| Records |
| Author |
Maury, M.; Murphy, K.; Kumar, S.; Mauerer, A.; Lee, G. |
| Title |
Spray-drying of proteins: effects of sorbitol and trehalose on aggregation and FT-IR amide I spectrum of an immunoglobulin G |
Type |
Journal Article |
| Year |
2005 |
Publication |
European Journal of Pharmaceutics and Biopharmaceutics |
Abbreviated Journal |
Eur. J. Pharm. Biopharm. |
| Volume |
59 |
Issue |
2 |
Pages |
251-261 |
Keywords  |
Immunoglobulin; Spray-drying; Stabilization; Sorbitol; Trehalose; Water replacement |
| Abstract |
An immunoglobulin G (IgG) was spray-dried on a Büchi 190 laboratory spray-dryer at inlet and outlet air temperatures of 130 and 190°C, respectively. The IgG solution contains initially 115mg/ml IgG plus 50mg/ml sorbitol. After dialysis, at least 80% of low molecular weight component was removed. After spray-drying the dialyzed IgG and immediate redissolution of the powder, an increase in aggregates from 1 to 17% occurred. A major shift towards increase β-sheet structure was detected in the spray-dried solid, which, however, reverted to native structure on redissolution of the powder. A correlation between aggregation determined by size exclusion chromatography and alterations in secondary structure determined by Fourier transformation infra-red spectroscopy could not therefore be established. On spray-drying a non-dialyzed, sorbitol-containing IgG only some 0.7% aggregates were formed. The sorbitol is therefore evidently able to stabilize partially the IgG during the process of spray-drying. Addition of trehalose to the liquid feed produced quantitatively the same stabilizing action on the IgG during spray-drying as did the sorbitol. This finding again points towards a water replacement stabilization mechanism. The IgG spray-dried powder prepared from the dialyzed liquid feed showed continued substantial aggregation on dry storage at 25°C. This was substantially less in the non-dialyzed, sorbitol-containing spray-dried powder. Addition of trehalose to both dialyzed and non-dialyzed system produced substantial improvement in storage stability and reduction in aggregate formation in storage. The quantitative stabilizing effect of the trehalose was only slightly higher than that of the sorbitol. Taken together, these results indicate that both the sorbitol and trehalose stabilize the IgG primarily by a water replacement mechanism rather than by glassy immobilization. The relevance of this work is its questioning of the importance of the usually considered dominance of glassy stabilization of protein in dried systems of high glass transition temperature, such as trehalose. The low glass transition temperature sorbitol produces almost equal process and storage stability in this case. |
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0939-6411 |
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Equine Behaviour @ team @ |
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6515 |
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| Author |
Galef, B.G. |
| Title |
Imitation and local enhancement: Detrimental effects of consensus definitions on analyses of social learning in animals |
Type |
Journal Article |
| Year |
2013 |
Publication |
Behavioural Processes |
Abbreviated Journal |
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| Volume |
100 |
Issue |
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Pages |
123-130 |
| Keywords |
Imitation; Local enhancement; Emulation; Copying; Culture; Tradition |
| Abstract |
Development of a widely accepted vocabulary referring to various types of social learning has made important contributions to decades of progress in analyzing the role of socially acquired information in the development of behavioral repertoires. It is argued here that emergence of a consensus vocabulary, while facilitating both communication and research, has also unnecessarily restricted research on social learning. The article has two parts. In the first, I propose that Thorndike, 1898, Thorndike, 1911 definition of imitation as “learning to do an act from seeing it done” has unduly restricted studies of the behavioral processes involved in the propagation of behavior. In part 2, I consider the possibility that success in labeling social learning processes believed to be less cognitively demanding than imitation (e.g. local and stimulus enhancement, social facilitation, etc.) has been mistaken for understanding of those processes, although essentially nothing is known of their stimulus control, development, phylogeny or substrate either behavioral or physiological. |
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0376-6357 |
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no |
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Equine Behaviour @ team @ |
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6419 |
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| Author |
Alexander, F. |
| Title |
The effects of some humoral agents on the horse ileum |
Type |
Journal Article |
| Year |
1952 |
Publication |
British journal of pharmacology and chemotherapy |
Abbreviated Journal |
Br J Pharmacol Chemother |
| Volume |
7 |
Issue |
1 |
Pages |
25-32 |
| Keywords |
Ileum/*drug effects; *HORMONES/effects; *ILEUM/effect of drugs on |
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English |
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0366-0826 |
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| Notes |
PMID:14904899 |
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no |
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refbase @ user @ |
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126 |
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Waldern, N.M.; Wiestner, T.; Ramseier, L.C.; Amport, C.; Weishaupt, M.A. |
| Title |
Effects of shoeing on limb movement and ground reaction forces in Icelandic horses at walk, tölt and trot |
Type |
Journal Article |
| Year |
2013 |
Publication |
The Veterinary Journal |
Abbreviated Journal |
Vet. J. |
| Volume |
198, Supplement 1 |
Issue |
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Pages |
e103-e108 |
| Keywords |
Icelandic horse; Gait analysis; Ground reaction force; Kinematics; Shoeing; Tölt |
| Abstract |
Abstract Tölt is a symmetric four-beat gait with a speed range extending into that of trot and canter. Specific shoeing methods, such as unnaturally high and long hooves, are used to enforce individual gait predisposition. The aim of this study was to assess the consequences of this shoeing style on loading and movement of the limbs at walk, tölt and trot, and at different velocities. Simultaneous kinetic and kinematic gait analysis was carried out at walk (1.4 m/s) and at two tölting and trotting speeds (3.3 m/s and 3.9 m/s) on an instrumented treadmill. Thirteen sound Icelandic horses were first measured with high, long front hooves (SH) and, 1 week later, after trimming the hooves according to standard shoeing principles (SN). Comparing SH with SN, front hooves had 21 ± 5 mm longer dorsal hoof walls, and the shoeing material per hoof was 273 ± 50 g heavier. In all three gaits, gait quality, as it is currently judged, was improved with SH due to a lower stride rate, a longer stride length and a higher, but not wider, forelimb protraction arc, which were also positively associated with speed. Forelimb–hind limb balance remained unchanged, but limb impulses were higher. Apart from an increase of ⩽2.2% in the forelimbs at the faster speed of both tölt and trot, SH had little influence on vertical peak forces. |
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1090-0233 |
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Equine Behaviour @ team @ |
Serial |
5912 |
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| Author |
Zebisch, A.; May, A.; Reese, S.; Gehlen, H. |
| Title |
Effect of different head-neck positions on physical and psychological stress parameters in the ridden horse |
Type |
Journal Article |
| Year |
2013 |
Publication |
Journal of Animal Physiology and Animal Nutrition |
Abbreviated Journal |
J Anim Physiol Anim Nutr |
| Volume |
98 |
Issue |
5 |
Pages |
901-907 |
| Keywords |
hyperflexion; head-neck position; stress; training; animal welfare |
| Abstract |
Summary Different head?neck positions (HNPs) are used in equestrian sports and are regarded as desirable for training and competition by riders, judges and trainers. Even though some studies have been indicative of hyperflexion having negative effects on horses, this unnatural position is frequently used. In the present study, the influence of different HNPs on physical and psychological stress parameters in the ridden horse was investigated. Heart rate (HR), heart rate variability (HRV) and blood cortisol levels were measured in 18 horses. Low frequency (LF) and high frequency (HF) are power components in the frequency domain measurement of HRV which show the activity of the sympathetic and parasympathetic nervous system. Values were recorded at rest, while riding with a working HNP and while riding with hyperflexion of the horse's head, neck and poll. In addition, rideability and behaviour during the different investigation stages were evaluated by the rider and by an observer. Neither the HR nor the HRV showed a significant difference between working HNP (HR = 105 ± 22/min; LF/HF = 3.89 ± 5.68; LF = 37.28 ± 10.77%) and hyperflexion (HR = 110 ± 18; LF/HF = 1.94 ± 2.21; LF = 38.39 ± 13.01%). Blood cortisol levels revealed a significant increase comparing working HNP (158 ± 60 nm) and hyperflexion (176 ± 64 nm, p = 0.01). The evaluation of rider and observer resulted in clear changes of rideability and behavioural changes for the worse in all parameters collected between a working HNP and hyperflexion. In conclusion, changes of the cortisol blood level as a physical parameter led to the assumption that hyperflexion of head, neck and poll effects a stress reaction in the horse, and observation of the behaviour illustrates adverse effects on the well-being of horses during hyperflexion. |
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Wiley/Blackwell (10.1111) |
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| ISSN |
0931-2439 |
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| Notes |
doi: 10.1111/jpn.12155 |
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no |
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Equine Behaviour @ team @ |
Serial |
6427 |
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| Author |
Tibbetts, E.A. |
| Title |
Visual signals of individual identity in the wasp Polistes fuscatus |
Type |
Journal Article |
| Year |
2002 |
Publication |
Proceedings of the Royal Society B: Biological Sciences |
Abbreviated Journal |
Proc. Roy. Soc. Lond. B Biol. Sci. |
| Volume |
269 |
Issue |
1423 |
Pages |
1423-1428 |
| Keywords |
hymenoptera; individual-recognition; learning-insect |
| Abstract |
Individual recognition is an essential component of interactions in many social systems, but insects are often thought incapable of the sophistication necessary to recognize individuals. If this were true, it would impose limits on the societies that insects could form. For example, queens and workers of the paper wasp Polistes fuscatus form a linear dominance hierarchy that determines how food, work and reproduction are divided within the colony. Such a stable hierarchy would be facilitated if individuals of different ranks have some degree of recognition. P. fuscatus wasps have, to our knowledge, previously undocumented variability in their yellow facial and abdominal markings that are intriguing candidates for signals of individual identity. Here, I describe these highly variable markings and experimentally test whether P. fuscatus queens and workers use these markings to identify individual nest-mates visually. I demonstrate that individuals whose yellow markings are experimentally altered with paint receive more aggression than control wasps who are painted in a way that does not alter their markings. Further, aggression declines towards wasps with experimentally altered markings as these novel markings become familiar to their nestmates. This evidence for individual recognition in P. fuscatus indicates that interactions between insects may be even more complex than previously anticipated.
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no |
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Equine Behaviour @ team @ 929 |
Serial |
4732 |
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| Author |
Krueger, K.; Flauger, B.; Farmer, K.; Maros, K. |
| Title |
Horses (Equus caballus) use human local enhancement cues and adjust to human attention |
Type |
Journal Article |
| Year |
2011 |
Publication |
Animal Cognition |
Abbreviated Journal |
Anim. Cogn. |
| Volume |
14 |
Issue |
2 |
Pages |
187-201 |
| Keywords |
Human–horse interaction – Horse – Attention-reading – Position – Familiarity |
| Abstract |
This study evaluates the horse (Equus caballus) use of human local enhancement cues and reaction to human attention when making feeding decisions. The superior performance of dogs in observing human states of attention suggests this ability evolved with domestication. However, some species show an improved ability to read human cues through socialization and training. We observed 60 horses approach a bucket with feed in a three-way object-choice task when confronted with (a) an unfamiliar or (b) a familiar person in 4 different situations: (1) squatting behind the bucket, facing the horse (2) standing behind the bucket, facing the horse (3) standing behind the bucket in a back-turned position, gazing away from the horse and (4) standing a few meters from the bucket in a distant, back-turned position, again gazing away from the horse. Additionally, postures 1 and 2 were tested both with the person looking permanently at the horse and with the person alternating their gaze between the horse and the bucket. When the person remained behind the correct bucket, it was chosen significantly above chance. However, when the test person was turned and distant from the buckets, the horses’ performance deteriorated. In the turned person situations, the horses approached a familiar person and walked towards their focus of attention significantly more often than with an unfamiliar person. Additionally, in the squatting and standing person situations, some horses approached the person before approaching the correct bucket. This happened more with a familiar person. We therefore conclude that horses can use humans as a local enhancement cue independently of their body posture or gaze consistency when the persons remain close to the food source and that horses seem to orientate on the attention of familiar more than of unfamiliar persons. We suggest that socialization and training improve the ability of horses to read human cues. |
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Springer Berlin / Heidelberg |
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1435-9448 |
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no |
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Equine Behaviour @ team @ |
Serial |
5178 |
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Méary, D.; Li, Z.; Li, W.; Guo, K.; Pascalis, O. |
| Title |
Seeing two faces together: preference formation in humans and rhesus macaques |
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Journal Article |
| Year |
2014 |
Publication |
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Abbreviated Journal |
Animal Cognition |
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Issue |
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Pages |
1-13 |
| Keywords |
Humans; Rhesus macaques; Preferences; Faces; Eye-tracking |
| Abstract |
Humans, great apes and old world monkeys show selective attention to faces depending on conspecificity, familiarity, and social status supporting the view that primates share similar face processing mechanisms. Although many studies have been done on face scanning strategy in monkeys and humans, the mechanisms influencing viewing preference have received little attention. To determine how face categories influence viewing preference in humans and rhesus macaques (Macaca mulatta), we performed two eye-tracking experiments using a visual preference task whereby pairs of faces from different species were presented simultaneously. The results indicated that viewing time was significantly influenced by the pairing of the face categories. Humans showed a strong bias towards an own-race face in an Asian–Caucasian condition. Rhesus macaques directed more attention towards non-human primate faces when they were paired with human faces, regardless of the species. When rhesus faces were paired with faces from Barbary macaques (Macaca sylvanus) or chimpanzees (Pan troglodytes), the novel species’ faces attracted more attention. These results indicate that monkeys’ viewing preferences, as assessed by a visual preference task, are modulated by several factors, species and dominance being the most influential. |
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Springer Berlin Heidelberg |
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English |
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1435-9448 |
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no |
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Equine Behaviour @ team @ |
Serial |
5790 |
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| Author |
Pattison, P.; Wasserman, S. |
| Title |
Logit models and logistic regressions for social networks: II. Multivariate relations |
Type |
Journal Article |
| Year |
1999 |
Publication |
The British Journal of Mathematical and Statistical Psychology |
Abbreviated Journal |
Br J Math Stat Psychol |
| Volume |
52 ( Pt 2) |
Issue |
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Pages |
169-193 |
| Keywords |
Humans; Markov Chains; *Models, Statistical; Organization and Administration; *Social Support |
| Abstract |
The research described here builds on our previous work by generalizing the univariate models described there to models for multivariate relations. This family, labelled p*, generalizes the Markov random graphs of Frank and Strauss, which were further developed by them and others, building on Besag's ideas on estimation. These models were first used to model random variables embedded in lattices by Ising, and have been quite common in the study of spatial data. Here, they are applied to the statistical analysis of multigraphs, in general, and the analysis of multivariate social networks, in particular. In this paper, we show how to formulate models for multivariate social networks by considering a range of theoretical claims about social structure. We illustrate the models by developing structural models for several multivariate networks. |
| Address |
Department of Psychology, University of Melbourne, Parkville, Victoria, Australia. pattision@psych.unimelb.edu.au |
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English |
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0007-1102 |
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| Notes |
PMID:10613111 |
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no |
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Equine Behaviour @ team @ |
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5030 |
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| Author |
Birch, H.G. |
| Title |
The relation of previous experience to insightful problem-solving |
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Journal Article |
| Year |
1945 |
Publication |
Journal of Comparative Psychology |
Abbreviated Journal |
J Comp Psychol |
| Volume |
38 |
Issue |
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Pages |
367-383 |
| Keywords |
Humans; *Problem Solving; *Psychology, Comparative; *PSYCHOLOGY/comparative |
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English |
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Edition |
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0021-9940 |
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| Notes |
PMID:21010765 |
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no |
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Equine Behaviour @ team @ |
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6554 |
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