| Records |
Author  |
Hintz, R.L. |
| Title |
Genetics of performance in the horse |
Type |
Journal Article |
| Year |
1980 |
Publication |
Journal of Animal Science |
Abbreviated Journal |
J. Anim Sci. |
| Volume |
51 |
Issue |
3 |
Pages |
582-594 |
| Keywords |
Animals; Exertion; Horses/*genetics/physiology; Sports |
| Abstract |
Criteria used to measure performance, environmental factors that influence performance and estimates of heritability are needed to estimate genetic differences. Published heritability estimates of various measures of performance in the horse are summarized. The average heritability estimates of pulling ability and cutting ability are .25 and .04, respectively. Heritability estimates are .18, .19 and .17 for log of earnings from jumping, 3-day event and dressage performance, respectively. Heritability estimates of performance rates, log of earnings, earnings, handicap weight, best handicap weight, time and best time for the Thoroughbred are .55, .49, .09, .49, .33, .15 and .23, respectively. Heritability estimates of log of earnings, earnings, time and best time for the trotter are .41, .20, .32, and .25, respectively. The heritability estimate of best time for the pacer is .23. The effectiveness of selection will depend on which performance trait is to be improved. |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0021-8812 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:7440446 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
3758 |
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| Author |
Hamilton, W.D. |
| Title |
The genetical evolution of social behaviour. I |
Type |
Journal Article |
| Year |
1964 |
Publication |
Journal of Theoretical Biology |
Abbreviated Journal |
J. Theor. Biol. |
| Volume |
7 |
Issue |
1and 2 |
Pages |
1-52 |
| Keywords |
*Behavior; *Genetics; Humans; *Models, Theoretical |
| Abstract |
A genetical mathematical model is described which allows for interactions between relatives on one another's fitness. Making use of Wright's Coefficient of Relationship as the measure of the proportion of replica genes in a relative, a quantity is found which incorporates the maximizing property of Darwinian fitness. This quantity is named “inclusive fitness”. Species following the model should tend to evolve behaviour such that each organism appears to be attempting to maximize its inclusive fitness. This implies a limited restraint on selfish competitive behaviour and possibility of limited self-sacrifices.
Special cases of the model are used to show (a) that selection in the social situations newly covered tends to be slower than classical selection, (b) how in populations of rather non-dispersive organisms the model may apply to genes affecting dispersion, and (c) how it may apply approximately to competition between relatives, for example, within sibships. Some artificialities of the model are discussed. |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0022-5193 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:5875341 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
5160 |
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| Author |
Gavrilova, O.; Haluzik, M.; Matsusue, K.; Cutson, J.J.; Johnson, L.; Dietz, K.R.; Nicol, C.J.; Vinson, C.; Gonzalez, F.J.; Reitman, M.L. |
| Title |
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass |
Type |
Journal Article |
| Year |
2003 |
Publication |
The Journal of biological chemistry |
Abbreviated Journal |
J Biol Chem |
| Volume |
278 |
Issue |
36 |
Pages |
34268-34276 |
| Keywords |
Adipose Tissue/*metabolism; Animals; Blotting, Southern; Blotting, Western; Female; Hypoglycemia/genetics; Insulin Resistance/genetics; Lipid Metabolism; Liver/*metabolism; Liver Diseases/genetics/*metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; RNA/metabolism; Receptors, Cytoplasmic and Nuclear/*genetics/*physiology; Recombination, Genetic; Thiazoles/pharmacology; *Thiazolidinediones; Time Factors; Transcription Factors/*genetics/*physiology; Triglycerides/*metabolism |
| Abstract |
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that mediates the antidiabetic effects of thiazolidinediones. PPAR gamma is present in adipose tissue and becomes elevated in fatty livers, but the roles of specific tissues in thiazolidinedione actions are unclear. We studied the function of liver PPAR gamma in both lipoatrophic A-ZIP/F-1 (AZIP) and wild type mice. In AZIP mice, ablation of liver PPAR gamma reduced the hepatic steatosis but worsened the hyperlipidemia, triglyceride clearance, and muscle insulin resistance. Inactivation of AZIP liver PPAR gamma also abolished the hypoglycemic and hypolipidemic effects of rosiglitazone, demonstrating that, in the absence of adipose tissue, the liver is a primary and major site of thiazolidinedione action. In contrast, rosiglitazone remained effective in non-lipoatrophic mice lacking liver PPAR gamma, suggesting that adipose tissue is the major site of thiazolidinedione action in typical mice with adipose tissue. Interestingly, mice without liver PPAR gamma, but with adipose tissue, developed relative fat intolerance, increased adiposity, hyperlipidemia, and insulin resistance. Thus, liver PPAR gamma regulates triglyceride homeostasis, contributing to hepatic steatosis, but protecting other tissues from triglyceride accumulation and insulin resistance. |
| Address |
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. oksanag@bdg10.niddk.nih.gov |
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Thesis |
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Place of Publication |
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Editor |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0021-9258 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:12805374 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
81 |
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| Author |
Edwards, D.H.; Spitzer, N. |
| Title |
6. Social dominance and serotonin receptor genes in crayfish |
Type |
Journal Article |
| Year |
2006 |
Publication |
Current Topics in Developmental Biology |
Abbreviated Journal |
Curr Top Dev Biol |
| Volume |
74 |
Issue |
|
Pages |
177-199 |
| Keywords |
Animals; Astacoidea/*genetics/physiology; Humans; Receptors, Serotonin/*genetics; Serotonin/physiology; *Social Dominance |
| Abstract |
Gene expression affects social behavior only through changes in the excitabilities of neural circuits that govern the release of the relevant motor programs. In turn, social behavior affects gene expression only through patterns of sensory stimulation that produce significant activation of relevant portions of the nervous system. In crayfish, social interactions between pairs of animals lead to changes in behavior that mark the formation of a dominance hierarchy. Those changes in behavior result from changes in the excitability of specific neural circuits. In the new subordinate, circuits for offensive behavior become less excitable and those for defensive behavior become more excitable. Serotonin, which is implicated in mechanisms for social dominance in many animals, modulates circuits for escape and avoidance responses in crayfish. The modulatory effects of serotonin on the escape circuits have been found to change with social dominance, becoming excitatory in dominant crayfish and inhibitory in subordinates. These changes in serotonin's effects on escape affect the synaptic response to sensory input of a single cell, the lateral giant (LG) command neuron for escape. Moreover, these changes occur over a 2-week period and for the subordinate are reversible at any time following a reversal of the animal's status. The results have suggested that a persistent change in social status leads to a gradual change in the expression of serotonin receptors to a pattern that is more appropriate for the new status. To test that hypothesis, the expression patterns of crayfish serotonin receptors must be compared in dominant and subordinate animals. Two of potentially five serotonin receptors in crayfish have been cloned, sequenced, and pharmacologically characterized. Measurements of receptor expression in the whole CNS of dominant and subordinate crayfish have produced inconclusive results, probably because each receptor is widespread in the nervous system and is likely to experience opposite expression changes in different areas of the CNS. Both receptors have recently been found in identified neurons that mediate escape responses, and so the next step will be to measure their expression in these identified cells in dominant and subordinate animals. |
| Address |
Department of Biology, Georgia State University, Atlanta, GA 30302, USA |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0070-2153 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:16860668 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
4364 |
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| Author |
Drent, P.J.; van Oers, K.; van Noordwijk, A.J. |
| Title |
Realized heritability of personalities in the great tit (Parus major) |
Type |
Journal Article |
| Year |
2003 |
Publication |
Proceedings. Biological sciences / The Royal Society |
Abbreviated Journal |
Proc Biol Sci |
| Volume |
270 |
Issue |
1510 |
Pages |
45-51 |
| Keywords |
Aggression; Animals; Animals, Domestic; Animals, Wild; *Behavior, Animal; Breeding; Exploratory Behavior; Female; *Heredity; Male; Selection (Genetics); Songbirds/*genetics/*physiology; Variation (Genetics) |
| Abstract |
Behaviour under conditions of mild stress shows consistent patterns in all vertebrates: exploratory behaviour, boldness, aggressiveness covary in the same way. The existence of highly consistent individual variation in these behavioural strategies, also referred to as personalities or coping styles, allows us to measure the behaviour under standardized conditions on birds bred in captivity, link the standardized measurements to the behaviour under natural conditions and measure natural selection in the field. We have bred the great tit (Parus major), a classical model species for the study of behaviour under natural conditions, in captivity. Here, we report a realized heritability of 54 +/- 5% for early exploratory behaviour, based on four generations of bi-directional artificial selection. In addition to this, we measured hand-reared juveniles and their wild-caught parents in the laboratory. The heritability found in the mid-offspring-mid-parent regression was significantly different from zero. We have thus established the presence of considerable amounts of genetic variation for personality types in a wild bird. |
| Address |
Netherlands Institute of Ecology, PO Box 40, 6666 ZG Heteren, The Netherlands. drent@cto.nioo.knaw.nl |
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Thesis |
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Place of Publication |
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Editor |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0962-8452 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:12590770 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
591 |
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| Author |
de Waal, F.B.; Uno, H.; Luttrell, L.M.; Meisner, L.F.; Jeannotte, L.A. |
| Title |
Behavioral retardation in a macaque with autosomal trisomy and aging mother |
Type |
Journal Article |
| Year |
1996 |
Publication |
American journal of mental retardation : AJMR |
Abbreviated Journal |
Am J Ment Retard |
| Volume |
100 |
Issue |
4 |
Pages |
378-390 |
| Keywords |
Animals; *Behavior, Animal; Brain/physiopathology; Female; Hydrocephalus/complications; Longitudinal Studies; Macaca mulatta/*genetics; Magnetic Resonance Imaging; Male; *Maternal Age; Psychomotor Disorders/*etiology; Social Behavior; Trisomy/*genetics; X Chromosome |
| Abstract |
The social development of a female rhesus monkey (Macaca mulatta) was followed from the day of birth until her death, at age 32 months. The subject, born to an older mother, had an extra autosome (karyotype: 43, XX, +18), an affliction that came about spontaneously. MRI scans revealed that she was also hydrocephalic. Compared to 23 female monkeys growing up under identical conditions, the subject showed serious motor deficiencies, a dramatic delay in the development of social behavior, poorly established dominance relationships, and greater than usual dependency on mother and kin. The subject was well-integrated into the social group, however. |
| Address |
University of Wisconsin-Madison, USA |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0895-8017 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:8718992 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
205 |
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| Author |
de Waal, F.B. |
| Title |
The end of nature versus nurture |
Type |
Journal Article |
| Year |
1999 |
Publication |
Scientific American |
Abbreviated Journal |
Sci Am |
| Volume |
281 |
Issue |
6 |
Pages |
94-99 |
| Keywords |
Animals; *Behavior; Behavior, Animal; Ecology; *Environment; Ethology; Evolution; Female; *Genetics; Humans; Instinct; Learning; Male; Sex Characteristics; Twin Studies |
| Abstract |
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| Address |
Living Links Center, Yerkes Regional Primate Research Center, Atlanta, USA |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0036-8733 |
ISBN |
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Medium |
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Conference |
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| Notes |
PMID:10614071 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
192 |
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| Author |
Crosby, M.B.; Zhang, J.; Nowling, T.M.; Svenson, J.L.; Nicol, C.J.; Gonzalez, F.J.; Gilkeson, G.S. |
| Title |
Inflammatory modulation of PPAR gamma expression and activity |
Type |
Journal Article |
| Year |
2006 |
Publication |
Clinical immunology |
Abbreviated Journal |
Clin Immunol |
| Volume |
118 |
Issue |
2-3 |
Pages |
276-283 |
| Keywords |
Age Factors; Animals; Cell Line, Transformed; Cells, Cultured; Female; Inflammation Mediators/*physiology; Kidney/metabolism; Mesangial Cells/metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Knockout; Nitric Oxide/biosynthesis; Nitric Oxide Synthase Type II/biosynthesis/genetics; PPAR gamma/*biosynthesis/*genetics/metabolism; Up-Regulation/immunology |
| Abstract |
Nitric oxide (NO) production increases with age in the lupus-prone MRL/lpr mouse, paralleling disease activity. One mechanism for excess NO production in MRL/lpr mice may be a defect in down-regulatory mechanisms of the iNOS pathway. A potential modulator of NO is the nuclear hormone receptor peroxisome proliferation activated receptor gamma (PPARgamma). We demonstrate that renal PPARgamma protein expression was altered as disease progressed in MRL/lpr mice, which paralleled increased iNOS protein expression. Additionally, MRL/lpr-derived primary mesangial cells expressed less PPARgamma than BALB/c mesangial cells and produced more NO in response to LPS and IFNgamma. Furthermore, PPARgamma activity was reduced in mesangial cells following exposure to inflammatory mediators. This activity was restored with the addition of a NOS enzyme inhibitor. These results indicate that the activation of inflammatory pathways may lead to reduced activity and expression of PPARgamma, further exacerbating the disease state. |
| Address |
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA |
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Thesis |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1521-6616 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:16303334 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
67 |
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| Author |
Cilnis, M.J.; Kang, W.; Weaver, S.C. |
| Title |
Genetic conservation of Highlands J viruses |
Type |
Journal Article |
| Year |
1996 |
Publication |
Virology |
Abbreviated Journal |
Virology |
| Volume |
218 |
Issue |
2 |
Pages |
343-351 |
| Keywords |
Alphavirus/*genetics; Alphavirus Infections/transmission/veterinary/virology; Amino Acid Sequence; Animals; Base Sequence; Conserved Sequence; Disease Outbreaks; Encephalitis, Viral/veterinary/virology; *Evolution, Molecular; Horses; Molecular Sequence Data; Phylogeny; RNA, Viral/genetics; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Turkeys; Variation (Genetics)/*genetics |
| Abstract |
We studied molecular evolution of the mosquito-borne alphavirus Highlands J (HJ) virus by sequencing PCR products generated from 19 strains isolated between 1952 and 1994. Sequences of 1200 nucleotides including portions of the E1 gene and the 3' untranslated region revealed a relatively slow evolutionary rate estimated at 0.9-1.6 x 10(-4) substitutions per nucleotide per year. Phylogenetic trees indicated that all HJ viruses descended from a common ancestor and suggested the presence of one dominant lineage in North America. However, two or more minor lineages probably circulated simultaneously for periods of years to a few decades. Strains isolated from a horse suffering encephalitis, and implicated in a recent turkey outbreak, were not phylogenetically distinct from strains isolated in other locations during the same time periods. Our findings are remarkably similar to those we obtained previously for another North American alphavirus, eastern equine encephalomyelitis virus, with which Highlands J shares primary mosquito and avian hosts, geographical distribution, and ecology. These results support the hypotheses that the duration of the transmission season affects arboviral evolutionary rates and vertebrate host mobility influences genetic diversity. |
| Address |
Department of Biology, University of California, San Diego, La Jolla 92093-0116, USA |
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Thesis |
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Place of Publication |
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Editor |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0042-6822 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:8610461 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2657 |
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| Author |
Chilton, N.B. |
| Title |
The use of nuclear ribosomal DNA markers for the identification of bursate nematodes (order Strongylida) and for the diagnosis of infections |
Type |
Journal Article |
| Year |
2004 |
Publication |
Animal Health Research Reviews / Conference of Research Workers in Animal Diseases |
Abbreviated Journal |
Anim Health Res Rev |
| Volume |
5 |
Issue |
2 |
Pages |
173-187 |
| Keywords |
Animals; Birds; Cats; DNA Primers; DNA, Helminth/*analysis; DNA, Ribosomal/*analysis; Dogs; Horses; Molecular Diagnostic Techniques/veterinary; Ruminants; Strongylida/*genetics; Strongylida Infections/diagnosis/*veterinary |
| Abstract |
Many bursate nematodes are of major importance to animal health. Animals are often parasitized by multiple species that differ in their prevalence, relative abundance and/or pathogenicity. Implementation of effective management strategies for these parasites requires reliable methods for their detection in hosts, identification to the species level and measurement of intensity of infection. One major problem is the difficulty of accurately identifying and distinguishing many species of bursate nematode because of the remarkable morphological similarity of their eggs and larvae. The inability to identify, with confidence, individual nematodes (irrespective of their life-cycle stage) to the species level by morphological methods has often led to a search for species-specific genetic markers. Studies over the past 15 years have shown that sequences of the internal transcribed spacers of ribosomal DNA provide useful genetic markers, providing the basis for the development of PCR-based diagnostic tools. Such molecular methods represent powerful tools for studying the systematics, epidemiology and ecology of bursate nematodes and, importantly, for the specific diagnosis of infections in animals and humans, thus contributing to improved control and prevention strategies for these parasites. |
| Address |
Department of Biology, University of Saskatchewan, 112 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada. neil.chilton@usask.ca |
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Thesis |
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Place of Publication |
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Editor |
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English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1466-2523 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:15984323 |
Approved |
no |
| Call Number |
Equine Behaviour @ team @ |
Serial |
2628 |
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