| Records |
| Author |
Passler, S.; Pfeffer, M. |
| Title |
Detection of antibodies to alphaviruses and discrimination between antibodies to eastern and western equine encephalitis viruses in rabbit sera using a recombinant antigen and virus-specific monoclonal antibodies |
Type |
Journal Article |
| Year |
2003 |
Publication |
Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health |
Abbreviated Journal |
J Vet Med B Infect Dis Vet Public Health |
| Volume |
50 |
Issue |
6 |
Pages |
265-269 |
| Keywords |
Animals; Antibodies, Monoclonal/*immunology; Antibodies, Viral/*analysis/blood; DNA Primers; Encephalitis Virus, Eastern Equine/genetics/*immunology; Encephalitis Virus, Western Equine/genetics/*immunology; Encephalomyelitis, Equine/*diagnosis/*virology; Epitopes; Fluorescent Antibody Technique/*veterinary; Horses; Rabbits; Recombination, Genetic; Reverse Transcriptase Polymerase Chain Reaction/veterinary |
| Abstract |
Three arthropod-borne alphaviruses, western equine encephalitis viruses (WEEV), eastern equine encephalitis viruses (EEEV) and Venezuelan equine encephalitis viruses are the aetiological agents of a sometimes severe encephalomyelitis in equines and humans in the New World. With regard to the different ecology and epidemiology of these viruses, a method applied in serological screening should be able to distinguish between them as well as other related members of the genus Alphavirus in the American continent. However, this has been hampered in the past by (a) the close antigenic relationship between alphaviruses in traditional serological assays, especially in the routinely used haemagglutination-inhibition, and (b) the need of biosafety level 3 facilities to grow the viral antigens. An epitope blocking assay using an EEEV glycoprotein E1-expressing recombinant Sindbis virus and virus-specific monoclonal antibodies (mAbs) binding to the E1 of EEEV (strain NJ/60) and the E1 of Sindbis virus was established using automated flow cytometry. The test was evaluated using sera of infected and vaccinated rabbits. A cut-off value of 30% inhibition for antigenic complex-specific seroconversion was found to be sufficient for the detection of the respective infection. By using three different mAbs in parallel, we were able to detect alphavirus genus-, EEEV- and WEEV-complex-specific serum antibodies. As this test is based on the inhibition of binding of virus-specific mAbs, sera of every origin other than mouse can be tested. Thus, this assay may prove useful in the serological screening of a variety of animal species during an outbreak investigation. |
| Address |
Institute for Medical Microbiology, Infectious and Epidemic Diseases, Veterinary Faculty, Ludwig-Maximilians-University, Munich, Germany |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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ISSN  |
0931-1793 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:14628996 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2639 |
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| Author |
Mellor, P.S.; Hamblin, C. |
| Title |
African horse sickness |
Type |
Journal Article |
| Year |
2004 |
Publication |
Veterinary Research |
Abbreviated Journal |
Vet Res |
| Volume |
35 |
Issue |
4 |
Pages |
445-466 |
| Keywords |
African Horse Sickness/epidemiology/*prevention & control/*transmission/virology; African horse sickness virus/pathogenicity; Animals; Culicidae; Europe/epidemiology; Horses; Insect Vectors |
| Abstract |
African horse sickness virus (AHSV) causes a non-contagious, infectious insect-borne disease of equids and is endemic in many areas of sub-Saharan Africa and possibly Yemen in the Arabian Peninsula. However, periodically the virus makes excursions beyond its endemic areas and has at times extended as far as India and Pakistan in the east and Spain and Portugal in the west. The vectors are certain species of Culicoides biting midge the most important of which is the Afro-Asiatic species C. imicola. This paper describes the effects that AHSV has on its equid hosts, aspects of its epidemiology, and present and future prospects for control. The distribution of AHSV seems to be governed by a number of factors including the efficiency of control measures, the presence or absence of a long term vertebrate reservoir and, most importantly, the prevalence and seasonal incidence of the major vector which is controlled by climate. However, with the advent of climate-change the major vector, C. imicola, has now significantly extended its range northwards to include much of Portugal, Spain, Italy and Greece and has even been recorded from southern Switzerland. Furthermore, in many of these new locations the insect is present and active throughout the entire year. With the related bluetongue virus, which utilises the same vector species of Culicoides this has, since 1998, precipitated the worst outbreaks of bluetongue disease ever recorded with the virus extending further north in Europe than ever before and apparently becoming endemic in that continent. The prospects for similar changes in the epidemiology and distribution of AHSV are discussed. |
| Address |
Institute for Animal Health, Department of Arbovirology, Pirbright Laboratory, Ash Rd., Pirbright, Woking, Surrey, GU24 0NF, United Kingdom. philip.mellor@bbsrc.ac.uk |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0928-4249 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:15236676 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2358 |
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| Author |
Mellor, P.S. |
| Title |
African horse sickness: transmission and epidemiology |
Type |
Journal Article |
| Year |
1993 |
Publication |
Veterinary Research |
Abbreviated Journal |
Vet Res |
| Volume |
24 |
Issue |
2 |
Pages |
199-212 |
| Keywords |
Africa, Northern/epidemiology; African Horse Sickness/epidemiology/*transmission; African horse sickness virus/*physiology; Animals; Arachnid Vectors/microbiology; Ceratopogonidae/*microbiology; Culicidae/microbiology; Horses; Insect Vectors/*microbiology; Portugal/epidemiology; Spain/epidemiology; Ticks/microbiology |
| Abstract |
African horse sickness (AHS) virus causes a non-contagious, infectious, arthropod-borne disease of equines and occasionally of dogs. The virus is widely distributed across sub-Saharan African where it is transmitted between susceptible vertebrate hosts by the vectors. These are usually considered to be species of Culicoides biting midges but mosquitoes and/or ticks may also be involved to a greater or lesser extent. Periodically the virus makes excursions beyond its sub-Saharan enzootic zones but until recently does not appear to have been able to maintain itself outside these areas for more than 2-3 consecutive years at most. This is probably due to a number of factors including the apparent absence of a long term vertebrate reservoir, the prevalence and seasonal incidence of the vectors and the efficiency of control measures (vaccination and vector abatement). The recent AHS epizootics in Iberia and N Africa spanning as they do, 5 or more yr, seem to have established a new pattern in AHS virus persistence. This is probably linked to the continuous presence of adult C imicola in the area. Culicoides imicola is basically an Afro-Asiatic insect and prefers warm climates. Therefore its continuous adult presence in parts of Iberia and N Africa may be due to some recent moderations of the climate in these areas. |
| Address |
Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0928-4249 |
ISBN |
|
Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:8102076 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2359 |
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| Author |
Macphail, E.M. |
| Title |
Cognitive function in mammals: the evolutionary perspective |
Type |
Journal Article |
| Year |
1996 |
Publication |
Brain research. Cognitive brain research |
Abbreviated Journal |
Brain Res Cogn Brain Res |
| Volume |
3 |
Issue |
3-4 |
Pages |
279-290 |
| Keywords |
Animals; Cognition/*physiology; Conditioning (Psychology)/*physiology; Evolution; Humans; Learning/*physiology; Task Performance and Analysis |
| Abstract |
The work of behavioural pharmacologists has concentrated on small animals, such as rodents and pigeons. The validity of extrapolation of their findings to humans depends upon the existence of parallels in both physiology and psychology between these animals and humans. This paper considers the question whether there are in fact substantial cognitive parallels between, first, different non-human groups of vertebrates and, second, non-humans and humans. Behavioural data from 'simple' tasks, such as habituation and conditioning, do not point to species differences among vertebrates. Using examples that concentrate on the performance of rodents and birds, it is argued that, similarly, data from more complex tasks (learning-set formation, transitive inference, and spatial memory serve as examples) reveal few if any cognitive differences amongst non-human vertebrates. This conclusion supports the notion that association formation may be the critical problem-solving process available to non-human animals; associative mechanisms are assumed to have evolved to detect causal links between events, and would therefore be relevant in all ecological niches. In agreement with this view, recent advances in comparative neurology show striking parallels in functional organisation of mammalian and avian telencephalon. Finally, it is argued that although the peculiarly human capacity for language marks a large cognitive contrast between humans and non-humans, there is good evidence-in particular, from work on implicit learning--that the learning mechanisms available to non--humans are present and do play an important role in human cognition. |
| Address |
Department of Psychology, University of York at Heslington, UK |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
|
| ISSN |
0926-6410 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:8806029 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
603 |
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| Author |
Khalil, A.M.; Murakami, N.; Kaseda, Y. |
| Title |
Relationship between plasma testosterone concentrations and age, breeding season and harem size in Misaki feral horses |
Type |
Journal Article |
| Year |
1998 |
Publication |
The Journal of veterinary medical science / the Japanese Society of Veterinary Science |
Abbreviated Journal |
J Vet Med Sci |
| Volume |
60 |
Issue |
5 |
Pages |
643-645 |
| Keywords |
Age Factors; Animals; Animals, Wild; *Horses; Japan; Male; Reproduction; Seasons; Sexual Behavior, Animal; Sexual Maturation; *Social Behavior; Testosterone/*blood |
| Abstract |
Jugular vein blood samples were collected from 23 young and sexual mature feral stallions to examine the relationship between plasma testosterone concentration and age, breeding season or harem size. Testosterone concentration increased with the age of the stallions until they formed their own harems, at about 4 to 6 years old. Seasonal variations in testosterone concentrations were observed, and found to be significantly higher (P<0.001) throughout the breeding season than non-breeding season, from 3 years of age. Testosterone levels were correlated with harem size for individual stallions. It can be inferred from these results that there is a relationship between plasma testosterone concentration and age, breeding season and harem size. |
| Address |
Laboratory of Animal Behavioral Science, Faculty of Agriculture, Miyazaki University, Japan |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0916-7250 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:9637303 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
137 |
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| Author |
Carmalt, J.L.; Carmalt, K.P.; Barber, S.M. |
| Title |
The effect of occlusal equilibration on sport horse performance |
Type |
Journal Article |
| Year |
2006 |
Publication |
Journal of Veterinary Dentistry |
Abbreviated Journal |
J Vet Dent |
| Volume |
23 |
Issue |
4 |
Pages |
226-230 |
| Keywords |
Analysis of Variance; Animals; Cross-Over Studies; *Dental Occlusion, Balanced; Horse Diseases/*therapy; Horses; Malocclusion/therapy/*veterinary; Occlusal Adjustment/methods/*veterinary; Prospective Studies; Treatment Outcome |
| Abstract |
The objective of this study was to investigate the effect of routine dental occlusal equilibration treatment on dressage horse performance. Sixteen horses (11 treated; 5 untreated) ridden by a single rider performed a standardized dressage test twice and were scored by two experienced dressage judges according to recognized movements and rider cues. All horses were sedated and a full-mouth speculum was used to facilitate a complete oral examination. Treated horses had dental equilibration performed using a motorized dental instrument. The horses performed a second test 48-hours after dental equilibration, exactly as the baseline test, with the judges and rider blinded as to treatment group. The total test score as well as the individual movement scores were evaluated for equality of variance and statistical tests were applied to determine the influence of treatment. There was no significant improvement in the test score of horses that had received occlusal equilibration. |
| Address |
Scone Veterinary Hospital, NSW, Australia. carmalt_vet@hotmail.com |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0898-7564 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:17286128 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
3708 |
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| Author |
de Waal, F.B.; Uno, H.; Luttrell, L.M.; Meisner, L.F.; Jeannotte, L.A. |
| Title |
Behavioral retardation in a macaque with autosomal trisomy and aging mother |
Type |
Journal Article |
| Year |
1996 |
Publication |
American journal of mental retardation : AJMR |
Abbreviated Journal |
Am J Ment Retard |
| Volume |
100 |
Issue |
4 |
Pages |
378-390 |
| Keywords |
Animals; *Behavior, Animal; Brain/physiopathology; Female; Hydrocephalus/complications; Longitudinal Studies; Macaca mulatta/*genetics; Magnetic Resonance Imaging; Male; *Maternal Age; Psychomotor Disorders/*etiology; Social Behavior; Trisomy/*genetics; X Chromosome |
| Abstract |
The social development of a female rhesus monkey (Macaca mulatta) was followed from the day of birth until her death, at age 32 months. The subject, born to an older mother, had an extra autosome (karyotype: 43, XX, +18), an affliction that came about spontaneously. MRI scans revealed that she was also hydrocephalic. Compared to 23 female monkeys growing up under identical conditions, the subject showed serious motor deficiencies, a dramatic delay in the development of social behavior, poorly established dominance relationships, and greater than usual dependency on mother and kin. The subject was well-integrated into the social group, however. |
| Address |
University of Wisconsin-Madison, USA |
| Corporate Author |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0895-8017 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:8718992 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
205 |
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| Author |
Nicol, C.J.; Adachi, M.; Akiyama, T.E.; Gonzalez, F.J. |
| Title |
PPARgamma in endothelial cells influences high fat diet-induced hypertension |
Type |
Journal Article |
| Year |
2005 |
Publication |
American journal of hypertension : journal of the American Society of Hypertension |
Abbreviated Journal |
Am J Hypertens |
| Volume |
18 |
Issue |
4 Pt 1 |
Pages |
549-556 |
| Keywords |
Administration, Oral; Animals; Antihypertensive Agents/pharmacology; Blood Pressure/drug effects; Diabetes Mellitus, Type 2/physiopathology; Dietary Fats/*administration & dosage/pharmacology; Dose-Response Relationship, Drug; Endothelial Cells/*metabolism; Female; Heart Rate/drug effects; Hypertension/*etiology; Ligands; Male; Mice; Mice, Knockout; PPAR gamma/*metabolism; Sodium Chloride/administration & dosage/pharmacology; Thiazolidinediones/pharmacology |
| Abstract |
BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands improve human hypertension. However, the mechanism and site of this effect remains unknown, confounded by PPARgamma expression in many cell types, including endothelial cells (ECs). METHODS: To evaluate the vascular role of PPARgamma we used a conditional null mouse model. Specific disruption of PPARgamma in ECs was created by crossing Tie2-Cre+ transgenic (T2T+) and PPARgamma-floxed (fl/fl) mice to generate PPARgamma (fl/fl)T2T+ (PPARgamma E-null) mice. Conscious 8- to 12-week-old congenic PPARgamma (fl/fl)Cre- (wild type) and PPARgamma E-null mice were examined for changes in systolic blood pressure (BP) and heart rate (HR), untreated, after 2 months of salt-loading (drinking water), and after treatment for 3 months with high fat (HF) diet alone or supplemented during the last 2 weeks with rosiglitazone (3 mg/kg/d). RESULTS: Untreated PPARgamma E-nulls were phenotypically indistinguishable from wild-type littermates. However, compared to similarly treated wild types, HF-treated PPARgamma E-nulls had significantly elevated systolic BP not seen after normal diet or salt-loading. Despite sex-dependent baseline differences, salt-loaded and HF-treated PPARgamma E-nulls of either sex had significantly elevated HR versus wild types. Interestingly, rosiglitazone improved serum insulin levels, but not HF diet-induced hypertension, in PPARgamma E-null mice. CONCLUSIONS: These results suggest that PPARgamma in ECs not only is an important regulator of hypertension and HR under stressed conditions mimicking those arising in type 2 diabetics, but also mediates the antihypertensive effects of rosiglitazone. These data add evidence supporting a beneficial role for PPARgamma-specific ligands in the treatment of hypertension, and suggest therapeutic strategies targeting ECs may prove useful. |
| Address |
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0895-7061 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:15831367 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
69 |
| Permanent link to this record |
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| Author |
Grubb, T.L.; Foreman, J.H.; Benson, G.J.; Thurmon, J.C.; Tranquilli, W.J.; Constable, P.D.; Olson, W.O.; Davis, L.E. |
| Title |
Hemodynamic effects of calcium gluconate administered to conscious horses |
Type |
Journal Article |
| Year |
1996 |
Publication |
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine |
Abbreviated Journal |
J Vet Intern Med |
| Volume |
10 |
Issue |
6 |
Pages |
401-404 |
| Keywords |
Animals; Blood Pressure/drug effects/physiology; Calcium/blood; Calcium Gluconate/administration & dosage/*pharmacology; Cardiac Output/drug effects/physiology; Consciousness/*physiology; Dose-Response Relationship, Drug; Female; Heart Rate/drug effects/physiology; Hemodynamic Processes/*drug effects/physiology; Horses/blood/*physiology; Infusions, Intravenous; Male; Myocardial Contraction/drug effects/physiology; Respiration/drug effects/physiology; Stroke Volume/drug effects/physiology; Time Factors |
| Abstract |
Calcium gluconate was administered to conscious horses at 3 different rates (0.1, 0.2, and 0.4 mg/kg/min for 15 minutes each). Serum calcium concentrations and parameters of cardiovascular function were evaluated. All 3 calcium administration rates caused marked increases in both ionized and total calcium concentrations, cardiac index, stroke index, and cardiac contractility (dP/dtmax). Mean arterial pressure and right atrial pressure were unchanged; heart rate decreased markedly during calcium administration. Ionized calcium concentration remained between 54% and 57% of total calcium concentration throughout the study. We conclude that calcium gluconate can safely be administered to conscious horses at 0.1 to 0.4 mg/kg/min and that administration will result in improved cardiac function. |
| Address |
Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, USA |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0891-6640 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:8947873 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
97 |
| Permanent link to this record |
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| Author |
Naylor, J.M.; Poirier, K.L.; Hamilton, D.L.; Dowling, P.M. |
| Title |
The effects of feeding and fasting on gastrointestinal sounds in adult horses |
Type |
Journal Article |
| Year |
2006 |
Publication |
Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine |
Abbreviated Journal |
J Vet Intern Med |
| Volume |
20 |
Issue |
6 |
Pages |
1408-1413 |
| Keywords |
Animals; Auscultation/methods/*veterinary; *Digestive Physiology; Fasting/*physiology; Gastrointestinal Motility/physiology; Gastrointestinal Transit/physiology; Horses/*physiology; Postprandial Period/*physiology; Sound |
| Abstract |
The effect of changes in feed intake on auscultatable gastrointestinal sounds has not been systematically studied. Disagreement also is present in the literature about variation in sounds according to the quadrant of auscultation. Gastrointestinal sounds were recorded over the center of the left dorsal, left ventral, right ventral, and right dorsal quadrants and over the middle of the right abdominal flank. During 24 hours (n = 4) or 48 hours (n = 5) of fasting, there was a reduction in the intensity of gastrointestinal sounds as assessed by analysis of sound recordings. There was also a reduction in the number of mixing-like and propulsive-like sounds heard by 2 blinded observers. After refeeding, there was a marked increase in sound. Sound intensity varied among abdominal quadrants, but blinded observers did not notice significant differences in the number of mixing-like sounds. The left dorsal quadrant was quieter than others during fasting and refeeding. The right ventral quadrant appeared to be least affected by fasting, and sounds were louder over the right ventral and right middle quadrants than over the others. The blinded observers' perceptions of sound correlated poorly with one another and with objective measures of sound intensity. This experiment demonstrates the effectiveness of computerized analysis of abdominal sound in detecting a reduction in the intensity of gastrointestinal sounds during fasting and their return during refeeding. The left dorsal quadrant was quieter than other quadrants, likely because of its position over the small colon. There was considerable observer variation in the number of intestinal sounds heard. |
| Address |
Department of Clinical Sciences, Ross University School of Veterinary Medicine, Basseterre, St Kitts, West Indies. jnaylor@rossvet.edu.kn |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0891-6640 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:17186858 |
Approved |
no |
| Call Number |
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Serial |
1844 |
| Permanent link to this record |
