Records |
Author |
Gulotta, M.; Rogatsky, E.; Callender, R.H.; Dyer, R.B. |
Title |
Primary folding dynamics of sperm whale apomyoglobin: core formation |
Type |
Journal Article |
Year |
2003 |
Publication |
Biophysical Journal |
Abbreviated Journal |
Biophys J |
Volume |
84 |
Issue |
3 |
Pages |
1909-1918 |
Keywords |
Animals; Apoproteins/*chemistry; Crystallography/*methods; Horses; Myocardium/chemistry; Myoglobin/*chemistry; Protein Conformation; *Protein Folding; Species Specificity; Structure-Activity Relationship; Temperature; Whales |
Abstract |
The structure, thermodynamics, and kinetics of heat-induced unfolding of sperm whale apomyoglobin core formation have been studied. The most rudimentary core is formed at pH(*) 3.0 and up to 60 mM NaCl. Steady state for ultraviolet circular dichroism and fluorescence melting studies indicate that the core in this acid-destabilized state consists of a heterogeneous composition of structures of approximately 26 residues, two-thirds of the number involved for horse heart apomyoglobin under these conditions. Fluorescence temperature-jump relaxation studies show that there is only one process involved in Trp burial. This occurs in 20 micro s for a 7 degrees jump to 52 degrees C, which is close to the limits placed by diffusion on folding reactions. However, infrared temperature jump studies monitoring native helix burial are biexponential with times of 5 micro s and 56 micro s for a similar temperature jump. Both fluorescence and infrared fast phases are energetically favorable but the slow infrared absorbance phase is highly temperature-dependent, indicating a substantial enthalpic barrier for this process. The kinetics are best understood by a multiple-pathway kinetics model. The rapid phases likely represent direct burial of one or both of the Trp residues and parts of the G- and H-helices. We attribute the slow phase to burial and subsequent rearrangement of a misformed core or to a collapse having a high energy barrier wherein both Trps are solvent-exposed. |
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Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA. gulotta@aecom.yu.edu |
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0006-3495 |
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PMID:12609893 |
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Equine Behaviour @ team @ |
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3783 |
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Day, R.L.; Coe, R.L.; Kendal, J.R.; Laland, K.N. |
Title |
Neophilia, innovation and social learning: a study of intergeneric differences in callitrichid monkeys |
Type |
Journal Article |
Year |
2003 |
Publication |
Animal Behaviour |
Abbreviated Journal |
Anim. Behav. |
Volume |
65 |
Issue |
3 |
Pages |
559-571 |
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Abstract |
In a comparative study of neophilia, innovation and social attentiveness we exposed individuals in seven callitrichid species, from three genera, to novel extractive foraging tasks. The results revealed consistently shorter response latencies, higher levels of successful and unsuccessful manipulation, and greater attentiveness to the task and to conspecifics inLeontopithecus (lion tamarins) than in both Saguinus (tamarins) and Callithrix (marmosets). This is consistent with the hypothesis that species dependent upon manipulative and explorative foraging tend to be less neophobic and more innovative than other species. Furthermore, Callithrix appeared to be less neophobic than Saguinus; ifCallithrix is regarded as the greater specialist, this result is inconsistent with the hypothesis that neophobia is associated with foraging specialization. We consider the relevance of our findings to taxonomic relationships, and to technical and Machiavellian intelligence hypotheses and discuss the implications for captive breeding and reintroduction strategies.Copyright 2003 Published by Elsevier Science Ltd on behalf of The Association for the Study of Animal Behaviour. |
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0003-3472 |
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Equine Behaviour @ team @ |
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6035 |
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Reader, S.M.; Kendal, J.R.; Laland, K.N. |
Title |
Social learning of foraging sites and escape routes in wild Trinidadian guppies |
Type |
Journal Article |
Year |
2003 |
Publication |
Animal Behaviour |
Abbreviated Journal |
Anim. Behav. |
Volume |
66 |
Issue |
4 |
Pages |
729-739 |
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Abstract |
We describe two field experiments with wild guppies, Poecilia reticulata, in Trinidad that demonstrated that guppies can acquire foraging and predator escape-response information from conspecifics. In the foraging experiment, subjects were presented with two distinctly marked feeders in their home rivers. One feeder contained a conspecific shoal in a transparent container. Guppies preferred to enter the feeder containing this artificial shoal over the other feeder. In a test phase, the artificial shoal was removed and the feeders replaced at the testing site after a 5-min delay. More guppies entered the feeder that had contained the artificial shoal over the other feeder, a difference that can be explained only by the fish learning the characteristics or location of the feeder during the training phase. We suggest that subjects acquired a foraging patch preference through a propensity to approach feeding conspecifics, a local enhancement process. In the predator escape-response experiment, naive 'observer' guppies could avoid an approaching trawl net by escaping through either a hole to which 'demonstrator' guppies had been trained or through an alternative hole. When the demonstrators were present, the naive observers escaped more often and more rapidly by the demonstrated route than the alternative route. When the demonstrators were removed, observers maintained a route preference according to the training of their demonstrators, which suggests that the observers had learned an escape route through following or observing their more knowledgeable conspecifics. Thus, both experiments reveal that guppies can socially learn in the wild. Copyright 2003 Published by Elsevier Ltd on behalf of The Association for the Study of Animal Behaviour. |
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0003-3472 |
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Equine Behaviour @ team @ |
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6163 |
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Author |
Dubois, F.; Giraldeau, L.-A. |
Title |
The forager's dilemma: food sharing and food defense as risk-sensitive foraging options |
Type |
Journal Article |
Year |
2003 |
Publication |
The American Naturalist |
Abbreviated Journal |
Am Nat |
Volume |
162 |
Issue |
6 |
Pages |
768-779 |
Keywords |
Animals; Competitive Behavior/*physiology; *Environment; Feeding Behavior/*physiology; *Game Theory; *Models, Biological; Population Density; Population Dynamics |
Abstract |
Although many variants of the hawk-dove game predict the frequency at which group foraging animals should compete aggressively, none of them can explain why a large number of group foraging animals share food clumps without any overt aggression. One reason for this shortcoming is that hawk-dove games typically consider only a single contest, while most group foraging situations involve opponents that interact repeatedly over discovered food clumps. The present iterated hawk-dove game predicts that in situations that are analogous to a prisoner's dilemma, animals should share the resources without aggression, provided that the number of simultaneously available food clumps is sufficiently large and the number of competitors is relatively small. However, given that the expected gain of an aggressive animal is more variable than the gain expected by nonaggressive individuals, the predicted effect of the number of food items in a clump-clump richness-depends on whether only the mean or both the mean and variability associated with payoffs are considered. More precisely, the deterministic game predicts that aggression should increase with clump richness, whereas the stochastic risk-sensitive game predicts that the frequency of encounters resulting in aggression should peak at intermediate clump richnesses or decrease with increasing clump richness if animals show sensitivity to the variance or coefficient of variation, respectively. |
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Departement des Sciences Biologiques, Universite du Quebec a Montreal, Case postale 8888, Succursale Centre-Ville, Montreal, Quebec H3C 3P8, Canada. fdubois@u-bourgogne.fr |
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0003-0147 |
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PMID:14737714 |
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2132 |
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Spadavecchia, C.; Arendt-Nielsen, L.; Andersen, O.K.; Spadavecchia, L.; Doherr, M.; Schatzmann, U. |
Title |
Comparison of nociceptive withdrawal reflexes and recruitment curves between the forelimbs and hind limbs in conscious horses |
Type |
Journal Article |
Year |
2003 |
Publication |
American journal of veterinary research |
Abbreviated Journal |
Am J Vet Res |
Volume |
64 |
Issue |
6 |
Pages |
700-707 |
Keywords |
Animals; Consciousness; Female; Forelimb/*physiology; Hindlimb/*physiology; Horses/*physiology; Male; Nociceptors/physiology; Pain/*physiopathology/*veterinary; Pain Threshold/physiology; Recruitment, Neurophysiological/physiology; Reflex/*physiology |
Abstract |
OBJECTIVE: To compare nociceptive withdrawal reflexes (NWRs) evoked from the distal aspect of the left forelimb and hind limb in conscious standing horses and to investigate NWR recruitment for graded electrical stimulation intensities. ANIMALS: 20 adult horses. PROCEDURE: Surface electromyographic (EMG) activity evoked by transcutaneous electrical stimulation of the digital palmar (or plantar) nerve was recorded from the common digital extensor and cranial tibial muscles. Stimuli consisted of 25-millisecond train-of-5 constant current pulses. Current intensity was gradually increased until NWR threshold intensity was reached. The EMG signal was analyzed for quantification of the NWR. Behavioral responses accompanying the reflex were scored (scale, 0 to 5). The NWR recruitment curves were determined at 0.9, 1.1, 1.2, and 1.3 times the NWR threshold intensity. RESULTS: The NWR threshold was significantly higher for the hind limb (median value, 6.6 mA; range, 3 to 10 mA) than the forelimb (median, 3 mA; range, 1.7 to 5.5 mA). The NWR of the hind limb had a significantly longer latency (median, 122.8 milliseconds; range, 106 to 172 milliseconds), compared with the forelimb (median, 98 milliseconds; range, 86 to 137 milliseconds), and it was associated with significantly stronger behavioral reactions. Gradual increase of NWR amplitude was evident at increasing stimulation intensities and supported by the behavioral observations. CONCLUSIONS AND CLINICAL RELEVANCE: We documented NWRs evoked from the forelimb and hind limb and their recruitment with stimuli of increasing intensity in horses. These results provide a basis for use of NWRs in studies on nociceptive modulation in horses. |
Address |
Department of Clinical Veterinary Sciences, University of Berne, Switzerland |
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0002-9645 |
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PMID:12828255 |
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refbase @ user @ |
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93 |
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Herholz, C.P.; Gerber, V.; Tschudi, P.; Straub, R.; Imhof, A.; Busato, A. |
Title |
Use of volumetric capnography to identify pulmonary dysfunction in horses with and without clinically apparent recurrent airway obstruction |
Type |
Journal Article |
Year |
2003 |
Publication |
American Journal of Veterinary Research |
Abbreviated Journal |
Am J Vet Res |
Volume |
64 |
Issue |
3 |
Pages |
338-345 |
Keywords |
Aging; Airway Obstruction/*complications/diagnosis/*veterinary; Animals; Capnography/*methods/*veterinary; Female; Horse Diseases/*diagnosis; Horses; Lung Diseases/complications/*diagnosis/*veterinary; Male; Predictive Value of Tests |
Abstract |
OBJECTIVE: To investigate whether volumetric capnography indices could be used to differentiate between horses without recurrent airway obstruction (RAO) and horses with RAO that were in clinical remission or that had clinically apparent RAO. ANIMALS: 70 adult Swiss Warmblood horses (20 used for pleasure riding and 50 used for dressage or show jumping). PROCEDURE: Horses were allocated to 4 groups on the basis of history, clinical signs, results of endoscopy, and cytologic findings (group 1, 21 healthy horses; group 2, 22 horses with RAO that were in remission; group 3, 16 horses with mild RAO; group 4, 11 horses with exacerbated RAO). Expiratory volume and CO2 curves were recorded by use of a computerized ultrasonic spirometer. Volumetric capnograms were plotted, and derived indices were calculated. RESULTS: Dead-space volume (VD) was calculated by use of the Bohr equation (VD(Bohr)) and for physiologic VD (VD(phys)). Ratios for VD(Bohr) to expiratory tidal volume (VT) and VD(phys) to V(T) as well as an index of effective CO2 elimination were significantly different among groups of horses. Age and use of the horses also significantly affected volumetric capnography indices. CONCLUSIONS AND CLINICAL RELEVANCE: Ratios of VD(Bohr) to VT and VD(phys) to VT as well as an index of effective CO2 elimination were sufficiently sensitive measures to distinguish between healthy horses and horses with RAO in remission. To optimize the ability of volumetric capnography indices to differentiate among horses in heterogeneous populations, it is important to account for effects of age and specific use of the horses. |
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Department of Equine Internal Medicine, Faculty of Veterinary Medicine, University of Berne, Langgasstr 124, CH-3012 Berne, Switzerland |
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0002-9645 |
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PMID:12661875 |
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Equine Behaviour @ team @ |
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3724 |
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Author |
Sondergaard, E.; Halekoh, U. |
Title |
Young horses' reactions to humans in relation to handling and social environment |
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Journal Article |
Year |
2003 |
Publication |
Applied Animal Behaviour Science |
Abbreviated Journal |
Appl. Anim. Behav. Sci. |
Volume |
84 |
Issue |
4 |
Pages |
265-280 |
Keywords |
Horses; Human-animal relationship; Social environment; Handling |
Abstract |
Forty Danish warmblood colts in two replicates were used to investigate the effect of housing and handling in the rearing period on the reactions to humans. The horses entered the experiment after weaning and were housed either individually (n=16) or in groups of three (n=24). Half of the horses from each housing group were handled three times per week for a period of 10 min. Approach tests were performed in the home environment when the horses were 6, 9, 12, 18, 21, and 24 months old, and an Arena and Human Encounter test was performed in a novel environment when the horses were 12 and 24 months old, respectively. In the home environment, single-housed horses approached sooner and were more easily approached by a human than group-housed horses where no effect of handling was observed. Horses approached sooner and were more easily approached with increasing age. In the Arena and Human Encounter test, single-housed horses expressed less restless behaviour, more explorative behaviour, and less vocalisation than group-housed horses. Handled horses showed lower increase in heart rate during the test than non-handled horses. There was no difference between the number of times single or group-housed horses touched an unfamiliar person in the Arena and Human Encounter test but handled horses approached sooner than non-handled horses. It is concluded that the social environment affected the way horses reacted to humans when tested in the home environment but not in a novel environment. In contrast, handling affected the reactions to humans when tested in the novel environment but not in the home environment. However, handled horses also reacted less to the novel environment in general, thus indicating that handling is a mean of avoiding potential dangerous situations. |
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308 |
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Visser, E.K.; Van Reenen, C.G.; Engel, B.; Schilder, M.B.H.; Barneveld, A.; Blokhuis, H.J. |
Title |
The association between performance in show-jumping and personality traits earlier in life |
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Journal Article |
Year |
2003 |
Publication |
Applied Animal Behaviour Science |
Abbreviated Journal |
Appl. Anim. Behav. Sci. |
Volume |
82 |
Issue |
4 |
Pages |
279-295 |
Keywords |
Personality; Performance; Horses; Prediction; Individual differences; Behavioural tests |
Abstract |
For a horse to succeed in a show-jumping career, the individual has to possess both excellent physical abilities as well as a suitable personality to perform under challenging conditions. Forty-one Dutch Warmblood horses were used to develop personality tests and correlations between test variables and early training performances in jumping were studied. In behavioural tests, during the first 2 years of the horses' lives, personality aspects like emotionality, reactivity to human and learning abilities were quantified. At the age of 3, horses were broken and received early training in show-jumping. The inter-relationship between several performance variables measured during this early training phase were studied using principal component analysis (PCA). Variables measured in the different personality tests (novel-object test, handling test, avoidance-learning test and a reward-learning test) showed no correlations, suggesting that these tests all triggered different aspects of a horse's personality. This study indicates that it is possible to predict a substantial part of the show-jumping performance of an individual horse later in life by personality traits earlier in life. |
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326 |
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Clotfelter, E.D.; Paolino, A.D. |
Title |
Bystanders to contests between conspecifics are primed for increased aggression in male fighting fish |
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Journal Article |
Year |
2003 |
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Animal Behaviour. |
Abbreviated Journal |
Anim. Behav. |
Volume |
66 |
Issue |
2 |
Pages |
343-347 |
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We performed two experiments in which we allowed a male fighting fish, Betta splendens, designated a bystander, to observe aggressive contests between pairs of male conspecifics. Another male (naive male) observed an empty tank or two nonaggressive males, depending on the experiment. Immediately after these observation periods, we allowed the bystander and naive male to interact in a neutral area. In both experiments, bystander males were dominant over naive males in a significant number of the encounters. Bystander males performed significantly more aggressive behaviours (displays, chases and bites) than did naive males. Differences in dominance were not due to chance differences in body size. These findings demonstrate that exposure to aggression between conspecifics increases aggressive motivation in bystander male fighting fish. We discuss briefly the implications of such social experience on the formation of dominance hierarchies. Copyright 2003 Published by Elsevier Ltd on behalf of The Association for the Study of Animal Behaviour. |
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Cooper, J.J.; Ashton, C.; Bishop, S.; West, R.; Mills, D.S.; Young, R.J. |
Title |
Clever hounds: social cognition in the domestic dog (Canis familiaris) |
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Journal Article |
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2003 |
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Applied Animal Behaviour Science |
Abbreviated Journal |
Appl. Anim. Behav. Sci. |
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81 |
Issue |
3 |
Pages |
229-244 |
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Domestic dog; Canine; Social cognition; Counting; Theory of mind; Perspective taking |
Abstract |
This paper reviews the reasons why domestic dogs make good models to investigate cognitive processes related to social living and describes experimental approaches that can be adopted to investigate such processes in dogs. Domestic dogs are suitable models for investigating social cognition skills for three broad reasons. First, dogs originated from wolves, social animals that engage in a number of co-operative behaviours, such as hunting and that may have evolved cognitive abilities that help them predict and interpret the actions of other animals. Second, during domestication dogs are likely to have been selected for mental adaptations for their roles in human society such as herding or companionship. Third, domestic dogs live in a human world and “enculturation” may facilitate the development of relevant mental skills in dogs. Studies of social cognition in animals commonly use experimental paradigms originally developed for pre-verbal human infants. Preferential gaze, for example, can be used as a measure of attention or “surprise” in studies using expectancy violation. This approach has been used to demonstrate simple numerical competence in dogs. Dogs also readily use both conspecific and human social signals (e.g. looking or pointing) as information sources to locate hidden rewards such as food or favourite toys. Such abilities make dogs particularly good models for investigating perspective-taking tasks, where animals are required to discriminate between apparently knowledgeable and apparently ignorant informants. |
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