| Records |
| Author |
Cheung, C.; Akiyama, T.E.; Ward, J.M.; Nicol, C.J.; Feigenbaum, L.; Vinson, C.; Gonzalez, F.J. |
| Title |
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha |
Type |
Journal Article |
| Year |
2004 |
Publication |
Cancer research |
Abbreviated Journal |
Cancer Res |
| Volume |
64 |
Issue  |
11 |
Pages |
3849-3854 |
| Keywords |
Animals; Anticholesteremic Agents/pharmacology; Carcinogens/pharmacology; Cell Division; DNA Replication/drug effects; Fatty Acids/metabolism; Hepatocytes/cytology/drug effects/metabolism/*physiology; Humans; Mice; Mice, Transgenic; Oxidation-Reduction; Peroxisome Proliferators/pharmacology; Pyrimidines/pharmacology; Receptors, Cytoplasmic and Nuclear/genetics/*physiology; Species Specificity; Transcription Factors/genetics/*physiology |
| Abstract |
Lipid-lowering fibrate drugs function as agonists for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). Sustained activation of PPARalpha leads to the development of liver tumors in rats and mice. However, humans appear to be resistant to the induction of peroxisome proliferation and the development of liver cancer by fibrate drugs. The molecular basis of this species difference is not known. To examine the mechanism determining species differences in peroxisome proliferator response between mice and humans, a PPARalpha-humanized mouse line was generated in which the human PPARalpha was expressed in liver under control of the tetracycline responsive regulatory system. The PPARalpha-humanized and wild-type mice responded to treatment with the potent PPARalpha ligand Wy-14643 as revealed by induction of genes encoding peroxisomal and mitochondrial fatty acid metabolizing enzymes and resultant decrease of serum triglycerides. However, surprisingly, only the wild-type mice and not the PPARalpha-humanized mice exhibited hepatocellular proliferation as revealed by elevation of cell cycle control genes, increased incorporation of 5-bromo-2'-deoxyuridine into hepatocyte nuclei, and hepatomegaly. These studies establish that following ligand activation, the PPARalpha-mediated pathways controlling lipid metabolism are independent from those controlling the cell proliferation pathways. These findings also suggest that structural differences between human and mouse PPARalpha are responsible for the differential susceptibility to the development of hepatocarcinomas observed after treatment with fibrates. The PPARalpha-humanized mice should serve as models for use in drug development and human risk assessment and to determine the mechanism of hepatocarcinogenesis of peroxisome proliferators. |
| Address |
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0008-5472 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:15172993 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
74 |
| Permanent link to this record |
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| Author |
Alexander, F. |
| Title |
Multiple fistulation of the horse's large intestine |
Type |
Journal Article |
| Year |
1970 |
Publication |
The British veterinary journal |
Abbreviated Journal |
Br. Vet. J. |
| Volume |
126 |
Issue |
11 |
Pages |
604-606 |
| Keywords |
Animals; Cecum/physiology; Colon/physiology; Horses/*physiology; Intestinal Fistula; Intestine, Large/*physiology; *Intubation, Gastrointestinal; Methods |
| Abstract |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0007-1935 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:5492494 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
115 |
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| Author |
Markman, E.M.; Abelev, M. |
| Title |
Word learning in dogs? |
Type |
Journal Article |
| Year |
2004 |
Publication |
Trends in Cognitive Sciences |
Abbreviated Journal |
Trends. Cognit. Sci. |
| Volume |
8 |
Issue |
11 |
Pages |
479-81; discussion 481 |
| Keywords |
Animals; Association Learning; Dogs; *Learning; *Verbal Learning; *Vocabulary |
| Abstract |
In a recent paper, Kaminski, Call and Fischer report pioneering research on word-learning in a dog. In this commentary we suggest ways of distinguishing referential word use from mere association. We question whether the dog is reasoning by exclusion and, if so, compare three explanations – learned heuristics, default assumptions, and pragmatic reasoning – as they apply to children and might apply to dogs. Kaminski et al.'s work clearly raises important questions about the origins and basis of word learning and social cognition. |
| Address |
Department of Psychology, Stanford University, Bldg 420, Stanford, CA 94305-2130, USA |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1364-6613 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:15491899 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
274 |
| Permanent link to this record |
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| Author |
Cancedda, M. |
| Title |
[Social and behavioral organization of horses on the Giara (Sardinia): distribution and aggregation] |
Type |
Journal Article |
| Year |
1990 |
Publication |
Bollettino della Societa italiana di biologia sperimentale |
Abbreviated Journal |
Boll Soc Ital Biol Sper |
| Volume |
66 |
Issue |
11 |
Pages |
1089-1096 |
| Keywords |
Animals; *Animals, Wild/physiology/psychology; Environment; Female; *Horses/physiology/psychology; Italy; Male; Population Density; Sexual Behavior, Animal; *Social Behavior; Social Dominance; Water |
| Abstract |
In this paper some considerations on the environment of the 42 Kmq of the volcanic-basaltic Giara tableland are discussed. Conditioning by the environment and its effect on the distribution of a population of 712 horses is illustrated in view of their social and behavioural organization. |
| Address |
Istituto di Fisiologia Generale e Speciale, Universita di Sassari |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
Italian |
Summary Language |
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Original Title |
Introduzione all'organizzazione sociale e comportamentale dei cavallini sulla Giara (Sardegna): distribuzione ed aggregazione |
| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0037-8771 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:2095819 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
673 |
| Permanent link to this record |
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| Author |
McDonnell, S.M.; Freeman, D.A.; Cymbaluk, N.F.; Schott, H.C. 2nd; Hinchcliff, K.; Kyle, B. |
| Title |
Behavior of stabled horses provided continuous or intermittent access to drinking water |
Type |
Journal Article |
| Year |
1999 |
Publication |
American Journal of Veterinary Research |
Abbreviated Journal |
Am J Vet Res |
| Volume |
60 |
Issue |
11 |
Pages |
1451-1456 |
| Keywords |
Aggression; Animal Husbandry; Animals; Behavior, Animal/*physiology; Drinking Behavior; Feeding Behavior; Female; Horses/*physiology/*psychology; Housing, Animal; Pregnancy; Pregnancy, Animal/physiology/*psychology; Social Behavior; Videotape Recording; *Water Supply |
| Abstract |
OBJECTIVE: To compare quantitative measures and clinical assessments of behavior as an indication of psychologic well-being of stabled horses provided drinking water continuously or via 1 of 3 intermittent delivery systems. ANIMALS: 22 Quarter Horse (QH) or QH-crossbred mares and 17 Belgian or Belgian-crossbred mares (study 1) and 24 QH or QH-crossbred mares and 18 Belgian or Belgian-crossbred mares (study 2). PROCEDURE: Stabled horses were provided water continuously or via 1 of 3 intermittent water delivery systems in 2 study periods during a 2-year period. Continuous 24-hour videotaped samples were used to compare quantitative measures and clinical assessments of behavior among groups provided water by the various water delivery systems. RESULTS: All horses had clinically normal behavior. Significant differences in well being were not detected among groups provided water by the various delivery systems. CONCLUSIONS AND CLINICAL RELEVANCE: Various continuous and intermittent water delivery systems can provide adequately for the psychologic well-being of stabled horses. |
| Address |
New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square 19348, USA |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0002-9645 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:10566826 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
1928 |
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| Author |
Makarov, V.V.; Bakulov, I.A. |
| Title |
[Zoopathogenic arboviruses, their systematics and ecology] |
Type |
Journal Article |
| Year |
1975 |
Publication |
Veterinariia |
Abbreviated Journal |
Veterinariia |
| Volume |
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Issue |
11 |
Pages |
39-41 |
| Keywords |
Animals; Arboviruses/*classification/pathogenicity; Cattle; Deer; Ecology; Horses; Insect Vectors; Sheep; Swine; Turkeys; Viruses/*classification/pathogenicity |
| Abstract |
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| Address |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
Russian |
Summary Language |
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Original Title |
Zoopatogennye arbovirusy--sistematika i ekologiia |
| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0042-4846 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:814685 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2703 |
| Permanent link to this record |
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| Author |
Valova, G.P.; Mefod'ev, V.V. |
| Title |
[Specific features of an epidemic process in leptospiroses in northern conditions in Western Siberia] |
Type |
Journal Article |
| Year |
1972 |
Publication |
Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii |
Abbreviated Journal |
Zh Mikrobiol Epidemiol Immunobiol |
| Volume |
49 |
Issue |
11 |
Pages |
138-145 |
| Keywords |
Animals; Bird Diseases/epidemiology; Birds; Carnivora; Cattle; Cattle Diseases/epidemiology; Dog Diseases/epidemiology; Dogs; Ecology; Foxes; Horse Diseases/epidemiology; Horses; Humans; Insectivora; Leptospirosis/*epidemiology/veterinary; Mice; Rats; Reindeer; Rodent Diseases/epidemiology; Rodentia; Sheep; Sheep Diseases/epidemiology; Siberia |
| Abstract |
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| Address |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
Russian |
Summary Language |
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Original Title |
Nekotorye spetsificheskie cherty epidemicheskogo protsessa pri leptospirozakh v usloviiakh Severa v Zapadnoi Sibiri |
| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0372-9311 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:4645851 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2718 |
| Permanent link to this record |
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| Author |
Selby, L.A.; Marienfeld, C.J.; Pierce, J.O. |
| Title |
The effects of trace elements on human and animal health |
Type |
Journal Article |
| Year |
1970 |
Publication |
Journal of the American Veterinary Medical Association |
Abbreviated Journal |
J Am Vet Med Assoc |
| Volume |
157 |
Issue |
11 |
Pages |
1800-1808 |
| Keywords |
Anemia, Hypochromic/veterinary; Animal Nutrition Physiology; Animals; Artiodactyla/*physiology; Chemistry; Cobalt/analysis/metabolism; Copper/analysis/metabolism; Deficiency Diseases/veterinary; Dogs/*physiology; Ecology; Horses/*physiology; Humans; Iodine/analysis/metabolism; Iron/analysis/metabolism; Manganese/analysis/metabolism; Nutritional Requirements; Selenium/metabolism; Trace Elements/*metabolism; Zinc/analysis/metabolism |
| Abstract |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0003-1488 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:4922190 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2733 |
| Permanent link to this record |
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| Author |
Kirkwood, J.K. |
| Title |
Animal minds and animal welfare |
Type |
Journal Article |
| Year |
2000 |
Publication |
The Veterinary Record |
Abbreviated Journal |
Vet. Rec. |
| Volume |
146 |
Issue |
11 |
Pages |
327 |
| Keywords |
*Animal Welfare; Animals; Animals, Domestic/*psychology; *Cognition; Consciousness; Veterinary Medicine/standards |
| Abstract |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0042-4900 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:10766123 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2856 |
| Permanent link to this record |
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| Author |
Ordakowski-Burk, A.L.; Quinn, R.W.; Shellem, T.A.; Vough, L.R. |
| Title |
Voluntary intake and digestibility of reed canarygrass and timothy hay fed to horses |
Type |
Journal Article |
| Year |
2006 |
Publication |
Journal of Animal Science |
Abbreviated Journal |
J. Anim Sci. |
| Volume |
84 |
Issue |
11 |
Pages |
3104-3109 |
| Keywords |
Animal Feed/*analysis; Animal Nutrition Physiology; Animals; Diet/*veterinary; Digestion/*physiology; Feeding Behavior/*physiology; Horses/*physiology; Male; Poaceae/*metabolism |
| Abstract |
Thousands of hectares of timothy (Phleum pretense L.) grown in the Mid-Atlantic region are infected by cereal rust mite (Abacarus hysterix) that causes discoloration and curling of leaves, decreased nutritional quality, and substantial decreases in yield. A decline in production of timothy hay can lower income for hay producers and cause horse owners to search for alternative hays. Low alkaloid reed canarygrass (Phalaris arundinacea L.) hay has potential as an alternative to timothy hay because it grows well in the Mid-Atlantic region, is believed to have a similar nutrient quality to timothy, and is not as susceptible to cereal rust mite. Eleven mature, stalled Thoroughbred geldings (549 +/- 12.1 kg) that were exercised daily were used to compare voluntary DMI and apparent nutrient DM digestibility of timothy and low-alkaloid Chiefton variety reed canarygrass hay. Horses were paired by age and BW and randomly assigned to timothy or reed canarygrass hay during a 14-d period to measure voluntary DMI followed by a 4-d period to measure apparent DM digestibility. Both hays met the minimum requirements for DE, CP, Ca, P, K, Fe, and Mn, but they did not meet the minimum requirements for Cu, Zn, and Na for horses at maintenance and averaging 550 kg of BW. Timothy hay seemed to have a lower CP concentration (14.4%) compared with reed canarygrass hay (17.1%) and a more desirable Ca:P ratio at 1.6:1 compared with 0.8:1 for reed canarygrass hay. Horses fed timothy consumed more hay (P <0.001) during the voluntary DMI period compared with horses fed reed canarygrass. Greater voluntary DMI of timothy occurred on d 1, 3, and 5 (P <0.05), but DMI was similar for other days. Apparent DM digestibility was greater in horses fed timothy hay by 9.6% compared with horses fed reed canarygrass hay (P <0.05). Horses fed timothy had greater DM digestibility of ADF (P = 0.001), NDF (P = 0.001), sugar (P = 0.05), and Ca (P = 0.001) but lower apparent DM digestibility of CP (P = 0.012) and crude fat (P = 0.004). Timothy hay was superior in voluntary DMI and apparent DM digestibility compared with low-alkaloid reed canarygrass hay fed to horses. |
| Address |
Department of Animal and Avian Sciences, University of Maryland, College Park 20742, USA. amyburk@umd.edu |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1525-3163 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:17032805 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4236 |
| Permanent link to this record |
