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	Author	Cheung, C.; Akiyama, T.E.; Ward, J.M.; Nicol, C.J.; Feigenbaum, L.; Vinson, C.; Gonzalez, F.J.
	Title	Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha			Type	Journal Article
	Year	2004	Publication	Cancer research	Abbreviated Journal	Cancer Res
	Volume	64	Issue	11	Pages	3849-3854
	Keywords	Animals; Anticholesteremic Agents/pharmacology; Carcinogens/pharmacology; Cell Division; DNA Replication/drug effects; Fatty Acids/metabolism; Hepatocytes/cytology/drug effects/metabolism/physiology; Humans; Mice; Mice, Transgenic; Oxidation-Reduction; Peroxisome Proliferators/pharmacology; Pyrimidines/pharmacology; Receptors, Cytoplasmic and Nuclear/genetics/physiology; Species Specificity; Transcription Factors/genetics/*physiology
	Abstract	Lipid-lowering fibrate drugs function as agonists for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). Sustained activation of PPARalpha leads to the development of liver tumors in rats and mice. However, humans appear to be resistant to the induction of peroxisome proliferation and the development of liver cancer by fibrate drugs. The molecular basis of this species difference is not known. To examine the mechanism determining species differences in peroxisome proliferator response between mice and humans, a PPARalpha-humanized mouse line was generated in which the human PPARalpha was expressed in liver under control of the tetracycline responsive regulatory system. The PPARalpha-humanized and wild-type mice responded to treatment with the potent PPARalpha ligand Wy-14643 as revealed by induction of genes encoding peroxisomal and mitochondrial fatty acid metabolizing enzymes and resultant decrease of serum triglycerides. However, surprisingly, only the wild-type mice and not the PPARalpha-humanized mice exhibited hepatocellular proliferation as revealed by elevation of cell cycle control genes, increased incorporation of 5-bromo-2'-deoxyuridine into hepatocyte nuclei, and hepatomegaly. These studies establish that following ligand activation, the PPARalpha-mediated pathways controlling lipid metabolism are independent from those controlling the cell proliferation pathways. These findings also suggest that structural differences between human and mouse PPARalpha are responsible for the differential susceptibility to the development of hepatocarcinomas observed after treatment with fibrates. The PPARalpha-humanized mice should serve as models for use in drug development and human risk assessment and to determine the mechanism of hepatocarcinogenesis of peroxisome proliferators.
	Address	Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0008-5472	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:15172993			Approved	no
	Call Number	refbase @ user @			Serial	74
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	Author	Alexander, F.; Collett, R.A.
	Title	Proceedings: Some observations on the pharmacokinetics of trimethoprim in the horse			Type	Journal Article
	Year	1974	Publication	British journal of pharmacology	Abbreviated Journal	Br J Pharmacol
	Volume	52	Issue	1	Pages	142p
	Keywords	Animals; Half-Life; Horses/metabolism; Kinetics; Trimethoprim/metabolism
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0007-1188	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:4451793			Approved	no
	Call Number	refbase @ user @			Serial	112
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	Author	Alexander, F.; Collett, R.A.
	Title	Pethidine in the horse			Type	Journal Article
	Year	1974	Publication	Research in veterinary science	Abbreviated Journal	Res Vet Sci
	Volume	17	Issue	1	Pages	136-137
	Keywords	Animals; Half-Life; Horses/metabolism; Injections, Intravenous/veterinary; Male; Meperidine/administration & dosage/analysis/metabolism/pharmacology
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0034-5288	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:4421117			Approved	no
	Call Number	refbase @ user @			Serial	113
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	Author	Minero, M.; Zucca, D.; Canali, E.
	Title	A note on reaction to novel stimulus and restraint by therapeutic riding horses			Type	Journal Article
	Year	2006	Publication	Applied Animal Behaviour Science	Abbreviated Journal	Appl. Anim. Behav. Sci.
	Volume	97	Issue	2-4	Pages	335-342
	Keywords	Horse; Therapeutic riding; Behavioural indicators; Heart rate; Lymphocyte proliferation
	Abstract	Little research has been done to measure reactivity objectively in therapeutic riding horses (TRH). As individual reactivity and chronic stress could be assessed by exposing animals to acute, novel stressors, the authors of this work aimed at comparing reactions of TRHs and jumping horses (JH) to two challenges. Four TRHs and four JHs were exposed to a restraint covering their head with a hood for 1 h and to a startling stimulus (a 40 cm long, red and white synthetic holiday garland shaken with a rustling noise inside the box). Heart rate (HR) and heart rate variability (HRV) were recorded continuously and telemetrically, the reaction was video-recorded and analysed with a software for behavioural analysis. Blood samples were collected before and after each challenge to determine lymphocyte proliferation and other biochemical parameters. Horses spent most of the time immobile, during the challenges (p < 0.05). TRHs had a significantly higher average basal HR than JH (p < 0.05), probably due to their better condition. HR varied among different behaviours during the restraint (p < 0.05): the average HR during “pawing” was higher than during other behaviours (p < 0.005). A significant decrease in the proliferation of lymphocytes in samples taken after the removal of the hood (p < 0.05) was found, while the other stress related parameters did not vary significantly after the challenges. The authors conclude that TRHs did not react less than JHs to the new stimuli and this should be taken into consideration while planning their daily work and management.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	refbase @ user @			Serial	279
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	Author	Dall, Sasha R. X; Houston, Alasdair I.; McNamara, John M.
	Title	The behavioural ecology of personality: consistent individual differences from an adaptive perspective			Type	Journal Article
	Year	2004	Publication	Ecology Letters	Abbreviated Journal	Ecol. Letters
	Volume	7	Issue		Pages	734-739
	Keywords	Adaptive individual differences, behavioural ecology, behavioural syndromes, evolutionary game theory, life history strategies, personality differences, state-dependent dynamic programming
	Abstract	Individual humans, and members of diverse other species, show consistent differences in aggressiveness, shyness, sociability and activity. Such intraspecific differences in behaviour have been widely assumed to be non-adaptive variation surrounding (possibly) adaptive population-average behaviour. Nevertheless, in keeping with recent calls to apply Darwinian reasoning to ever-finer scales of biological variation, we sketch the fundamentals of an adaptive theory of consistent individual differences in behaviour. Our thesis is based on the notion that such .personality differences. can be selected for if fitness payoffs are dependent on both the frequencies with which competing strategies are played and an individual`s behavioural history. To this end, we review existing models that illustrate this and propose a game theoretic approach to analyzing personality differences that is both dynamic and state-dependent. Our motivation is to provide insights into the evolution and maintenance of an apparently common animal trait: personality, which has far reaching ecological and evolutionary implications.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	refbase @ user @			Serial	494
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	Author	Berger, J
	Title	Wild horses of the Great Basin			Type	Book Whole
	Year	1986	Publication	University of Chicago Press,	Abbreviated Journal	Univ. of Chic. Press
	Volume		Issue		Pages
	Keywords	wildlife equine behaviour ecology
	Abstract	Describes the behavior of wild horses living in the Great Basin Desert of Nevada and discusses the role of the horses in the area's ecology
	Address
	Corporate Author				Thesis
	Publisher	University of Chicago Press	Place of Publication	Chicago	Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN	0-226-04367-3	Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	refbase @ user @			Serial	659
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	Author	Peltzer, K.; Mabilu, M.G.; Mathoho, S.F.; Nekhwevha, A.P.; Sikhwivhilu, T.; Sinthumule, T.S.
	Title	Trauma history and severity of gambling involvement among horse-race gamblers in a South African gambling setting			Type	Journal Article
	Year	2006	Publication	Psychological Reports	Abbreviated Journal	Psychol Rep
	Volume	99	Issue	2	Pages	472-476
	Keywords	Adult; African Continental Ancestry Group/psychology/statistics & numerical data; Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Gambling/psychology; Humans; Life Change Events; Male; Middle Aged; Personality Inventory; Risk Factors; Social Environment; Socioeconomic Factors; South Africa; Statistics; Stress Disorders, Post-Traumatic/epidemiology/*psychology
	Abstract	The purpose of this study was to ascertain the frequency of gambling involvement and the prevalence of problem gambling among horse race gamblers and to discover whether problem gambling in this sample is associated with a history of trauma. Among a sample of 266 South African horse-race gamblers (94% men and 6% women, Mage 46.8 yr., SD = 13.9, range 18-85 years), 31.2% were classified as probable pathological gamblers and 19.9% with problem gambling. Major weekly gambling activities included racetrack betting (82%), purchase of lottery tickets or scratch tickets (35%), purchase of sports lottery tickets (23%), and using casino type games (18%). Trauma history was significantly associated with gambling severity.
	Address	Human Sciences Research Council, University of Limpopo, Pretoria, South Africa. KPeltzer@hsrc.ac.za
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0033-2941	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:17153816			Approved	no
	Call Number				Serial	1850
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	Author	Lin, Y.-L.; Moolenaar, H.; van Weeren, P.R.; van de Lest, C.H.A.
	Title	Effect of microcurrent electrical tissue stimulation on equine tenocytes in culture			Type	Journal Article
	Year	2006	Publication	American Journal of Veterinary Research	Abbreviated Journal	Am J Vet Res
	Volume	67	Issue	2	Pages	271-276
	Keywords	Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Electric Stimulation; Horses; Tendons/cytology
	Abstract	OBJECTIVE: To determine effects of microcurrent electrical tissue stimulation (METS) on equine tenocytes cultured from the superficial digital flexor tendon (SDFT). SAMPLE POPULATION: SDFTs were collected from 20 horses at slaughter. PROCEDURE: Tenocytes were isolated following outgrowth from explants and grown in 48-well plates. Four methods of delivering current to the tenocytes with a METS device were tested. Once the optimal method was selected, current consisting of 0 (negative control), 0.05, 0.1, 0.5, 1.0, or 1.5 mA was applied to cells (8 wells/current intensity) once daily for 8 minutes. Cells were treated for 1, 2, or 3 days. Cell proliferation, DNA content, protein content, and apoptosis rate were determined. RESULTS: Application of microcurrent of moderate intensity increased cell proliferation and DNA content, with greater increases with multiple versus single application. Application of microcurrent of moderate intensity once or twice increased protein content, but application 3 times decreased protein content. Application of current a single time did not significantly alter apoptosis rate; however, application twice or 3 times resulted in significant increases in apoptosis rate, and there were significant linear (second order) correlations between current intensity and apoptosis rate when current was applied twice or 3 times. CONCLUSIONS AND CLINICAL RELEVANCE: Results of the present study indicate that microcurrent affects the behavior of equine tenocytes in culture, but that effects may be negative or positive depending on current intensity and number of applications. Therefore, results are far from conclusive with respect to the suitability of using METS to promote tendon healing in horses.
	Address	Department of Equine Sciences, Faculty of Veterinary Medicine, State University of Utrecht, Utrecht, The Netherlands
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0002-9645	ISBN		Medium
	Area		Expedition		Conference
	Notes	PMID:16454632			Approved	no
	Call Number				Serial	1878
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	Author	Berger, J.
	Title	Wild Horses of the Great Basin: Social Competition and Population Size			Type	Book Whole
	Year	1986	Publication		Abbreviated Journal
	Volume		Issue		Pages
	Keywords	Wildlife Behavior Ecology
	Abstract	Editorial Reviews From Library Journal Berger begins this scholarly and absorbing treatise by discussing the natural history of the horse in general. Then, on the basis of several years of field work, he describes and details the behavior and ecology of the wild horses in the Great Basin Desert of Nevada. The purpose of the book is not, however, merely to describe natural history, but also to test quantitatively several basic ecological hypotheses. Berger has done both well, and his book will be a major source of information on North American wild horses for years to come. The book will interest specialists and graduate students primarily. It may also appeal to anyone with a strong interest in wild horses, and the remote and starkly beautiful Great Basin. Nicholas J. Volkman, Point Reyes Bird Observatory, Stinson Beach, Cal. Copyright 1986 Reed Business Information, Inc.
	Address
	Corporate Author				Thesis
	Publisher	University of Chicago Press	Place of Publication	Chicago	Editor
	Language	Englisch	Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-0226043678	Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	Equine Behaviour @ team @			Serial	2173
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	Author	VanDierendonck, M.C.
	Title	Social relationships in a group of horses without a mature stallion			Type	Manuscript
	Year	2006	Publication	The Importance of Social Relationships in Horses	Abbreviated Journal
	Volume	Chapter 4	Issue		Pages
	Keywords	Feral horses are social animals, which have to rely on survival strategies centered on the formation of cohesive social bonds within their bands. Many problems in the husbandry of social animals such as horses, are due to the fact that the limits of their adaptive abilities are exceeded. Evidence suggests that the fundamental social characteristics of domestic horses have remained relatively unchanged. The social structure, social strategies and social interactions were investigated (3 non-consecutive years, 24 hr per day for several weeks) in long term established groups of domestic horses (mares and geldings of all ages) and a few small introduced groups, kept in (semi)natural environments. The general aim was to investigate the social needs of domestic horses. The social life of domestic horses was characterised by long lasting bonds with preferred partners which were established and maintained by allogrooming, play, proximity and dominance behaviours. Bonding partners were mainly found within the same sex-age group, but adult geldings also bonded with sub-adult mares and geldings. Adult mares were clustered in a group, while the other animals formed a second group. Among the adult mares, subgroups according to reproductive state were formed. Individuals regulated their social network by interfering with interactions between other members of the herd, which in itself is complex. An intervention is a behavioural action of one animal that actively interferes with an ongoing interaction between a dyad with the apparent aim of altering that interaction. This was verified by post-hoc analyses of disturbed and undisturbed interactions. Interventions in allogrooming or play were performed significantly more often when at least one member of the initial dyad was a preferred partner of, or familiar to (within the small introduced bands) the intervener. The stronger the preferred association in allogrooming between the intervener and member(s) of the initial dyad, the higher the probability the intervener would displace one initial member and continue allogrooming with the other. Just five behaviours were extracted which reliably reflected the dominance relations among horses. Aggression with the hind quarters was used both offensively and defensively and therefore not suitable as a reliable parameter. Individual dominance relationships were related to social experience. The implications of these findings for horse husbandry were assessed. It is argued that the execution of affiliative behaviours may be rewarding in itself, and therefore always will be a highly motivated behaviour. It is shown that social positive physical interactions (allogrooming, play) with other horses is an ethological need and therefore indispensable in modern husbandry systems. Ethological needs are so important for the animal that husbandry systems that lack the possibilities to execute such behaviours will cause chronic stress. It is concluded that all horses need physical social contact, and that horses, which lack appropriate social learning experiences during ontogeny, may be hampered in their social functioning later in life. Solutions for problems, including dominance problems, in individual social housing and group housing are presented.
	Abstract	Feral horses are social animals, which have to rely on survival strategies centered on the formation of cohesive social bonds within their bands. Many problems in the husbandry of social animals such as horses, are due to the fact that the limits of their adaptive abilities are exceeded. Evidence suggests that the fundamental social characteristics of domestic horses have remained relatively unchanged. The social structure, social strategies and social interactions were investigated (3 non-consecutive years, 24 hr per day for several weeks) in long term established groups of domestic horses (mares and geldings of all ages) and a few small introduced groups, kept in (semi)natural environments. The general aim was to investigate the social needs of domestic horses. The social life of domestic horses was characterised by long lasting bonds with preferred partners which were established and maintained by allogrooming, play, proximity and dominance behaviours. Bonding partners were mainly found within the same sex-age group, but adult geldings also bonded with sub-adult mares and geldings. Adult mares were clustered in a group, while the other animals formed a second group. Among the adult mares, subgroups according to reproductive state were formed. Individuals regulated their social network by interfering with interactions between other members of the herd, which in itself is complex. An intervention is a behavioural action of one animal that actively interferes with an ongoing interaction between a dyad with the apparent aim of altering that interaction. This was verified by post-hoc analyses of disturbed and undisturbed interactions. Interventions in allogrooming or play were performed significantly more often when at least one member of the initial dyad was a preferred partner of, or familiar to (within the small introduced bands) the intervener. The stronger the preferred association in allogrooming between the intervener and member(s) of the initial dyad, the higher the probability the intervener would displace one initial member and continue allogrooming with the other. Just five behaviours were extracted which reliably reflected the dominance relations among horses. Aggression with the hind quarters was used both offensively and defensively and therefore not suitable as a reliable parameter. Individual dominance relationships were related to social experience. The implications of these findings for horse husbandry were assessed. It is argued that the execution of affiliative behaviours may be rewarding in itself, and therefore always will be a highly motivated behaviour. It is shown that social positive physical interactions (allogrooming, play) with other horses is an ethological need and therefore indispensable in modern husbandry systems. Ethological needs are so important for the animal that husbandry systems that lack the possibilities to execute such behaviours will cause chronic stress. It is concluded that all horses need physical social contact, and that horses, which lack appropriate social learning experiences during ontogeny, may be hampered in their social functioning later in life. Solutions for problems, including dominance problems, in individual social housing and group housing are presented.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication	Universiteit Utrecht	Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	Equine Behaviour @ team @			Serial	2369
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