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Author | Noti, M.; Sidler, D.; Brunner, T. | ||||
Title | Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? | Type | Journal Article | ||
Year | 2009 | Publication | Seminars in Immunopathology | Abbreviated Journal | Semin. Immunopathol. |
Volume | 31 | Issue | 2 | Pages | 237-248 |
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Abstract | Glucocorticoids (GC) are lipophilic hormones commonly used as therapeutics in acute and chronic inflammatory disorders such as inflammatory bowel disease due to their attributed anti-inflammatory and immunosuppressive actions. Although the adrenal glands are the major source of endogenous GC, there is increasing evidence for the production of extra-adrenal GC in the brain, thymus, skin, vasculature, and the intestine. However, the physiological relevance of extra-adrenal-produced GC remains still ambiguous. Therefore, this review attracts attention to discuss possible biological benefits of extra-adrenal-synthesized GC, especially focusing on the impact of locally synthesized GC in the regulation of intestinal immune responses. | ||||
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Language | Summary Language | Original Title | |||
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ISSN | 1863-2300 | ISBN ![]() |
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Area | Expedition | Conference | |||
Notes | Approved | no | |||
Call Number | Equine Behaviour @ team @ Noti2009 | Serial | 6001 | ||
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