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Stuber, G.D.; Sparta, D.R.; Stamatakis, A.M.; van Leeuwen, W.A.; Hardjoprajitno, J.E.; Cho, S.; Tye, K.M.; Kempadoo, K.A.; Zhang, F.; Deisseroth, K.; Bonci, A. |
![goto web page (via DOI) doi](img/doi.gif)
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Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking |
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2011 |
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Nature |
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advance online publication |
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The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence1, 2, 3, 4, 5, 21, 22, 23. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours4, 6, 7, 24, 25, but our understanding of the interaction between these two brain regions has been limited by the inability to manipulate neural-circuit elements of this pathway selectively during behaviour. To circumvent this limitation, we used in vivo optogenetic stimulation or inhibition of glutamatergic fibres from the BLA to the NAc, coupled with intracranial pharmacology and ex vivo electrophysiology. Here we show that optical stimulation of the pathway from the BLA to the NAc in mice reinforces behavioural responding to earn additional optical stimulation of these synaptic inputs. Optical stimulation of these glutamatergic fibres required intra-NAc dopamine D1-type receptor signalling, but not D2-type receptor signalling. Brief optical inhibition of fibres from the BLA to the NAc reduced cue-evoked intake of sucrose, demonstrating an important role of this specific pathway in controlling naturally occurring reward-related behaviour. Moreover, although optical stimulation of glutamatergic fibres from the medial prefrontal cortex to the NAc also elicited reliable excitatory synaptic responses, optical self-stimulation behaviour was not observed by activation of this pathway. These data indicate that whereas the BLA is important for processing both positive and negative affect, the glutamatergic pathway from the BLA to the NAc, in conjunction with dopamine signalling in the NAc, promotes motivated behavioural responding. Thus, optogenetic manipulation of anatomically distinct synaptic inputs to the NAc reveals functionally distinct properties of these inputs in controlling reward-seeking behaviours. |
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Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. |
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1476-4687 |
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10.1038/nature10194 |
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Equine Behaviour @ team @ |
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5398 |
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Ramsden, S.; Richardson, F.M.; Josse, G.; Thomas, M.S.C.; Ellis, C.; Shakeshaft, C.; Seghier, M.L.; Price, C.J. |
![goto web page (via DOI) doi](img/doi.gif)
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Verbal and non-verbal intelligence changes in the teenage brain |
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2011 |
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Intelligence quotient (IQ) is a standardized measure of human intellectual capacity that takes into account a wide range of cognitive skills1. IQ is generally considered to be stable across the lifespan, with scores at one time point used to predict educational achievement and employment prospects in later years1. Neuroimaging allows us to test whether unexpected longitudinal fluctuations in measured IQ are related to brain development. Here we show that verbal and non-verbal IQ can rise or fall in the teenage years, with these changes in performance validated by their close correlation with changes in local brain structure. A combination of structural and functional imaging showed that verbal IQ changed with grey matter in a region that was activated by speech, whereas non-verbal IQ changed with grey matter in a region that was activated by finger movements. By using longitudinal assessments of the same individuals, we obviated the many sources of variation in brain structure that confound cross-sectional studies. This allowed us to dissociate neural markers for the two types of IQ and to show that general verbal and non-verbal abilities are closely linked to the sensorimotor skills involved in learning. More generally, our results emphasize the possibility that an individual’s intellectual capacity relative to their peers can decrease or increase in the teenage years. This would be encouraging to those whose intellectual potential may improve, and would be a warning that early achievers may not maintain their potential. |
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Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. |
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1476-4687 |
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10.1038/nature10514 |
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Equine Behaviour @ team @ |
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5422 |
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Balendra, G.; Turner, M.; McCrory, P.; Halley, W. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Injuries in amateur horse racing (point to point racing) in Great Britain and Ireland during 1993-2006 |
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Journal Article |
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2007 |
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British Journal of Sports Medicine |
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Br J Sports Med |
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41 |
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3 |
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162-166 |
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OBJECTIVES: To provide a breakdown of injury incidence from amateur jump racing (also known as point to point racing) in Great Britain and Ireland during 1993-2006 and to compare the injury epidemiology with professional horse racing in Great Britain, Ireland and France. DESIGN: Retrospective review. SETTING: Great Britain and Ireland. PARTICIPANTS: Amateur jockeys. MAIN OUTCOME MEASURES: Injury rates. RESULTS: Injury data suggest that point to point racing is more dangerous from an injury point of view than professional jump racing, which has previously been shown to be more dangerous than flat racing. Amateur jockeys have more falls than their professional counterparts, and this in turn puts them at greater risk of sustaining more serious injuries. CONCLUSIONS: Amateur (point to point) jockeys represent a sporting population that previously has been little studied. They represent a group at high risk of injury, and hence formal injury surveillance tracking and counter measures for injury prevention are recommended. |
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University of Melbourne, Melbourne, Victoria, Australia |
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1473-0480 |
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PMID:17138629 |
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refbase @ user @ |
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3821 |
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Rands, S.A.; Cowlishaw, G.; Pettifor, R.A.; Rowcliffe, J.M.; Johnstone, R.A. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
The emergence of leaders and followers in foraging pairs when the qualities of individuals differ |
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Journal Article |
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2008 |
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BMC Evolutionary Biology |
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BMC Evol Biol |
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8 |
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51 |
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Animals; *Feeding Behavior; *Food Chain; *Models, Biological; *Social Dominance |
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BACKGROUND: Foraging in groups offers animals a number of advantages, such as increasing their likelihood of finding food or detecting and avoiding predators. In order for a group to remain together, there has to be some degree of coordination of behaviour and movement between its members (which may in some cases be initiated by a decision-making leader, and in other cases may emerge as an underlying property of the group). For example, behavioural synchronisation is a phenomenon where animals within a group initiate and then continue to conduct identical behaviours, and has been characterised for a wide range of species. We examine how a pair of animals should behave using a state-dependent approach, and ask what conditions are likely to lead to behavioural synchronisation occurring, and whether one of the individuals is more likely to act as a leader. RESULTS: The model we describe considers how the energetic gain, metabolic requirements and predation risks faced by the individuals affect measures of their energetic state and behaviour (such as the degree of behavioural synchronisation seen within the pair, and the value to an individual of knowing the energetic state of its colleague). We explore how predictable changes in these measures are in response to changes in physiological requirements and predation risk. We also consider how these measures should change when the members of the pair are not identical in their metabolic requirements or their susceptibility to predation. We find that many of the changes seen in these measures are complex, especially when asymmetries exist between the members of the pair. CONCLUSION: Analyses are presented that demonstrate that, although these general patterns are robust, care needs to be taken when considering the effects of individual differences, as the relationship between individual differences and the resulting qualitative changes in behaviour may be complex. We discuss how these results are related to experimental observations, and how the model and its predictions could be extended. |
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Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. sean.rands@bristol.ac.uk |
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1471-2148 |
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PMID:18282297 |
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Equine Behaviour @ team @ |
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5126 |
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Dong, D.; Jones, G.; Zhang, S. |
![goto web page (via DOI) doi](img/doi.gif)
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Dynamic evolution of bitter taste receptor genes in vertebrates |
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Journal Article |
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2009 |
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BMC Evolutionary Biology |
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9 |
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1 |
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12 |
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Sensing bitter tastes is crucial for many animals because it can prevent them from ingesting harmful foods. This process is mainly mediated by the bitter taste receptors (T2R), which are largely expressed in the taste buds. Previous studies have identified some T2R gene repertoires, and marked variation in repertoire size has been noted among species. However, the mechanisms underlying the evolution of vertebrate T2R genes remain poorly understood. |
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1471-2148 |
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Equine Behaviour @ team @ Dong2009 |
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6637 |
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Rizzolatti, G.; Fogassi, L.; Gallese, V. |
![goto web page (via DOI) doi](img/doi.gif)
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Neurophysiological mechanisms underlying the understanding and imitation of action |
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2001 |
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Nature Reviews Neuroscience |
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Nat Rev Neurosci |
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2 |
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9 |
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661-670 |
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What are the neural bases of action understanding? Although this capacity could merely involve visual analysis of the action, it has been argued that we actually map this visual information onto its motor representation in our nervous system. Here we discuss evidence for the existence of a system, the ‘mirror system’, that seems to serve this mapping function in primates and humans, and explore its implications for the understanding and imitation of action. |
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1471-003x |
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10.1038/35090060 |
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Equine Behaviour @ team @ |
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5013 |
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Mace, G.M.; Harvey, P.H.; Clutton-Brock, T.H. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Title |
Brain size and ecology in small mammals |
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Journal Article |
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1981 |
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Journal of Zoology |
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J Zool |
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193 |
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3 |
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333-354 |
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Relative brain size (measured as gross brain size after body size effects are removed) differs systematically between families of rodents, insectivores and lagomorphs. The Sciuridae have the largest relative brain size, the Soricidae and Bathyergidae the smallest. These results are discussed and compared with previous analyses of relative brain sizes among primates and bats. These differences complicate comparisons between relative brain size across phylogenetically diverse species and attempts to relate differences in relative brain size to ecological variables. To overcome these problems, best fit relationships were estimated for each family, and values for each genus were expressed as deviations from the lines of best fit. We refer to these values as Comparative Brain Size (CBS). Differences in CBS are related to differences in habitat type (forest-dwelling genera have larger CBS' than grassland forms), in diet (folivores have smaller CBS' than generalists or insectivores, frugivores and granivores), in zonation (arboreal genera have larger CBS' than terrestrial ones) and in activity timing (nocturnal genera have larger CBS' than dirurnal ones). However, these ecological categories are interrelated and, when the effects of other ecological differences are taken into account using analyses of variance, only the differences associated with diet, and possibly habitat remain. |
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Blackwell Publishing Ltd |
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1469-7998 |
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Equine Behaviour @ team @ |
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5455 |
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Schino, G.; Aureli, F. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Reciprocity in group-living animals: partner control versus partner choice |
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Journal Article |
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2016 |
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Biological Reviews |
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Biol Rev |
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92 |
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2 |
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665-672 |
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cooperation; reciprocity; partner control; partner choice; proximate mechanisms |
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ABSTRACT Reciprocity is probably the most debated of the evolutionary explanations for cooperation. Part of the confusion surrounding this debate stems from a failure to note that two different processes can result in reciprocity: partner control and partner choice. We suggest that the common observation that group-living animals direct their cooperative behaviours preferentially to those individuals from which they receive most cooperation is to be interpreted as the result of the sum of the two separate processes of partner control and partner choice. We review evidence that partner choice is the prevalent process in primates and propose explanations for this pattern. We make predictions that highlight the need for studies that separate the effects of partner control and partner choice in a broader variety of group-living taxa. |
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Wiley/Blackwell (10.1111) |
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1464-7931 |
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doi: 10.1111/brv.12248 |
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Equine Behaviour @ team @ |
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6411 |
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Ben-Shlomo, G.; Plummer, C.; Barrie, K.; Brooks, D. |
![goto web page (via DOI) doi](img/doi.gif)
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Title |
Characterization of the normal dark adaptation curve of the horse |
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Journal Article |
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2012 |
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Veterinary Ophthalmology |
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15 |
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1 |
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42-45 |
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adaptation; curve; dark; electroretinography; equine; scotopic |
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Objective The goal of this work is to study the dark adaptation curve of the normal horse electroretinogram (ERG). Procedures The electroretinographic responses were recorded from six healthy female ponies using a contact lens electrode and a mini-Ganzfeld electroretinographic unit. The horses were sedated intravenously with detomidine, an auriculopalpebral nerve block was then performed, and the pupil was fully dilated. The ERG was recorded in response to a low intensity light stimulus (30 mcd.s/m2) that was given at times (T) T = 5, 10, 15, 20, 25, 30, 40, 50, and 60 min of dark adaptation. Off-line analysis of the ERG was then performed. Results Mean b-wave amplitude of the full-field ERG increased continuously from 5 to 25 min of dark adaptation. The b-wave amplitude peaked at T = 25, however, there was no statistical significance between T = 20 and T = 25. The b-wave amplitude then remained elevated with no significant changes until the end of the study at T = 60 (P > 0.49). The b-wave implicit time increased continuously between T = 5 and T = 20, then gradually decreased until T = 60. No distinct a-wave was observed during the testing time. Conclusions Evaluation of horse rod function or combined rod/cone function by means of full-field ERG should be performed after a minimum 20 min of dark adaptation. |
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Blackwell Publishing Ltd |
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1463-5224 |
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Equine Behaviour @ team @ |
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5626 |
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Author |
Hurn, S.D.; Turner, A.G. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Title |
Ophthalmic examination findings of Thoroughbred racehorses in Australia |
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Journal Article |
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2006 |
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Veterinary Ophthalmology |
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Vet Ophthalmol |
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9 |
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2 |
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95-100 |
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Animals; Cataract/epidemiology/veterinary; Diagnostic Techniques, Ophthalmological/veterinary; Eye Diseases/diagnosis/epidemiology/*veterinary; Female; Horse Diseases/diagnosis/*epidemiology; Horses; Male; Prevalence; Victoria/epidemiology |
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OBJECTIVE: To record the prevalence and document the types of eye disease in population of Thoroughbred racehorses in Victoria, Australia. DESIGN: Prospective study. ANIMALS: Two hundred four Thoroughbred racehorses. PROCEDURE: All horses and both eyes were examined at four metropolitan and two country racing stable complexes. Ophthalmic exam was performed following dark adaptation with a transilluminator, biomicroscope, and direct ophthalmoscope. Intraocular pressures were measured when indicated. Both pupils were dilated with tropicamide when indicated. RESULTS: One hundred eighty-two (89.2%) flat-racing and 22 (10.8%) jump-racing (hurdle or steeple) horses were examined. Age range: 2-9 years (mean 3.7 years, median 3); 97 (47.5%) male-neuter, 74 (36. 3%) female, 33 (16.2%) male. Potential vision-threatening eye disease was present in 15 (7.4%) different horses: complete lenticular cataracts 3, posterior lens luxation and cataract 1, large peripapillary 'butterfly' inactive lesions 3, large peripapillary 'butterfly' active lesions 2, peripapillary focal inactive 'bullet hole' chorioretinal lesions (> 20) 5, optic nerve atrophy 1. Non-vision threatening eye disease was present in 117 (57.4%) different horses, involving one or more ocular structures: lower eyelid scars 3; periocular fibropapillomatous disease 1; third eyelid squamous cell carcinoma 1; corneal scars 6; corneal band opacity 2; anterior iris synechia 1; developmental cataracts 36 (17.2%); peripapillary focal inactive 'bullet hole' chorioretinal lesions (< 20) 103 (50.0%); linear peripapillary hyperpigmentation bands 16 (7.9%). Unusual variations of normal ocular anatomy and colobomata was recorded in 11 (5.4%) different horses: granular iridica hypoplasia 3, granular iridica hyperplasia 2, multilobular granular iridica cyst 1, microcornea 1, hyaloid remnant 1, rotated optic nerve head 1, coloboma of the lens 1, atypical coloboma of the retina 1. CONCLUSIONS: This survey demonstrates that the prevalence of vision-threatening eye disease in racing horses may be greater than previously perceived, and highlights the importance of ocular examination within any routine physical examination of horses. |
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All Animal Eye Services, Mount Waverley, Victoria, Australia. sdhurn@bigpond.com |
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1463-5216 |
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PMID:16497233 |
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no |
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Equine Behaviour @ team @ |
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3766 |
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