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Author Friederici, A.D.; Alter, K.
Title Lateralization of auditory language functions: a dynamic dual pathway model Type Journal Article
Year 2004 Publication Brain and Language Abbreviated Journal Brain Lang
Volume 89 Issue 2 Pages 267-276
Keywords Auditory Pathways/physiology; Brain Mapping; Comprehension/*physiology; Dominance, Cerebral/*physiology; Frontal Lobe/*physiology; Humans; Nerve Net/physiology; Phonetics; Semantics; Speech Acoustics; Speech Perception/*physiology; Temporal Lobe/*physiology
Abstract Spoken language comprehension requires the coordination of different subprocesses in time. After the initial acoustic analysis the system has to extract segmental information such as phonemes, syntactic elements and lexical-semantic elements as well as suprasegmental information such as accentuation and intonational phrases, i.e., prosody. According to the dynamic dual pathway model of auditory language comprehension syntactic and semantic information are primarily processed in a left hemispheric temporo-frontal pathway including separate circuits for syntactic and semantic information whereas sentence level prosody is processed in a right hemispheric temporo-frontal pathway. The relative lateralization of these functions occurs as a result of stimulus properties and processing demands. The observed interaction between syntactic and prosodic information during auditory sentence comprehension is attributed to dynamic interactions between the two hemispheres.
Address Max Planck Institute of Cognitive Neuroscience, P.O. Box 500 355, 04303 Leipzig, Germany. angelafr@cns.mpg.de
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0093-934X ISBN Medium
Area Expedition Conference
Notes PMID:15068909 Approved no
Call Number Equine Behaviour @ team @ Serial 4722
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Author Zentall, T.R.; Klein, E.D.; Singer, R.A.
Title Evidence for detection of one duration sample and default responding to other duration samples by pigeons may result from an artifact of retention-test ambiguity Type Journal Article
Year 2004 Publication Journal of experimental psychology. Animal behavior processes Abbreviated Journal J Exp Psychol Anim Behav Process
Volume 30 Issue 2 Pages 129-134
Keywords Animals; Artifacts; Association Learning; Columbidae; *Discrimination Learning; *Recognition (Psychology); *Retention (Psychology); *Time Perception; *Transfer (Psychology)
Abstract S. C. Gaitan and J. T. Wixted (2000) proposed that when pigeons are trained on a conditional discrimination to associate 1 duration sample with 1 comparison and 2 other duration samples with a 2nd comparison, they detect only the single duration, and on trials involving either of the 2 other duration samples, they respond to the other comparison by default. In 2 experiments, the authors show instead that pigeons lend to treat the retention intervals (such as those used by Gaitan and Wixted) as intertrial intervals, and thus, they tend to treat all trials with a delay as 0-s sample trials. The authors tested this hypothesis by showing that divergent retention functions do not appear when the retention interval is discriminably different from the intertrial interval.
Address Department of Psychology, University of Kentucky, Lexington, KY 40506-0044, USA. zentall@uky.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0097-7403 ISBN Medium
Area Expedition Conference
Notes PMID:15078122 Approved no
Call Number refbase @ user @ Serial 232
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Author Beran, M.J.; Pate, J.L.; Washburn, D.A.; Rumbaugh, D.M.
Title Sequential responding and planning in chimpanzees (Pan troglodytes) and rhesus macaques (Macaca mulatta) Type Journal Article
Year 2004 Publication Journal of Experimental Psychology. Animal Behavior Processes Abbreviated Journal J Exp Psychol Anim Behav Process
Volume 30 Issue 3 Pages 203-212
Keywords Animals; *Cognition; Female; Goals; Learning; Macaca mulatta/*psychology; Male; *Mathematics; Pan troglodytes/*psychology; Task Performance and Analysis
Abstract Chimpanzees (Pan troglodytes) and rhesus macaques (Macaca mulatta) selected either Arabic numerals or colored squares on a computer monitor in a learned sequence. On shift trials, the locations of 2 stimuli were interchanged at some point. More errors were made when this interchange occurred for the next 2 stimuli to be selected than when the interchange was for stimuli later in the sequence. On mask trials, all remaining stimuli were occluded after the 1st selection. Performance exceeded chance levels for only 1 selection after these masks were applied. There was no difference in performance for either stimulus type (numerals or colors). The data indicated that the animals planned only the next selection during these computerized tasks as opposed to planning the entire response sequence.
Address Language Research Center, Georgia State University, Atlanta 30303, USA. mjberan@yahoo.com
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0097-7403 ISBN Medium
Area Expedition Conference
Notes PMID:15279511 Approved no
Call Number Equine Behaviour @ team @ Serial 2767
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Author Cerutti, D.T.; Staddon, J.E.R.
Title Immediacy versus anticipated delay in the time-left experiment: a test of the cognitive hypothesis Type Journal Article
Year 2004 Publication Journal of Experimental Psychology. Animal Behavior Processes Abbreviated Journal J Exp Psychol Anim Behav Process
Volume 30 Issue 1 Pages 45-57
Keywords Animals; Choice Behavior/*physiology; Cognition/*physiology; Columbidae; Male; Models, Psychological; Psychological Theory; *Reinforcement (Psychology); *Reinforcement Schedule; Time Perception/*physiology
Abstract In the time-left experiment (J. Gibbon & R. M. Church, 1981), animals are said to compare an expectation of a fixed delay to food, for one choice, with a decreasing delay expectation for the other, mentally representing both upcoming time to food and the difference between current time and upcoming time (the cognitive hypothesis). The results of 2 experiments support a simpler view: that animals choose according to the immediacies of reinforcement for each response at a time signaled by available time markers (the temporal control hypothesis). It is not necessary to assume that animals can either represent or subtract representations of times to food to explain the results of the time-left experiment.
Address Department of Psychological and Brain Sciences, Duke University, Durham, NC 27708-1050, USA. cerutti@psych.duke.edu
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Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
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ISSN (up) 0097-7403 ISBN Medium
Area Expedition Conference
Notes PMID:14709114 Approved no
Call Number Equine Behaviour @ team @ Serial 2768
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Author Nicol, C.J.; Yoon, M.; Ward, J.M.; Yamashita, M.; Fukamachi, K.; Peters, J.M.; Gonzalez, F.J.
Title PPARgamma influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis Type Journal Article
Year 2004 Publication Carcinogenesis Abbreviated Journal Carcinogenesis
Volume 25 Issue 9 Pages 1747-1755
Keywords 9,10-Dimethyl-1,2-benzanthracene/*toxicity; Animals; DNA Primers/chemistry; Disease Susceptibility; Female; Heterozygote; Humans; Mammary Neoplasms, Experimental/chemically induced/*pathology; Mice; Ovarian Neoplasms/chemically induced/*pathology; RNA, Messenger/genetics/metabolism; Receptors, Cytoplasmic and Nuclear/genetics/*physiology; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms/chemically induced/*pathology; Survival Rate; Transcription Factors/genetics/*physiology; Zinc Fingers
Abstract Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily, plays a role in adipocyte differentiation, type II diabetes, macrophage response to inflammation and is suggested to influence carcinogen-induced colon cancer. Studies done in vitro and in vivo also revealed that PPARgamma ligands might promote differentiation and/or regression of mammary tumors. To directly evaluate the role of PPARgamma in mammary carcinogenesis, PPARgamma wild-type (+/+) or heterozygous (+/-) mice were administered 1 mg 7,12-dimethylbenz[a]anthracene (DMBA) by gavage once a week for 6 weeks and followed for a total of 25 weeks. Compared with congenic PPARgamma(+/+) littermate controls, PPARgamma(+/-) mice had early evidence for increased susceptibility to DMBA-mediated carcinogenesis based on a 1.6-fold increase in the percentage of mice with skin papillomas, as well as a 1.7-fold increase in the numbers of skin papillomas per mouse (P < 0.05). Similarly, PPARgamma(+/-) mice also had a 1.5-fold decreased survival rate (P = 0.059), and a 1.7-fold increased incidence of total tumors per mouse (P < 0.01). Moreover, PPARgamma(+/-) mice had an almost 3-fold increase in mammary adenocarcinomas (P < 0.05), an over 3-fold increase in ovarian granulosa cell carcinomas (P < 0.05), an over 3-fold increase in malignant tumors (P < 0.02) and a 4.6-fold increase in metastatic incidence. These results are the first to demonstrate an increased susceptibility in vivo of PPARgamma haploinsufficiency to DMBA-mediated carcinogenesis and suggest that PPARgamma may act as a tumor modifier of skin, ovarian and breast cancers. The data also support evidence suggesting a beneficial role for PPARgamma-specific ligands in the chemoprevention of mammary, ovarian and skin carcinogenesis.
Address Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
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Series Editor Series Title Abbreviated Series Title
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ISSN (up) 0143-3334 ISBN Medium
Area Expedition Conference
Notes PMID:15073042 Approved no
Call Number refbase @ user @ Serial 76
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Author Dauphin, G.; Zientara, S.; Zeller, H.; Murgue, B.
Title West Nile: worldwide current situation in animals and humans Type Journal Article
Year 2004 Publication Comparative Immunology, Microbiology and Infectious Diseases Abbreviated Journal Comp Immunol Microbiol Infect Dis
Volume 27 Issue 5 Pages 343-355
Keywords Americas/epidemiology; Animals; Birds/virology; Culex/*virology; *Disease Outbreaks; Disease Reservoirs; Europe/epidemiology; Horses/virology; Humans; Insect Vectors/*virology; Middle East/epidemiology; West Nile Fever/*epidemiology/*veterinary/virology; West Nile virus/*growth & development
Abstract West Nile (WN) virus is a mosquito-borne flavivirus that is native to Africa, Europe, and Western Asia. It mainly circulates among birds, but can infect many species of mammals, as well as amphibians and reptiles. Epidemics can occur in rural as well as urban areas. Transmission of WN virus, sometimes involving significant mortality in humans and horses, has been documented at erratic intervals in many countries, but never in the New World until it appeared in New York City in 1999. During the next four summers it spread with incredible speed to large portions of 46 US states, and to Canada, Mexico, Central America and the Caribbean. In many respects, WN virus is an outstanding example of a zoonotic pathogen that has leaped geographical barriers and can cause severe disease in human and equine. In Europe, in the past two decades there have been a number of significant outbreaks in several countries. However, very little is known of the ecology and natural history of WN virus transmission in Europe and most WN outbreaks in humans and animals remain unpredictable and difficult to control.
Address AFSSA Alfort, UMR1161 (INRA-AFSSA-ENVA), 22 rue Pierre Curie, BP 63, 94703 Maisons-Alfort Cedex, France
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0147-9571 ISBN Medium
Area Expedition Conference
Notes PMID:15225984 Approved no
Call Number Equine Behaviour @ team @ Serial 2635
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Author Nelson, D.M.; Gardner, I.A.; Chiles, R.F.; Balasuriya, U.B.; Eldridge, B.F.; Scott, T.W.; Reisen, W.K.; James Maclachlan, N.
Title Prevalence of antibodies against Saint Louis encephalitis and Jamestown Canyon viruses in California horses Type Journal Article
Year 2004 Publication Comparative Immunology, Microbiology and Infectious Diseases Abbreviated Journal Comp Immunol Microbiol Infect Dis
Volume 27 Issue 3 Pages 209-215
Keywords Animals; Antibodies, Viral/*blood; California/epidemiology; Encephalitis Virus, California/*immunology/isolation & purification; Encephalitis Virus, St. Louis/*immunology/isolation & purification; Encephalitis, St. Louis/epidemiology/immunology/*veterinary/virology; Female; Horse Diseases/epidemiology/immunology/*virology; Horses; Logistic Models; Male; Neutralization Tests/veterinary; Polyomavirus Infections/epidemiology/immunology/*veterinary/virology; Questionnaires; Seroepidemiologic Studies; Tumor Virus Infections/epidemiology/immunology/*veterinary/virology
Abstract Jamestown Canyon (JC) and Saint Louis encephalitis (SLE) viruses are mosquito-transmitted viruses that have long been present in California. The objective of this study was to determine the seroprevalence of these two viruses in horses prior to the introduction of West Nile (WN) virus. Approximately 15% of serum samples collected in 1998 from 425 horses on 44 equine operations horses throughout California had serum antibodies to JC virus, whereas antibodies were not detected to SLE virus. The results indicate that horses in California were commonly infected prior to 1998 with mosquito-transmitted Bunyaviruses that are identical or closely related to JC virus, but not with SLE virus. The different seroprevalence of SLE and JC viruses in horses likely reflects the unique ecology of each virus, and it is predicted that WN virus will have a wider distribution in California than closely related SLE virus.
Address Animal and Plant Health Inspection Service, Veterinary Services, U.S. Department of Agriculture, California and Nevada Area Office, 9850 Micron Avenue, Suite E, Sacramento, CA 95827, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0147-9571 ISBN Medium
Area Expedition Conference
Notes PMID:15001316 Approved no
Call Number Equine Behaviour @ team @ Serial 2637
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Author Pickens, C.L.; Holland, P.C.
Title Conditioning and cognition Type Journal Article
Year 2004 Publication Neuroscience and Biobehavioral Reviews Abbreviated Journal Neurosci Biobehav Rev
Volume 28 Issue 7 Pages 651-661
Keywords Animals; Association Learning/physiology; Cognition/*physiology; Conditioning (Psychology)/*physiology; Discrimination Learning/physiology; Humans; Memory; Models, Psychological; Reinforcement (Psychology); Visual Perception/physiology
Abstract Animals' abilities to use internal representations of absent objects to guide adaptive behavior and acquire new information, and to represent multiple spatial, temporal, and object properties of complex events and event sequences, may underlie many aspects of human perception, memory, and symbolic thought. In this review, two classes of simple associative learning tasks that address these core cognitive capacities are discussed. The first set, including reinforcer revaluation and mediated learning procedures, address the power of Pavlovian conditioned stimuli to gain access, through learning, to representations of upcoming events. The second set of investigations concern the construction of complex stimulus representations, as illustrated in studies of contextual learning, the conjunction of explicit stimulus elements in configural learning procedures, and recent studies of episodic-like memory. The importance of identifying both cognitive process and brain system bases of performance in animal models is emphasized.
Address Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
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Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0149-7634 ISBN Medium
Area Expedition Conference
Notes PMID:15555675 Approved no
Call Number Equine Behaviour @ team @ Serial 2803
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Author Sarter, M.
Title Animal cognition: defining the issues Type Journal Article
Year 2004 Publication Neuroscience and Biobehavioral Reviews Abbreviated Journal Neurosci Biobehav Rev
Volume 28 Issue 7 Pages 645-650
Keywords Animals; Behavior, Animal/*physiology; Cognition/*physiology; Humans; *Models, Animal; Psychopharmacology/methods; Reproducibility of Results
Abstract The assessment of cognitive functions in rodents represents a critical experimental variable in many research fields, ranging from the basic cognitive neurosciences to psychopharmacology and neurotoxicology. The increasing use of animal behavioral tests as 'assays' for the assessment of effects on learning and memory has resulted in a considerable heterogeneity of data, particularly in the field of behavioral and psycho pharmacology. The limited predictive validity of changes in behavioral performance observed in standard animal tests of learning and memory indicates that a renewed effort to scrutinize the validity of these tests is warranted. In humans, levels of processing (effortful vs. automatic) and categories of information (procedural vs. episodic/declarative) are important variables of cognitive operations. The design of tasks that assess the recall of 'episodic' or 'declarative' information appears to represent a particular challenge for research using laboratory rodents. For example, the hypothesis that changes in inspection time for a previously encountered place or object are based on the recall of declarative/episodic information requires substantiation. In order to generalize findings on the effects of neuronal or pharmacological manipulations on learning and memory, obtained from one species and one task, to other species and other tasks, the mediating role of important sets of variables which influence learning and memory (e.g. attentional, affective) needs to be determined. Similar to the view that a neuronal manipulation (e.g. a lesion) represents a theory of the condition modeled (e.g. a degenerative disorder), an animal behavioral task represents a theory of the behavioral/cognitive process of interest. Therefore, the test of hypotheses regarding the validity of procedures used to assess cognitive functions in animals is an inherent part of the research process.
Address Department of Psychology, University of Michigan, 4032 East Hall, 525 E. University Avenue, Ann Arbor, MI 48109-1109, USA. msarter@umich.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) 0149-7634 ISBN Medium
Area Expedition Conference
Notes PMID:15555674 Approved no
Call Number Equine Behaviour @ team @ Serial 2804
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Author Quaranta, A.; Siniscalchi, M.; Frate, A.; Vallortigara, G.
Title Paw preference in dogs: relations between lateralised behaviour and immunity Type Journal Article
Year 2004 Publication Behavioural Brain Research Abbreviated Journal
Volume 153 Issue 2 Pages 521-525
Keywords Paw preference; Lateralisation; Immunity; Dog
Abstract Paw use in a task consisting of the removal of a piece of adhesive paper from the snout was investigated in 80 mongrel and pure-bred domestic dogs (Canis familiaris). Population lateralisation was observed, but in opposite directions in the two sexes (animals were not desexed): males preferentially used their left paw, females their right paw. The relationship between immune function and paw preference was then investigated. Some immune parameters (total number of white blood cells including lymphocytes, granulocytes and monocytes; leukocyte formula; total proteins; &#947;-globulins) were investigated in a sample of left-pawed (n=6), right-pawed (n=6) and ambidextrous (n=6) dogs. The results showed that the percentage of lymphocytes was higher in left-pawed than in right-pawed and ambidextrous dogs, whereas granulocytes percentage was lower in left-pawed than in right-pawed and ambidextrous dogs. Moreover, total number of lymphocytes cells was higher in left-pawed than in right-pawed and ambidextrous dogs, whereas the number of &#947;-globulins was lower in left-pawed than in right-pawed and ambidextrous dogs. These findings represent the first evidence that brain asymmetry modulates immune responses in dogs.
Address
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ISSN (up) 0166-4328 ISBN Medium
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Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5783
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