology |
|
| |
Abstract |
Lateralization of the brain appeared early in evolution and many of its features appear to have been retained, possibly even in humans. We now have a considerable amount of information on the different forms of lateralization in a number of species, and the commonalities of these are discussed, but there has been relatively little investigation of the advantages of being lateralized. This article reports new findings on the differences between lateralized and nonlateralized chicks. The lateralized chicks were exposed to light for 24 h on day 19 of incubation, a treatment known to lead to lateralization of a number of visually guided responses, and the nonlateralized chicks were incubated in the dark. When they were feeding, the lateralized chicks were found to detect a stimulus resembling a raptor with shorter latency than nonlateralized chicks. This difference was not a nonspecific effect caused by the light-exposed chicks being more distressed by the stimulus. Instead, it appears to be a genuine advantage conferred by having a lateralized brain. It is suggested that having a lateralized brain allows dual attention to the tasks of feeding (right eye and left hemisphere) and vigilance for predators (left eye and right hemisphere). Nonlateralized chicks appear to perform these dual tasks less efficiently than lateralized ones. Reference is made to other species in discussing these results. |
|
| |
Address |
Division of Zoology, University of New England, Armidale, New South Wales, Australia. lrogers@metz.une.edu.au |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0093-934X |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:10856176 |
Approved |
no |
|
| |
Call Number |
Equine Behaviour @ team @ |
Serial |
4621 |
|
| Permanent link to this record |
