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Author Milo, R.; Itzkovitz, S.; Kashtan, N.; Levitt, R.; Alon, U.
Title Response to Comment on “Network Motifs: Simple Building Blocks of Complex Networks” and “Superfamilies of Evolved and Designed Networks” Type Journal Article
Year 2004 Publication Science Abbreviated Journal Science
Volume 305 Issue 5687 Pages 1107d
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Notes 10.1126/science.1100519 Approved no
Call Number Equine Behaviour @ team @ Serial 5031
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Author Milo, R.; Itzkovitz, S.; Kashtan, N.; Levitt, R.; Shen-Orr, S.; Ayzenshtat, I.; Sheffer, M.; Alon, U.
Title Superfamilies of Evolved and Designed Networks Type Journal Article
Year 2004 Publication Science Abbreviated Journal Science
Volume 303 Issue 5663 Pages 1538-1542
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Abstract Complex biological, technological, and sociological networks can be of very different sizes and connectivities, making it difficult to compare their structures. Here we present an approach to systematically study similarity in the local structure of networks, based on the significance profile (SP) of small subgraphs in the network compared to randomized networks. We find several superfamilies of previously unrelated networks with very similar SPs. One superfamily, including transcription networks of microorganisms, represents “rate-limited” information-processing networks strongly constrained by the response time of their components. A distinct superfamily includes protein signaling, developmental genetic networks, and neuronal wiring. Additional superfamilies include power grids, protein-structure networks and geometric networks, World Wide Web links and social networks, and word-adjacency networks from different languages.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN (up) ISBN Medium
Area Expedition Conference
Notes 10.1126/science.1089167 Approved no
Call Number Equine Behaviour @ team @ Serial 5033
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