| Records |
| Author |
Cheung, C.; Akiyama, T.E.; Ward, J.M.; Nicol, C.J.; Feigenbaum, L.; Vinson, C.; Gonzalez, F.J. |
| Title |
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha |
Type |
Journal Article |
| Year |
2004 |
Publication |
Cancer research |
Abbreviated Journal |
Cancer Res |
| Volume |
64 |
Issue |
11 |
Pages |
3849-3854 |
| Keywords |
Animals; Anticholesteremic Agents/pharmacology; Carcinogens/pharmacology; Cell Division; DNA Replication/drug effects; Fatty Acids/metabolism; Hepatocytes/cytology/drug effects/metabolism/*physiology; Humans; Mice; Mice, Transgenic; Oxidation-Reduction; Peroxisome Proliferators/pharmacology; Pyrimidines/pharmacology; Receptors, Cytoplasmic and Nuclear/genetics/*physiology; Species Specificity; Transcription Factors/genetics/*physiology |
| Abstract |
Lipid-lowering fibrate drugs function as agonists for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). Sustained activation of PPARalpha leads to the development of liver tumors in rats and mice. However, humans appear to be resistant to the induction of peroxisome proliferation and the development of liver cancer by fibrate drugs. The molecular basis of this species difference is not known. To examine the mechanism determining species differences in peroxisome proliferator response between mice and humans, a PPARalpha-humanized mouse line was generated in which the human PPARalpha was expressed in liver under control of the tetracycline responsive regulatory system. The PPARalpha-humanized and wild-type mice responded to treatment with the potent PPARalpha ligand Wy-14643 as revealed by induction of genes encoding peroxisomal and mitochondrial fatty acid metabolizing enzymes and resultant decrease of serum triglycerides. However, surprisingly, only the wild-type mice and not the PPARalpha-humanized mice exhibited hepatocellular proliferation as revealed by elevation of cell cycle control genes, increased incorporation of 5-bromo-2'-deoxyuridine into hepatocyte nuclei, and hepatomegaly. These studies establish that following ligand activation, the PPARalpha-mediated pathways controlling lipid metabolism are independent from those controlling the cell proliferation pathways. These findings also suggest that structural differences between human and mouse PPARalpha are responsible for the differential susceptibility to the development of hepatocarcinomas observed after treatment with fibrates. The PPARalpha-humanized mice should serve as models for use in drug development and human risk assessment and to determine the mechanism of hepatocarcinogenesis of peroxisome proliferators. |
| Address |
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0008-5472 |
ISBN |
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Conference |
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| Notes |
PMID:15172993 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
74 |
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| Author |
Hare, B.; Brown, M.; Williamson, C.; Tomasello, M. |
| Title |
The domestication of social cognition in dogs |
Type |
Journal Article |
| Year |
2002 |
Publication |
Science (New York, N.Y.) |
Abbreviated Journal |
Science |
| Volume |
298 |
Issue |
5598 |
Pages |
1634-1636 |
| Keywords |
Animals; *Animals, Domestic; *Behavior, Animal; *Cognition; *Cues; *Dogs; Food; Humans; Memory; Pan troglodytes; *Social Behavior; Species Specificity; Vision; Wolves |
| Abstract |
Dogs are more skillful than great apes at a number of tasks in which they must read human communicative signals indicating the location of hidden food. In this study, we found that wolves who were raised by humans do not show these same skills, whereas domestic dog puppies only a few weeks old, even those that have had little human contact, do show these skills. These findings suggest that during the process of domestication, dogs have been selected for a set of social-cognitive abilities that enable them to communicate with humans in unique ways. |
| Address |
Department of Anthropology, Harvard University, Cambridge, MA 02138, USA. bhare@fas.harvard.edu |
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English |
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Series Issue |
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Edition |
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| ISSN |
1095-9203 |
ISBN |
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Conference |
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| Notes |
PMID:12446914 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
595 |
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| Author |
Hall, C.A.; Cassaday, H.J.; Derrington, A.M. |
| Title |
The effect of stimulus height on visual discrimination in horses |
Type |
Journal Article |
| Year |
2003 |
Publication |
Journal of Animal Science |
Abbreviated Journal |
J. Anim Sci. |
| Volume |
81 |
Issue |
7 |
Pages |
1715-1720 |
| Keywords |
Animals; *Discrimination Learning/physiology; Female; Horses/physiology/*psychology; Male; Orientation; *Photic Stimulation; Vision/*physiology |
| Abstract |
This study investigated the effect of stimulus height on the ability of horses to learn a simple visual discrimination task. Eight horses were trained to perform a two-choice, black/white discrimination with stimuli presented at one of two heights: ground level or at a height of 70 cm from the ground. The height at which the stimuli were presented was alternated from one session to the next. All trials within a single session were presented at the same height. The criterion for learning was four consecutive sessions of 70% correct responses. Performance was found to be better when stimuli were presented at ground level with respect to the number of trials taken to reach the criterion (P < 0.05), percentage of correct first choices (P < 0.01), and repeated errors made (P < 0.01). Thus, training horses to carry out tasks of visual discrimination could be enhanced by placing the stimuli on the ground. In addition, the results of the present study suggest that the visual appearance of ground surfaces is an important factor in both horse management and training. |
| Address |
School of Land-based Studies, Nottingham Trent University, Brackenhurst College Campus, Southwell, Nottinghamshire, England NG25 0QF. carol.hall@ntu.ac.uk |
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English |
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| ISSN |
0021-8812 |
ISBN |
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Conference |
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| Notes |
PMID:12854807 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
835 |
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| Author |
Harman, A.M.; Moore, S.; Hoskins, R.; Keller, P. |
| Title |
Horse vision and an explanation for the visual behaviour originally explained by the 'ramp retina' |
Type |
Journal Article |
| Year |
1999 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
| Volume |
31 |
Issue |
5 |
Pages |
384-390 |
| Keywords |
Animals; Behavior, Animal; Cell Count; Eye/*anatomy & histology; Ganglia, Sensory/cytology; Horses/*physiology; Refractive Errors/veterinary; Retina/cytology/*physiology; Vision/*physiology; Visual Acuity; Visual Fields |
| Abstract |
Here we provide confirmation that the 'ramp retina' of the horse, once thought to result in head rotating visual behaviour, does not exist. We found a 9% variation in axial length of the eye between the streak region and the dorsal periphery. However, the difference was in the opposite direction to that proposed for the 'ramp retina'. Furthermore, acuity in the narrow, intense visual streak in the inferior retina is 16.5 cycles per degree compared with 2.7 cycles per degree in the periphery. Therefore, it is improbable that the horse rotates its head to focus onto the peripheral retina. Rather, the horse rotates the nose up high to observe distant objects because binocular overlap is oriented down the nose, with a blind area directly in front of the forehead. |
| Address |
Department of Psychology, University of Western Australia, Nedlands, Australia |
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English |
Summary Language |
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Series Title |
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Series Issue |
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Edition |
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| ISSN |
0425-1644 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:10505953 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
836 |
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| Author |
van Niekerk, H.P. |
| Title |
Ethological studies within the man-horse relationship |
Type |
Journal Article |
| Year |
1980 |
Publication |
Journal of the South African Veterinary Association |
Abbreviated Journal |
J S Afr Vet Assoc |
| Volume |
51 |
Issue |
4 |
Pages |
237-238 |
| Keywords |
Animals; Behavior, Animal; Hearing; Horses/*physiology; Humans; Smell; Taste; Touch; Vision |
| Abstract |
Certain aspects of ethology and the horse's senses are discussed to bring about a better understanding between man and horse. Furthermore the behaviour of horses with respect to housing, feeding, breeding, veterinary treatment and work are considered. |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1019-9128 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:7241494 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
1960 |
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| Author |
Regolin, L.; Marconato, F.; Vallortigara, G. |
| Title |
Hemispheric differences in the recognition of partly occluded objects by newly hatched domestic chicks (Gallus gallus) |
Type |
Journal Article |
| Year |
2004 |
Publication |
Animal Cognition |
Abbreviated Journal |
Anim. Cogn. |
| Volume |
7 |
Issue |
3 |
Pages |
162-170 |
| Keywords |
Animals; Discrimination Learning/physiology; Dominance, Cerebral/*physiology; Female; Form Perception/*physiology; Imprinting (Psychology)/*physiology; Pattern Recognition, Visual/*physiology; Photic Stimulation; Random Allocation; Vision, Monocular/*physiology |
| Abstract |
Domestic chicks are capable of perceiving as a whole objects partly concealed by occluders (“amodal completion”). In previous studies chicks were imprinted on a certain configuration and at test they were required to choose between two alternative versions of it. Using the same paradigm we now investigated the presence of hemispheric differences in amodal completion by testing newborn chicks with one eye temporarily patched. Separate groups of newly hatched chicks were imprinted binocularly: (1) on a square partly occluded by a superimposed bar, (2) on a whole or (3) on an amputated version of the square. At test, in monocular conditions, each chick was presented with a free choice between a complete and an amputated square. In the crucial condition 1, chicks tested with only their left eye in use chose the complete square (like binocular chicks would do); right-eyed chicks, in contrast, tended to choose the amputated square. Similar results were obtained in another group of chicks imprinted binocularly onto a cross (either occluded or amputated in its central part) and required to choose between a complete or an amputated cross. Left-eyed and binocular chicks chose the complete cross, whereas right-eyed chicks did not choose the amputated cross significantly more often. These findings suggest that neural structures fed by the left eye (mainly located in the right hemisphere) are, in the chick, more inclined to a “global” analysis of visual scenes, whereas those fed by the right eye seem to be more inclined to a “featural” analysis of visual scenes. |
| Address |
Department of General Psychology, University of Padova, Via Venezia 8, 35131, Padova, Italy. lucia.regolin@unipd.it |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1435-9448 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:15241654 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2519 |
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| Author |
Timney, B.; Keil, K. |
| Title |
Local and global stereopsis in the horse |
Type |
Journal Article |
| Year |
1999 |
Publication |
Vision Research |
Abbreviated Journal |
Vision Res |
| Volume |
39 |
Issue |
10 |
Pages |
1861-1867 |
| Keywords |
Animals; Depth Perception/*physiology; Female; Horses/*physiology; Pattern Recognition, Visual/physiology; Psychophysics; Sensory Thresholds/physiology; Vision, Binocular/physiology; Vision, Monocular/physiology |
| Abstract |
Although horses have laterally-placed eyes, there is substantial binocular overlap, allowing for the possibility that these animals have stereopsis. In the first experiment of the present study we measured local stereopsis by obtaining monocular and binocular depth thresholds for renal depth stimuli. On all measures, the horses' binocular performance was superior to their monocular. When depth thresholds were obtained, binocular thresholds were several times superior to those obtained monocularly, suggesting that the animals could use stereoscopic information when it was available. The binocular thresholds averaged about 15 min arc. In the second experiment we obtained evidence for the presence of global stereopsis by testing the animals' ability to discriminate between random-dot stereograms with and without consistent disparity information. When presented with such stimuli they showed a strong preference for the cyclopean equivalent of the positive stimulus with the real depth. These results provide the first behavioral demonstration of a full range of stereoscopic skills in a lateral-eyed mammal. |
| Address |
Department of Psychology, Faculty of Social Science, University of Western Ontario, London, Canada. timney@julian.uwo.ca |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0042-6989 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:10343877 |
Approved |
yes |
| Call Number |
Equine Behaviour @ team @ |
Serial |
3580 |
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| Author |
Wolfe, J.M. |
| Title |
Hidden visual processes |
Type |
Journal Article |
| Year |
1983 |
Publication |
Scientific American |
Abbreviated Journal |
Sci Am |
| Volume |
248 |
Issue |
2 |
Pages |
94-103 |
| Keywords |
Color Perception/*physiology; Humans; Motion Perception/physiology; Ocular Physiology; Vision; Visual Perception/*physiology |
| Abstract |
Isoluminant stimulus is an image whose edges are defined only by a change in color, not by change in brightness. The stimulus here is imperfect: the blue parts and the green parts of the image are only as nearly equal in brightness as they can be on the printed page. Moreover, the change in brightness beyond the edge of the page is apparent, and so is the fact that the reader is holding the magazine at reading distance. When such cues are removed under laboratory conditions, subjects faced with an isoluminant stimulus prove unable to bring its edges into focus. This deficiency contributes to making a familiar face hard to recognize. The experiment indicates that the brain process underlying visual accommodation (the focusing of the eyes) cannot “see” color; it is a hidden process distinct from the processes that lead to perception. The image shows Groucho Marx as he appeared in the motion picture Horse Feathers. |
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English |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0036-8733 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:6836258 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4066 |
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| Author |
Hirata, S. |
| Title |
A note on the responses of chimpanzees (Pan troglodytes) to live self-images on television monitors |
Type |
Journal Article |
| Year |
2007 |
Publication |
Behavioural Processes |
Abbreviated Journal |
Behav. Process. |
| Volume |
75 |
Issue |
1 |
Pages |
85-90 |
| Keywords |
Animals; *Discrimination Learning; Female; Male; Pan troglodytes/*psychology; *Self Concept; Self Psychology; Social Behavior; Television |
| Abstract |
The majority of studies on self-recognition in animals have been conducted using a mirror as the test device; little is known, however, about the responses of non-human primates toward their own images in media other than mirrors. This study provides preliminary data on the reactions of 10 chimpanzees to live self-images projected on two television monitors, each connected to a different video camera. Chimpanzees could see live images of their own faces, which were approximately life-sized, on one monitor. On the other monitor, they could see live images of their whole body, which were approximately one-fifth life-size, viewed diagonally from behind. In addition, several objects were introduced into the test situation. Out of 10 chimpanzees tested, 2 individuals performed self-exploratory behaviors while watching their own images on the monitors. One of these two chimpanzees successively picked up two of the provided objects in front of a monitor, and watched the images of these objects on the monitor. The results indicate that these chimpanzees were able to immediately recognize live images of themselves or objects on the monitors, even though several features of these images differed from those of their previous experience with mirrors. |
| Address |
Great Ape Research Institute, Hayashibara Biochemical Laboratories Inc., Okayama, Japan. hirata@gari.be.to |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0376-6357 |
ISBN |
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Conference |
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| Notes |
PMID:17324534 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4145 |
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| Author |
Loveland, K.A. |
| Title |
Self-recognition in the bottlenose dolphin: ecological considerations |
Type |
Journal Article |
| Year |
1995 |
Publication |
Consciousness and Cognition |
Abbreviated Journal |
Conscious Cogn |
| Volume |
4 |
Issue |
2 |
Pages |
254-257 |
| Keywords |
Animals; Attention; *Awareness; Body Image; Dolphins/*psychology; Exploratory Behavior; Female; Male; *Self Concept; *Social Environment; Species Specificity; Television; *Visual Perception |
| Abstract |
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| Address |
Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston 77025, USA |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1053-8100 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:8521267 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4161 |
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