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Author Houpt, K.A.; Wolski, T.R. openurl 
  Title Stability of equine hierarchies and the prevention of dominance related aggression Type Journal Article
  Year 1980 Publication Equine veterinary journal Abbreviated Journal Equine Vet J  
  Volume 12 Issue 1 Pages 15-18  
  Keywords *Aggression; Animals; *Behavior, Animal; Feeding Behavior; Female; *Hierarchy, Social; *Horses; Humans; Male; Maternal Behavior; *Social Dominance  
  Abstract The dominance hierarchy of a herd of 10 Thoroughbred mares was determined twice, at an interval of 18 months, using paired feeding tests. Each mare's rank was correlated significantly between the 2 tests. This indicated that the hierarchy within the herd was stable. The offspring of dominant and subordinate mares were also tested for dominance in their own age groups. The offspring of dominant mares tended to be near the top of the hierarchy while those of middle and low ranking mares were not consistently found in the middle or bottom of their own hierarchies. Paired feeding tests were carried out on 8 ponies. During tests the time that each pony spent eating and the ponies' aggressive interactions were recorded. Two situations were used. Each pony-pair was tested when both ponies were in the same paddock and also when they were separated by a rail fence. The subordinate ponies spent significantly more time eating and the domonant pony was significantly less aggressive, when the pony-pair was separated by a fence than when they were in one paddock. It was concluded that the dominance hierarchies of adult horse groups changed very little over time and that the foals of dominant mares will tend to be dominant in their own age groups. Management practices can be used to reduce aggression and consequent injury that may arise in group feeding situations.  
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  Series Volume Series Issue Edition  
  ISSN 0425-1644 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:7189148 Approved (down) no  
  Call Number refbase @ user @ Serial 59  
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Author Brown, R.F.; Houpt, K.A.; Schryver, H.F. openurl 
  Title Stimulation of food intake in horses by diazepam and promazine Type Journal Article
  Year 1976 Publication Pharmacology, biochemistry, and behavior Abbreviated Journal Pharmacol Biochem Behav  
  Volume 5 Issue 4 Pages 495-497  
  Keywords Age Factors; Animals; Diazepam/*pharmacology; Diet; Feeding Behavior/*drug effects; Female; Horses/*physiology; Male; Promazine/*pharmacology; Stimulation, Chemical  
  Abstract In two adult horses doses of 0.02-0.03 mg/kg diazepam, intravenously, increased 1 hr intake 54-75% above control levels. Intake was stimulated when the diet was a high grain, calorically dense one and also when the diet was a high fiber, calorically dilute one. Two young rapidly growing weanling horses showed an even more pronounced stimulation of intake. Following diazepam 1 hr intake was increased 105-240% above control lelvels. Promazine at a dose of 0.5 mg/kg also stimulated intake in adult horses, but not as markedly as did diazepam. A transquilizer and a neuroleptic appear to have a stimulatory eff upon short-term intake in horses.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0091-3057 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:1005496 Approved (down) no  
  Call Number refbase @ user @ Serial 60  
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Author Houpt, K.A. openurl 
  Title Animal behavior as a subject for veterinary students Type Journal Article
  Year 1976 Publication The Cornell veterinarian Abbreviated Journal Cornell Vet  
  Volume 66 Issue 1 Pages 73-81  
  Keywords Aggression; Animals; *Behavior, Animal; Cats; Chickens; Dogs; Education, Veterinary; Goats; Horses; Humans; Maternal Behavior; Mice; New York; Sexual Behavior, Animal; Sheep; Sleep; Social Behavior; Social Dominance; Swine  
  Abstract Knowledge of animal behavior is an important asset for the veterinarian; therefore a course in veterinary animal behavior is offered at the New York State College of Veterinary Medicine as an elective. The course emphasizes the behavior of those species of most interest to the practicing veterinarian: cats, dogs, horses, cows, pigs and sheep. Dominance heirarchies, animal communication, aggressive behavior, sexual behavior and maternal behavior are discussed. Play, learning, diurnal cycles of activity and sleep, and controls of ingestive behavior are also considered. Exotic and zoo animal behaviors are also presented by experts in these fields. The critical periods of canine development are related to the optimum management of puppies. The behavior of feral dogs and horses is described. The role of the veterinarian in preventing cruelty to animals and recognition of pain in animals is emphasized. Whenever possible behavior is observed in the laboratory or on film.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0010-8901 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:767053 Approved (down) no  
  Call Number refbase @ user @ Serial 61  
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Author Houpt, T.R.; Houpt, K.A. openurl 
  Title Nitrogen conservation by ponies fed a low -protein ration Type Journal Article
  Year 1971 Publication American journal of veterinary research Abbreviated Journal Am J Vet Res  
  Volume 32 Issue 4 Pages 579-588  
  Keywords Administration, Oral; Amino Acids/biosynthesis; Animals; Anti-Infective Agents/pharmacology; Body Weight/drug effects; Dietary Proteins/*pharmacology; Horses/*metabolism; Nitrogen/*metabolism; Urea/administration & dosage/antagonists & inhibitors/metabolism; Water/metabolism  
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  Series Volume Series Issue Edition  
  ISSN 0002-9645 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:5110116 Approved (down) no  
  Call Number refbase @ user @ Serial 62  
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Author Dixon, G.; Green, L.E.; Nicol, C.J. doi  openurl
  Title Effect of diet change on the behavior of chicks of an egg-laying strain Type Journal Article
  Year 2006 Publication Journal of applied animal welfare science : JAAWS Abbreviated Journal J Appl Anim Welf Sci  
  Volume 9 Issue 1 Pages 41-58  
  Keywords *Animal Feed; *Animal Nutrition Physiology; Animals; Behavior, Animal/*physiology; Chickens/*physiology; Crowding; Feeding Behavior/*physiology; Female; Food Preferences/physiology; Oviposition; Random Allocation; Taste  
  Abstract Injurious pecking has serious welfare consequences in flocks of hens kept for egg laying, especially when loose-housed. Frequent diet change is a significant risk for injurious pecking; how the mechanics of diet change influence pecking behavior is unknown. This study investigated the effect of diet change on the behavior of chicks from a laying strain. The study included a 3-week familiarity phase: 18 chick pairs received unflavored feed (Experiment 1); 18 pairs received orange oil-flavored (Experiment 2). All chicks participated in a dietary preference test (P); a diet change (DC); or a control group (C), 6 scenarios. All P chicks preferred unflavored feed. In Experiment 1, DC involved change from unflavored to orange-flavored; Experiment 2, orange- flavored to unflavored. Compared with controls, Experiment 2 DC chicks exhibited few behavioral differences; Experiment 1 DC chicks exhibited increased behavioral event rates on Days 1 and 7. They pecked significantly longer at their environment; by Day 7, they showed significantly more beak activity. There was little evidence of dietary neophobia. Change from more preferred to less preferred feed led to increased activity and redirected pecking behavior.  
  Address School of Veterinary Science, University of Bristol, England  
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  Series Volume Series Issue Edition  
  ISSN 1088-8705 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16649950 Approved (down) no  
  Call Number refbase @ user @ Serial 64  
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Author Nicol, C.J.; Brown, S.N.; Glen, E.; Pope, S.J.; Short, F.J.; Warriss, P.D.; Zimmerman, P.H.; Wilkins, L.J. doi  openurl
  Title Effects of stocking density, flock size and management on the welfare of laying hens in single-tier aviaries Type Journal Article
  Year 2006 Publication British poultry science Abbreviated Journal Br Poult Sci  
  Volume 47 Issue 2 Pages 135-146  
  Keywords Animal Husbandry/*methods; *Animal Welfare; Animals; Body Constitution/*physiology; Chickens/*physiology; Crowding; Feathers; Female; *Housing, Animal/standards; Mortality; Organ Size; Oviposition/physiology; Population Density; Population Dynamics; Random Allocation  
  Abstract Management practices, stocking rate and flock size may affect laying hen welfare but there have been few replicated studies in commercial non-cage systems that investigate this. This study used a broad range of physical and physiological indicators to assess the welfare of hens in 36 commercial flocks. Six laying period treatments were examined with each treatment replicated 6 times. It was not possible to randomly allocate treatments to houses, so treatment and house were largely confounded. Three stocking rates were compared: 7 birds/m(2) (n = 2450), 9 birds/m(2) (n = 3150) and 12 birds/m(2) in either small (n = 2450) or large (n = 4200) flocks. In addition, at 12 birds/m(2), in both small and large flocks, birds were subjected to either standard (SM) or modified (MM) management. MM flocks had nipple drinkers and no nest-box lights. Bone strength, fracture incidence, heterophil:lymphocyte (H:L) ratio, live weight, organ weights, serum creatine, serum osmolality, muscle pH and faecal corticosterone were measured on samples of birds at the end of the rearing period and at the end of lay. During the laying period, mortality, production and integument condition were recorded at regular intervals. Birds housed at 9 birds/m(2) had higher mortality than birds housed at 12 birds/m(2) by the end of lay, but not higher than birds housed at 7 birds/m(2). Birds housed at 7 and 9 birds/m(2) had lower percent liver weight, and worse plumage condition than most of the 12 bird/m(2) treatments. Modified management tended to improve plumage condition. There were no clear effects of flock size on the welfare indicators recorded. At the end of the rearing period fracture incidence was almost negligible and H:L ratio was within a normal range. By the end of lay fracture incidence was 60% and H:L ratio was high, with no treatment effect for either measure. This, together with information on faecal corticosterone, feather loss and mortality, suggests that the welfare of birds in all treatments was relatively poor by the end of lay.  
  Address School of Veterinary Science, University of Bristol, Langford House, Langford BS40 5DU and ADAS Gleadthorpe, Meden Vale, Mansfield, Notts NG20 9PF, England. c.j.nicol@bristol.ac.uk  
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  Series Volume Series Issue Edition  
  ISSN 0007-1668 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:16641024 Approved (down) no  
  Call Number refbase @ user @ Serial 65  
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Author Haslam, S.M.; Brown, S.N.; Wilkins, L.J.; Kestin, S.C.; Warriss, P.D.; Nicol, C.J. doi  openurl
  Title Preliminary study to examine the utility of using foot burn or hock burn to assess aspects of housing conditions for broiler chicken Type Journal Article
  Year 2006 Publication British poultry science Abbreviated Journal Br Poult Sci  
  Volume 47 Issue 1 Pages 13-18  
  Keywords Animal Husbandry; *Animal Welfare; Animals; Chickens; Dermatitis, Contact/diagnosis/pathology/*veterinary; Feathers; Female; Foot Diseases/diagnosis/pathology/*veterinary; *Housing, Animal; Male; Poultry Diseases/diagnosis/*pathology; Skin/pathology  
  Abstract 1. Eleven broiler chicken farms, representing 4 production system types, were visited during the last 5 d of the flock cycle: bird and flock details were recorded. Litter friability was assessed at 9 sites within the house, atmospheric ammonia was measured at three sites and bird cleanliness was assessed on a numerical rating scale. 2. For these flocks, hock burn, foot burn and breast burn were measured at the processing plant by standardised assessors. 3. Significant correlations were identified between the percentage of birds with foot burn and average litter score, average house ammonia concentrations and feather score. 4. No correlation was found between the percentage of birds with hock burn or breast burn and average litter scores, average ammonia concentrations or feather score. 5. No correlation was found between stocking density and foot burn, hock burn or breast burn.6. If confirmed, these findings may have implications for the draft EU Broiler Directive, for which it is proposed that permitted stocking density on farm may be determined by the incidence and severity of contact dermatitis measured on plant.  
  Address Division of Farm Animal Science, School of Veterinary Science, University of Bristol, Bristol, England. sue.haslam@bris.ac.uk  
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  Series Volume Series Issue Edition  
  ISSN 0007-1668 ISBN Medium  
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  Notes PMID:16546791 Approved (down) no  
  Call Number refbase @ user @ Serial 66  
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Author Crosby, M.B.; Zhang, J.; Nowling, T.M.; Svenson, J.L.; Nicol, C.J.; Gonzalez, F.J.; Gilkeson, G.S. doi  openurl
  Title Inflammatory modulation of PPAR gamma expression and activity Type Journal Article
  Year 2006 Publication Clinical immunology Abbreviated Journal Clin Immunol  
  Volume 118 Issue 2-3 Pages 276-283  
  Keywords Age Factors; Animals; Cell Line, Transformed; Cells, Cultured; Female; Inflammation Mediators/*physiology; Kidney/metabolism; Mesangial Cells/metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Knockout; Nitric Oxide/biosynthesis; Nitric Oxide Synthase Type II/biosynthesis/genetics; PPAR gamma/*biosynthesis/*genetics/metabolism; Up-Regulation/immunology  
  Abstract Nitric oxide (NO) production increases with age in the lupus-prone MRL/lpr mouse, paralleling disease activity. One mechanism for excess NO production in MRL/lpr mice may be a defect in down-regulatory mechanisms of the iNOS pathway. A potential modulator of NO is the nuclear hormone receptor peroxisome proliferation activated receptor gamma (PPARgamma). We demonstrate that renal PPARgamma protein expression was altered as disease progressed in MRL/lpr mice, which paralleled increased iNOS protein expression. Additionally, MRL/lpr-derived primary mesangial cells expressed less PPARgamma than BALB/c mesangial cells and produced more NO in response to LPS and IFNgamma. Furthermore, PPARgamma activity was reduced in mesangial cells following exposure to inflammatory mediators. This activity was restored with the addition of a NOS enzyme inhibitor. These results indicate that the activation of inflammatory pathways may lead to reduced activity and expression of PPARgamma, further exacerbating the disease state.  
  Address Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA  
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  Series Volume Series Issue Edition  
  ISSN 1521-6616 ISBN Medium  
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  Notes PMID:16303334 Approved (down) no  
  Call Number refbase @ user @ Serial 67  
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Author Nicol, C.J.; Adachi, M.; Akiyama, T.E.; Gonzalez, F.J. doi  openurl
  Title PPARgamma in endothelial cells influences high fat diet-induced hypertension Type Journal Article
  Year 2005 Publication American journal of hypertension : journal of the American Society of Hypertension Abbreviated Journal Am J Hypertens  
  Volume 18 Issue 4 Pt 1 Pages 549-556  
  Keywords Administration, Oral; Animals; Antihypertensive Agents/pharmacology; Blood Pressure/drug effects; Diabetes Mellitus, Type 2/physiopathology; Dietary Fats/*administration & dosage/pharmacology; Dose-Response Relationship, Drug; Endothelial Cells/*metabolism; Female; Heart Rate/drug effects; Hypertension/*etiology; Ligands; Male; Mice; Mice, Knockout; PPAR gamma/*metabolism; Sodium Chloride/administration & dosage/pharmacology; Thiazolidinediones/pharmacology  
  Abstract BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands improve human hypertension. However, the mechanism and site of this effect remains unknown, confounded by PPARgamma expression in many cell types, including endothelial cells (ECs). METHODS: To evaluate the vascular role of PPARgamma we used a conditional null mouse model. Specific disruption of PPARgamma in ECs was created by crossing Tie2-Cre+ transgenic (T2T+) and PPARgamma-floxed (fl/fl) mice to generate PPARgamma (fl/fl)T2T+ (PPARgamma E-null) mice. Conscious 8- to 12-week-old congenic PPARgamma (fl/fl)Cre- (wild type) and PPARgamma E-null mice were examined for changes in systolic blood pressure (BP) and heart rate (HR), untreated, after 2 months of salt-loading (drinking water), and after treatment for 3 months with high fat (HF) diet alone or supplemented during the last 2 weeks with rosiglitazone (3 mg/kg/d). RESULTS: Untreated PPARgamma E-nulls were phenotypically indistinguishable from wild-type littermates. However, compared to similarly treated wild types, HF-treated PPARgamma E-nulls had significantly elevated systolic BP not seen after normal diet or salt-loading. Despite sex-dependent baseline differences, salt-loaded and HF-treated PPARgamma E-nulls of either sex had significantly elevated HR versus wild types. Interestingly, rosiglitazone improved serum insulin levels, but not HF diet-induced hypertension, in PPARgamma E-null mice. CONCLUSIONS: These results suggest that PPARgamma in ECs not only is an important regulator of hypertension and HR under stressed conditions mimicking those arising in type 2 diabetics, but also mediates the antihypertensive effects of rosiglitazone. These data add evidence supporting a beneficial role for PPARgamma-specific ligands in the treatment of hypertension, and suggest therapeutic strategies targeting ECs may prove useful.  
  Address Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA  
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  Series Volume Series Issue Edition  
  ISSN 0895-7061 ISBN Medium  
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  Notes PMID:15831367 Approved (down) no  
  Call Number refbase @ user @ Serial 69  
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Author Wilkins, L.J.; Brown, S.N.; Zimmerman, P.H.; Leeb, C.; Nicol, C.J. openurl 
  Title Investigation of palpation as a method for determining the prevalence of keel and furculum damage in laying hens Type Journal Article
  Year 2004 Publication The Veterinary record Abbreviated Journal Vet. Rec.  
  Volume 155 Issue 18 Pages 547-549  
  Keywords Animal Husbandry/methods; Animal Welfare; Animals; Bone and Bones/*injuries; Chickens/*injuries; Female; Fractures, Bone/diagnosis/epidemiology/*veterinary; Great Britain/epidemiology; Housing, Animal/standards; Oviposition; Palpation/methods/*veterinary; Poultry Diseases/*diagnosis/epidemiology; Prevalence; Sensitivity and Specificity  
  Abstract Old breaks of the keel and furculum were identified by palpation in 500 end-of-lay hens from 10 flocks housed in free-range and barn systems, and the results were compared with the results obtained by a full dissection and inspection. The method was considered to be sufficiently precise to be used as a diagnostic tool although people using it would need to be trained. The results obtained by dissection indicated that 50 to 78 per cent of the birds in the flocks had breaks of the furculum and keel, but no other breaks of bones were detected.  
  Address Department of Clinical Veterinary Science, University of Bristol, Bristol BS40 5DU  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0042-4900 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:15559420 Approved (down) no  
  Call Number refbase @ user @ Serial 70  
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