| Records |
| Author |
Elhay, M.; Newbold, A.; Britton, A.; Turley, P.; Dowsett, K.; Walker, J. |
| Title |
Suppression of behavioural and physiological oestrus in the mare by vaccination against GnRH |
Type |
Journal Article |
| Year |
2007 |
Publication |
Australian Veterinary Journal |
Abbreviated Journal |
Aust Vet J |
| Volume |
85 |
Issue |
1-2 |
Pages |
39-45 |
| Keywords |
Animals; Antibodies/blood; Estradiol/blood; *Estrus/drug effects/physiology; Female; Gonadotropin-Releasing Hormone/*immunology/*pharmacology; Horses/*physiology; Luteinizing Hormone/blood; Ovulation/*drug effects/physiology; Progesterone/blood; Safety; Sexual Behavior, Animal/drug effects/physiology; Time Factors; Vaccination/veterinary |
| Abstract |
OBJECTIVE: To examine the immunogenicity of an equine immunocontraceptive vaccine and its efficacy in controlling hormone-related behaviour. DESIGN: A total of 24 mares at two sites in Australia were vaccinated with an immunocontraceptive vaccine comprising gonadotrophin releasing hormone (GnRH) conjugated to a carrier protein in immunostimulating complex as an adjuvant. Twelve animals at each site received a placebo of adjuvant alone and served as controls for seasonal oestrus, hormonal and behaviour patterns. Animals were observed for injection site reactions, ovarian and follicular activity, and serum levels of antibody, 17beta-oestradiol and progesterone in the weeks following vaccination. Mares were also examined for oestrous behaviour by teasing with a stallion. RESULTS: All mares responded to vaccination. Two weeks following the second vaccination there was a peak in antibody response to GnRH that declined gradually over the following weeks. Commensurate with the elevated anti-GnRH antibody there was a marked effect on ovarian activity with a reduction in 17beta-oestradiol and progesterone levels in the 24 vaccinated mares. There was also a reduction of oestrus-related behaviour as determined by a teaser stallion. This effect lasted a minimum of 3 months and correlated with the initial level of antibody response. CONCLUSION: Following a conventional two-dose immunisation regime this commercially available equine immunocontraceptive vaccine was effective at inhibiting oestrous behaviour for at least 3 months. This vaccine has a high level of safety since there were no significant local reactions nor were there any adverse systemic responses to vaccination. |
| Address |
Veterinary Medicines Research and Development, Pfizer Animal Health, Parkville, VIC 3052. Martin.Elhay@pfizer.com |
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English |
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0005-0423 |
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| Notes |
PMID:17300452 |
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no |
| Call Number |
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Serial |
1831 |
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| Author |
Davies, H.M.S. |
| Title |
The timing and distribution of strains around the surface of the midshaft of the third metacarpal bone during treadmill exercise in one Thoroughbred racehorse |
Type |
Journal Article |
| Year |
2005 |
Publication |
Australian Veterinary Journal |
Abbreviated Journal |
Aust Vet J |
| Volume |
83 |
Issue |
3 |
Pages |
157-162 |
| Keywords |
Animals; Exercise Test/veterinary; Female; Gait/*physiology; Horses/*physiology; Metacarpus/*physiology; Motor Activity/physiology; Physical Conditioning, Animal/*physiology; Stress, Mechanical; Weight-Bearing/physiology |
| Abstract |
OBJECTIVE: To confirm that the midshaft dorsal cortex of the third metacarpal bone experienced higher compressive strains during fast exercise than the medial or lateral cortices, and that the strain peak occurred earlier in the hoof-down phase of the stride on the dorsal cortex than the medial or lateral cortices. DESIGN: Observations of a single horse. PROCEDURE: Strains were collected from a single, sound, 3-year-old Thoroughbred mare during treadmill exercise from rosette strain gauges implanted onto the medial, lateral and dorsal surfaces of the midshaft of the right cannon bone, simultaneously with data from a hoof switch that showed when the hoof was in the stance phase. RESULTS: Peak compressive strains on the dorsal surface of the third metacarpal bone were proportional to exercise speed and occurred at about 30% of stance. Peak compressive strains on the medial surface of the non-lead limb reached a maximum at a speed around 10 m/s and occurred at mid-stance. Peak compressive strains on the lateral surface varied in timing and size between strides at all exercise speeds, but remained less than -2000 microstrains. CONCLUSIONS: The timing of peak compressive strains on the dorsal cortex suggests a relationship to deceleration of the limb following hoof impact, so the main determinants of their size would be exercise speed and turning (as shown in previous experiments). This experiment confirms data from other laboratories that were published but not discussed, that peak compressive strains on the medial surface occur at mid-stance. This suggests that they are related to the support of body weight. The strains on the lateral cortex occurred at variable times so may be associated with the maintenance of balance as well as the support of body weight. Understanding the loading of the third metacarpal bone will help to determine causes of damage to it and ways in which the bone might be conditioned to prevent such damage. |
| Address |
Department of Veterinary Science, University of Melbourne, Parkville, Victoria 3010. h.davies@unimelb.edu.au |
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0005-0423 |
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| Notes |
PMID:15825628 |
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no |
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Serial |
1891 |
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| Author |
Pell, S.M.; McGreevy, P.D. |
| Title |
Prevalence of stereotypic and other problem behaviours in thoroughbred horses |
Type |
Journal Article |
| Year |
1999 |
Publication |
Australian Veterinary Journal |
Abbreviated Journal |
Aust Vet J |
| Volume |
77 |
Issue |
10 |
Pages |
678-679 |
| Keywords |
Animals; *Behavior, Animal; Breeding; Horse Diseases/*epidemiology; Horses/*psychology; New South Wales/epidemiology; Odds Ratio; Prevalence; *Stereotyped Behavior |
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| Address |
Department of Animal Science, University of Sydney, New South Wales |
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English |
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| ISSN |
0005-0423 |
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| Notes |
PMID:10590799 |
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no |
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refbase @ user @ |
Serial |
1927 |
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| Author |
Judge, N.G. |
| Title |
Transport of horses |
Type |
Journal Article |
| Year |
1969 |
Publication |
Australian Veterinary Journal |
Abbreviated Journal |
Aust Vet J |
| Volume |
45 |
Issue |
10 |
Pages |
465-469 |
| Keywords |
Aircraft; Animals; Australia; Automobiles; Behavior, Animal; Equipment and Supplies/veterinary; *Horses; Methods; *Movement; Ships; Veterinary Medicine |
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| ISSN |
0005-0423 |
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| Notes |
PMID:5408645 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
1968 |
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| Author |
[No authors listed] |
| Title |
African horse sickness--a serious disease |
Type |
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| Year |
2006 |
Publication |
Australian Veterinary Journal |
Abbreviated Journal |
Aust Vet J |
| Volume |
84 |
Issue |
5 |
Pages |
N24-5 |
| Keywords |
*African Horse Sickness/epidemiology/pathology/prevention & control/transmission; African horse sickness virus/pathogenicity; Animals; Australia/epidemiology; Disease Outbreaks/prevention & control/veterinary; *Equidae; Horses; Vaccination/veterinary |
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English |
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| ISSN |
0005-0423 |
ISBN |
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| Notes |
PMID:16739521 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2356 |
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| Author |
Gibson, K.T.; Burbidge, H.M.; Anderson, B.H. |
| Title |
Tendonitis of the branches of insertion of the superficial digital flexor tendon in horses |
Type |
Journal Article |
| Year |
1997 |
Publication |
Australian Veterinary Journal |
Abbreviated Journal |
Aust Vet J |
| Volume |
75 |
Issue |
4 |
Pages |
253-256 |
| Keywords |
Animals; Carpus, Animal/pathology/physiopathology/ultrasonography; Horse Diseases/*diagnosis/pathology/ultrasonography; Horses; Prognosis; Retrospective Studies; Tendinopathy/diagnosis/pathology/*veterinary; Tendon Injuries/diagnosis/pathology/veterinary; Tendons/pathology/physiopathology/ultrasonography; Ultrasonography/methods/veterinary |
| Abstract |
OBJECTIVE: To describe clinical findings, ultrasonographic features and outcome of injury to the branches of insertion of the superficial digital flexor (SDF) tendon in horses. DESIGN: Retrospective study of 14 cases. PROCEDURE: Fourteen Thoroughbred horses with tendonitis affecting the branches of insertion of the SDF tendon were examined for lameness, location and amount of swelling, and the presence of other musculoskeletal abnormalities. The flexor tendons were assessed by ultrasonographic examination, and recommendations were made for management of the cases. Outcome was assessed by re-examination of some horses, direct communication with the owner or trainer, and examination of race records. RESULTS: The lateral SDF branch was affected in 10 horses; the medial branch in three, and both branches in one horse. Two horses had concurrent injuries to the SDF tendon in the metacarpal region of the contralateral limb. Ultrasonographic findings included swelling of the affected SDF branch, peritendinous fluid accumulation, disruption of normal fibre alignment on sagittal scan, and variable loss of echogenicity. As healing occurred, there was return of normal echogenicity, but normal fibre alignment did not return completely and apparent adhesions formed between the affected SDF branch and adjacent structures. Seven of 10 horses which returned to their previous use were able to compete without further tendon injury. Recurrence of injury occurred in one case, and another two horses developed tendonitis in the metacarpal region. One horse was retired from racing but was able to compete at dressage without recurrence of injury. Two horses were retired for breeding without returning to training, and one horse was sold and lost to follow up but did not race. CONCLUSION: The prognosis is fair for return to previous use following injury to the branches of insertion of the SDF tendon in athletic horses. |
| Address |
Department of Veterinary Clinical Sciences, Massey University, Palmerston North, New Zealand |
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English |
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| ISSN |
0005-0423 |
ISBN |
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| Notes |
PMID:9140649 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
3739 |
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| Author |
Pearce, G.P.; May-Davis, S.; Greaves, D. |
| Title |
Femoral asymmetry in the Thoroughbred racehorse |
Type |
Journal Article |
| Year |
2005 |
Publication |
Australian Veterinary Journal |
Abbreviated Journal |
Aust Vet J |
| Volume |
83 |
Issue |
6 |
Pages |
367-370 |
| Keywords |
Animals; Cumulative Trauma Disorders/pathology/*veterinary; Femur/*pathology; Horse Diseases/*pathology/physiopathology; Horses; Locomotion; Physical Conditioning, Animal/*physiology |
| Abstract |
OBJECTIVE: To investigate the occurrence of geometrical asymmetries in the macro-architecture of left and right femurs from Thoroughbred racehorses previously used in competitive training and racing in New South Wales, Australia. METHODS: Detailed postmortem measurements were made of 37 characteristics of left and right femurs from eleven Thoroughbred racehorses euthanased for reasons unrelated to the study. Measurements focused on articulating surfaces and sites of attachment of muscles and ligaments known to be associated with hindlimb locomotion. RESULTS: Five measurements were significantly larger in left compared to right femurs (P < 0.05). The regions showing significant differences between left and right limbs were proximal cranial and overhead medio-lateral widths, greater trochanter depth, depth of the fovea in the femoral head and distal inter-epicondylar width. CONCLUSION: The left-right differences in femoral morphology were associated with sites of muscle and ligament attachment known to be involved with hindlimb function in negotiating turns. These differences may be the result of selection pressure for racing performance on curved race tracks and/or adaptations related to asymmetrical loading of the outside hindlimb associated with repeated negotiation of turns on such tracks. |
| Address |
Faculty of Rural Management, University of Sydney, Leeds Parade, Orange, New South Wales 2800. gpp28@cam.ac.uk |
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English |
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0005-0423 |
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| Notes |
PMID:15986917 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4036 |
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| Author |
Yamada, T.; Rojanasuphot, S.; Takagi, M.; Wungkobkiat, S.; Hirota, T. |
| Title |
Studies on an epidemic of Japanese encephalitis in the northern region of Thailand in 1969 and 1970 |
Type |
Journal Article |
| Year |
1971 |
Publication |
Biken Journal |
Abbreviated Journal |
Biken J |
| Volume |
14 |
Issue |
3 |
Pages |
267-296 |
| Keywords |
Adolescent; Adult; Animals; Arboviruses/immunology; Buffaloes; Cattle; Chickens; Child; Child, Preschool; Cross Reactions; Culicidae; Dengue Virus/immunology; Disease Outbreaks; Ducks; Ecology; Encephalitis Virus, Japanese/immunology/isolation & purification; Encephalitis, Japanese/cerebrospinal fluid/*epidemiology/immunology/microbiology/mortality; Female; Hemagglutination Inhibition Tests; Hemorrhagic Fevers, Viral/epidemiology; Horses; Humans; Infant; Male; Mice; Neutralization Tests; Swine; Thailand |
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English |
Summary Language |
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| ISSN |
0006-2324 |
ISBN |
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| Notes |
PMID:4400462 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2728 |
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| Author |
Hirota, S.; Suzuki, M.; Watanabe, Y. |
| Title |
Hydrophobic effect of trityrosine on heme ligand exchange during folding of cytochrome c |
Type |
Journal Article |
| Year |
2004 |
Publication |
Biochemical and Biophysical Research Communications |
Abbreviated Journal |
Biochem Biophys Res Commun |
| Volume |
314 |
Issue |
2 |
Pages |
452-458 |
| Keywords |
Amino Acids/chemistry; Animals; Cytochromes c/*chemistry; Heme/*chemistry; Histidine/chemistry; Horses; Hydrogen-Ion Concentration; Kinetics; Ligands; Myocardium/chemistry; Peptides/chemistry; Protein Folding; Spectrophotometry; Spectrum Analysis, Raman; Tyrosine/*analogs & derivatives/*chemistry |
| Abstract |
Effect of a hydrophobic peptide on folding of oxidized cytochrome c (cyt c) is studied with trityrosine. Folding of cyt c was initiated by pH jump from 2.3 (acid-unfolded) to 4.2 (folded). The Soret band of the 2-ms transient absorption spectrum during folding decreased its intensity and red-shifted from 397 to 400 nm by interaction with trityrosine, whereas tyrosinol caused no significant effect. The change in the transient absorption spectrum by interaction with trityrosine was similar to that obtained with 100 mM imidazole, which showed that the population of the intermediate His/His coordinated species increased during folding of cyt c by interaction with trityrosine. The absorption change was biphasic, the fast phase (82+/-9s(-1)) corresponding to the transition from the His/H(2)O to the His/Met coordinated species, whereas the slow phase (24+/-3s(-1)) from His/His to His/Met. By addition of trityrosine, the relative ratio of the slow phase increased, due to increase of the His/His species at the initial stage of folding. According to the resonance Raman spectra of cyt c, the high-spin 6-coordinate and low-spin 6-coordinate species were dominated at pH 2.3 and 4.2, respectively, and these species were not affected by addition of trityrosine. These results demonstrated that the His/His species increased by interaction with trityrosine at the initial stage of cyt c folding, whereas the heme coordination structure was not affected by trityrosine when the protein was completely unfolded or folded. Hydrophobic peptides thus may be useful to study the effects of hydrophobic interactions on protein folding. |
| Address |
Department of Physical Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, 607-8414 Kyoto, Japan. hirota@mb.kyoto-phu.ac.jp |
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English |
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0006-291X |
ISBN |
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| Notes |
PMID:14733927 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
3777 |
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| Author |
Bayley, P.; Martin, S.; Anson, M. |
| Title |
Temperature-jump circular dichroism: observation of chiroptical relaxation processes at millisecond time resolution |
Type |
Journal Article |
| Year |
1975 |
Publication |
Biochemical and Biophysical Research Communications |
Abbreviated Journal |
Biochem Biophys Res Commun |
| Volume |
66 |
Issue |
1 |
Pages |
303-308 |
| Keywords |
*Alcohol Oxidoreductases/metabolism; Animals; Circular Dichroism; Horses; Kinetics; Liver/enzymology; Mathematics; Protein Conformation; Temperature; Time Factors |
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English |
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Abbreviated Series Title |
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| ISSN |
0006-291X |
ISBN |
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| Notes |
PMID:1172440 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
3816 |
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