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Author Granquist, S.M.; Thorhallsdottir, A.G.; Sigurjonsdottir, H.
Title The effect of stallions on social interactions in domestic and semi feral harems Type Journal Article
Year 2012 Publication Applied Animal Behaviour Science Abbreviated Journal (up)
Volume 141 Issue 1–2 Pages 49-56
Keywords Horses; Hierarchy; Icelandic horse; Social behaviour; Social bonds
Abstract Earlier research indicates that stallions may supress interactions of their harem members, leading to less stable hierarchies and friendship bonds in harems compared to non-stallion groups. In this paper, the effect of the presense of a stallion on the social behaviour of mares was studied by comparing six harems containing stallions to four mixed sex groups not containing stallions. Both temporary and permanent harems were studied, giving the possibility to investigate the effect of group stability on social interactions. A significant linear hierarchy was found in all non-stallion groups that were used for comparison, while the hierarchies were only found to be linear in three of the six harems containing stallions (Landaus h', p < 0.05). Aggression rate was lower (t-test, p < 0.05) and fewer friendship bonds (G-test, p < 0.0001) were found within the harems, compared to the groups without stallions. Stallions seldom intervene directly in interactions between harem members. Thus, our results give support to the hypothesis that stallions may suppress interactions of harem members, but in a more indirect way than with direct interference. In addition, our results give support for earlier findings that aggression rate may be affected by group stability. We found a higher aggression rate in the temporary harems compared to the permanent harems (Kruskal–Wallis, p < 0.05) and in the temporary non-stallion group compared to the permanent non-stallion group. The results have significance for further research on social structure of mammals, and may be applied in management of domestic animals.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-1591 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5619
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Author Ben-Shlomo, G.; Plummer, C.; Barrie, K.; Brooks, D.
Title Characterization of the normal dark adaptation curve of the horse Type Journal Article
Year 2012 Publication Veterinary Ophthalmology Abbreviated Journal (up)
Volume 15 Issue 1 Pages 42-45
Keywords adaptation; curve; dark; electroretinography; equine; scotopic
Abstract Objective The goal of this work is to study the dark adaptation curve of the normal horse electroretinogram (ERG). Procedures The electroretinographic responses were recorded from six healthy female ponies using a contact lens electrode and a mini-Ganzfeld electroretinographic unit. The horses were sedated intravenously with detomidine, an auriculopalpebral nerve block was then performed, and the pupil was fully dilated. The ERG was recorded in response to a low intensity light stimulus (30 mcd.s/m2) that was given at times (T) T = 5, 10, 15, 20, 25, 30, 40, 50, and 60 min of dark adaptation. Off-line analysis of the ERG was then performed. Results Mean b-wave amplitude of the full-field ERG increased continuously from 5 to 25 min of dark adaptation. The b-wave amplitude peaked at T = 25, however, there was no statistical significance between T = 20 and T = 25. The b-wave amplitude then remained elevated with no significant changes until the end of the study at T = 60 (P > 0.49). The b-wave implicit time increased continuously between T = 5 and T = 20, then gradually decreased until T = 60. No distinct a-wave was observed during the testing time. Conclusions Evaluation of horse rod function or combined rod/cone function by means of full-field ERG should be performed after a minimum 20 min of dark adaptation.
Address
Corporate Author Thesis
Publisher Blackwell Publishing Ltd Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1463-5224 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5626
Permanent link to this record
 

 
Author Hoffmann; G.
Title Bewegungsaktivität und Stressbelastung bei Pferden in Auslaufhaltungssystemen mit verschiedenen Bewegungsangeboten Type Manuscript
Year 2008 Publication Dissertation Abbreviated Journal (up)
Volume Issue Pages
Keywords
Abstract Pferdehaltungssysteme mit angrenzenden Ausläufen gelten als eine sehr tiergerechte

Haltungsform, da sie den Tieren eine gewisse Bewegungsmöglichkeit

bieten. Ziel der vorliegenden Untersuchung war es, zu erfassen, ob der angrenzende

Auslauf selbst einen ausreichenden Anreiz zur Bewegung darstellt und wie sich verschiedene

Bewegungs- und Platzangebote auf die Bewegungsaktivität von Pferden

in einer Gruppen-Auslaufhaltung auswirken. Zudem wurde ermittelt, welche Auswirkung

die Bewegungsform bzw. –intensität auf das Wohlbefinden der Tiere hat.

Der Großteil der in Deutschland gehaltenen Pferde verbringt die meiste Zeit des

Tages im Stall, obwohl mittlerweile bekannt ist, dass Pferde unter natürlichen

Haltungsbedingungen 12 bis 16 Stunden des Tages in Bewegung verbringen. Der

Optimierung der Stallhaltungssysteme gilt daher ein besonderes Interesse.

Zu diesem Zweck wurden von September 2004 bis Oktober 2005 Versuche mit 24

Warmblutstuten im Alter von 1½ bis 3½ Jahren in Einzel- und Gruppen-

Auslaufhaltungssystemen durchgeführt. Jeweils sechs Pferde bildeten eine Versuchsgruppe.

In jeder Gruppe fanden fünf Varianten von einer ca. dreiwöchigen

Dauer statt. Die Gruppenhaltung wurde dabei durch drei unterschiedliche Zusatzbewegungsangebote

(2 Std. Weide / Tag, 2 Std. unbegrünte Koppel / Tag, 1 Std. Freilauf-

Führanlage / Tag) ergänzt. In der Einzel-Auslaufhaltung (Box mit 45 m²-großem

angrenzenden Auslauf) und in einer Versuchsvariante der Gruppenhaltung bekamen

die Pferde hingegen keine zusätzliche Bewegung außerhalb des Stallhaltungssystems

angeboten. Das Gruppenhaltungssystem selbst war durch die räumliche

Trennung der Funktionsbereiche (Liegen, Fressen, Trinken, Bewegen) gekennzeichnet

und der angrenzende Auslauf war 270 m² groß. In einer zusätzlichen Versuchsphase

fand in der Gruppenhaltung eine Erweiterung des permanent zugänglichen

Auslaufs auf insg. 540 m² statt.

Die Bewegungsaktivität wurde mit Pedometern erfasst, die an jeweils einem Hinterbein

der Pferde befestigt wurden und ergänzend fand eine Analyse von Videoaufzeichnungen

statt. Zur Beurteilung der Stressbelastung fanden Messungen der Herz192

Zusammenfassung

frequenzvariabilität (Parameter HF und SD2) und der fäkalen Cortisolmetabolitenkonzentration

statt.

Die Auswertung des Bewegungsverhaltens ergab, dass eine zusätzliche zweistündige

freie Bewegung der Pferdegruppe auf einer Weide zu einer deutlichen

Steigerung der durchschnittlichen Bewegungsaktivität (149,6 Min. / Tag) führt,

ebenso wie eine einstündige Bewegung in einer Führanlage (173,0 Min. / Tag). Eine

unbegrünte Koppel regte die Pferde der Gruppenhaltung hingegen nicht zu vermehrter

Bewegung an (131,6 Min. / Tag), sondern bewirkte z. T. sogar eine Abnahme

der Bewegungsaktivität. In der Gruppen-Auslaufhaltung ohne zusätzliches Bewegungsangebot

war die Bewegungsaktivität ebenfalls gering (125,8 Min / Tag) und

während der Einzel-Auslaufhaltung ohne Zusatzbewegung zeigten die Pferde die

geringste Bewegungsaktivität (102,3 Min. / Tag).

Bei der alleinigen Analyse der Bewegungszeit im Stallhaltungssystem war kein signifikanter

Einfluss der zusätzlichen Bewegung außerhalb des Stallsystems auf die

übrige Fortbewegung feststellbar.

Auch eine Vergrößerung des an den Stall angrenzenden Auslaufs im Gruppenhaltungssystem

hatte keinen steigernden Einfluss auf das Bewegungsverhalten der

Pferde.

Die Stressbelastung der Pferde war in den Varianten der Gruppenhaltung mit zweistündigem

Weidegang (SD2: 82,9 ms; Cortisolmetaboliten: 29,0 nmol / kg Kot) sowie

der einstündigen Bewegung in einer Freilauf-Führanlage (SD2: 99,2 ms; Cortisolmetaboliten:

27,7 nmol / kg Kot) am geringsten. Die Untersuchungen zeigten eine

Stresszunahme in der Gruppenhaltung mit zweistündigem Auslauf auf einer unbegrünten

Koppel ohne Futterangebot (SD2: 101,3 ms; Cortisolmetaboliten:

39,6 nmol / kg Kot) sowie in der Variante der Gruppenhaltung ohne zusätzliches Bewegungsangebot

(SD2: 113,3 ms; Cortisolmetaboliten: 38,4 nmol / kg Kot). Dem

Mittelwert der Gruppe nach zu folgern hatten die Pferde während der Einzelhaltung

ohne Zusatzbewegung eine sehr große Stressbelastung (SD2: 123,8 ms; Cortisolmetaboliten:

37,5 nmol / kg Kot). Ein Vergleich der Gruppen- und Einzelhaltung hinsichtlich

der Herzfrequenzvariabilität hat jedoch gezeigt, dass insg. 70 % der Pferde

während der Haltung in einer Gruppe weniger Stress empfinden. Es gab aber auch

Zusammenfassung 193

Pferde (30 %), die in der Einzelhaltung eine abnehmende Stressbelastung zeigten,

wobei hier der Einfluss der Rangordnung eine entscheidende Rolle zu spielen

scheint.

Durch die Auswertung mehrerer Messparameter (sowohl für Stress- als auch für Bewegungsverhalten)

werden gleichgerichtete Tendenzen bei den Versuchsvarianten

deutlich, allerdings ist eine eindeutige Gewichtung der Parameter nicht möglich.

Somit ist die methodische Vorgehensweise dieser Untersuchung sehr positiv und als

notwendig anzusehen, da die Messdaten auch immer gewissen Schwankungen

durch externe Einflüsse unterliegen.

Allgemein ist festzuhalten, dass Auslaufhaltungssysteme zwar eine gewisse

Anregung zur Bewegung bieten, aber mit maximal vier Stunden (insg. 62 – 248 Min.)

Bewegung pro Tag war der tägliche Anteil an Bewegung sehr viel geringer als

beispielsweise bei Pferden in freier Wildbahn oder ganzjähriger Weidehaltung. Somit

deckt ein Auslaufhaltungssystem trotz getrennter Funktionsbereiche und eines

großen Auslaufs nicht den Bewegungsbedarf der Pferde, wenn keine zusätzlichen

Bewegungsanreize und –möglichkeiten angeboten werden.

Eine zusätzliche Bewegung von Pferden ist nicht nur zur Gesunderhaltung des

Bewegungsapparates und der Körperfunktionen notwendig, sondern auch um das

Wohlbefinden und die Ausgeglichenheit der Pferde zu steigern.

[Horse husbandry systems with close-by discharge are considered to be a very livestock-

friendly housing form, as they offer a certain movement opportunity for the

animals. The aim of the present study was to examine how different movement and

space offerings affect the movement activities of horses in a group horse husbandry

with close-by discharge, and whether the discharge provides itself an adequate

incentive for movement. The impact that the form or rather intensity of movement has

on the wellbeing of the animals was also established.

Most of the horses held in Germany spend most of the day in the stable, although it is

meanwhile known that horses under natural housing conditions are 12 to 16 hours of

the day in motion. Therefore the improvement of stable housing systems applies a

special interest.

For this purpose, 24 warmblood mares, aged from 1½ to 3½ years, were studied in

single and group discharge husbandry systems from September 2004 until October

2005. Six horses formed an experimental group. In every group five variants of approximately

three weeks were proceeded. Thereby the group husbandry was supplemented

with three different additional movement opportunities (2 h pasture / day,

2 h non-grassy pasture land / day, 1 h free range horse walker / day). In the single

discharge husbandry (single box with 45 sq. m-large close-by discharge) and in one

experimental variant of the group husbandry got the horses, however, offered no additional

movement outside the husbandry system. The group husbandry system itself

was marked by the spatial division of the functional areas (lying, eating, drinking,

moving) and the close-by discharge measured 270 sq. m. In an additional phase of

the study, and expansion of the permanently accessible close-by discharge to

540 sq. m was found.

The movement activity was documented with pedometers attached respectively to

one hind leg of the horse and a supplementary analysis of video documentation. To

evaluate the stress exposure measurements of heart frequency variability (parameters

HF and SD2) and of the faecal cortisol metabolite concentration were performed.

Summary 195

The interpretation of the movement behaviour showed that additional two hours of

free movement on a pasture led to a significant increase in the average movement

activity (149.6 min / day), as well as one hour movement in a horsewalker did

(173.0 min / day). The non-grassy pasture land, however, didn’t inspire the horses of

the group husbandry to increased movement (131.6 min / day), but sometimes even

caused a decrease in movement activity. In the group discharge husbandry without

additional movement opportunities the movement activity was also low

(125.8 min / day), and during the single discharge husbandry without additional

movement the horses showed the least movement activity (102.3 min / day).

In analysing only the movement time in the stable system was no significant impact

of the additional movement outside the housing system to the rest of locomotion

ascertainable.

As well an expansion of the close-by stable discharge in the group husbandry system

had no increasing influence on the movement behaviour of the horses.

The stress exposure of the horses was least in the variations of group husbandry

with two hours on a pasture (SD2: 82.9 ms; cortisol metabolites: 29.0 nmol / kg faeces)

as well as one hour of movement in a free range horse walker (SD2: 99.2 ms;

cortisol metabolites: 27.7 nmol / kg faeces). The studies showed a rise in stress in

group husbandry with two hours of movement on a non-grassy pasture land without

feeding opportunity (SD2: 101.3 ms; cortisol metabolites: 39.6 nmol / kg faeces) as

well as in the variation of the group husbandry without additional movement offerings

(SD2: 113.3 ms; cortisol metabolites: 38.4 nmol / kg faeces). Judging from the mean

of the group the horses had a very high stress exposure in the variation of the single

husbandry without additional movement offerings (SD2: 123.8 ms; cortisol metabolites:

37.5 nmol / kg faeces). But a comparison of the group and single husbandry in

terms of the heart frequency variability showed that alltogether 70 % of the horses

experienced less stress if hold in a group. However, some horses (30 %) showed

reducing stress in the single husbandry, whereas here the influence of social hierarchy

seems to play a decisive role.

196 Summary

In consequence of the examination of several measuring parameters (both for stressand

for movement behaviour) parallel aligned tendencies become apparent in the

experimental variants, however, is a unique weighting of the parameters not possible.

Thus, the methodological approach of this study is to be regarde as very positive and

necessary, since the data always vary with some fluctuations by external influences.

In general it can be established that discharge husbandry systems offer some incentive

for the horse to move, but with a maximum of four hours (overall 62 – 248 min) of

movement per day, the daily proportion of movement was much less than, for example,

in the case of wild horses or year-round pasture keeping. Thus, if no additional

movement incentives and possibilities are offered, the discharge husbandry system

doesn’t cover the movement needs of the horse despite separate functional areas

and a large outside discharge.

Additional movement is not only necessary to keep the musculoskeletal system and

bodily functions of the horse healthy, but also to ensure the horse’s well being and

mental balance.]
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5660
Permanent link to this record
 

 
Author Hoffmann, G.; Bockisch, F.-J.; Kreimeier, P.
Title Einfluss des Haltungssystems auf die Bewegungsaktivität und Stressbelastung bei Pferden in Auslaufhaltungssystemen Type Journal Article
Year 2009 Publication Landbauforschung – vTI Agriculture and Forestry Research Abbreviated Journal (up)
Volume 2 Issue 59 Pages 105-112
Keywords Bewegung, Cortisol, Herzfrequenzvariabilität (HFV), Pferd, Verhalten [movement, cortisol, heart rate variability (HRV), horse, behaviour]
Abstract Frühere Untersuchungen haben gezeigt, dass die tägliche Bewegung für die Gesunderhaltung der Pferde notwendig ist. Inwieweit sich jedoch unterschiedliche Bewegungsangebote auf das Stress-und Bewegungsverhalten von Pferden in einer Gruppen-Auslaufhaltung auswirken und ob der Bewegungsbedarf der Pferde durch eine Auslaufhaltung ohne zusätzliche Bewegung gedeckt werden kann, ist der Literatur bisher nicht zu entnehmen. Daher sollte in der nachfolgend beschriebenen Untersuchung der Frage nachgegangen werden, welche Auswirkungen verschiedene Bewegungsangebote auf die Bewegungsaktivität von Pferden in Gruppen-Auslaufhaltungen haben und ob diese das Wohlbefinden der Tiere beeinflussen. Letzteres wurde durch Messung der Herzfrequenzvariabilität und Bestimmung von Cortisolmetaboliten im Pferdekot erfasst und die Bewegungsaktivität der Pferde wurde mit ALT-Pedometern bestimmt.

Verglichen wurden eine Einzel-und Gruppenhaltung mit jeweils angrenzendem Auslauf, aber ohne eine zusätzliche Bewegung der Pferde außerhalb des Stalls. In drei weiteren Varianten der Gruppenhaltung bekamen die Pferde täglichen Auslauf auf einer unbegrünten Koppel, auf einer Weide oder durch gezielte Bewegung in einer Führanlage. Die Bewegungsaktivität konnte durch die zusätzliche Bewegung in Form von Weide oder Führanlage signifikant gesteigert werden.

Ein zusätzliches Bewegungsangebot führte bei den Pferden zu einer Abnahme der Stressbelastung und sollte auch den Pferden ermöglicht werden, die in einer Gruppenhaltung gehalten werden, um ihre physische und psychische Gesundheit zu erhalten.

[Former studies confirm the necessity of daily movement for the health of a horse. But so far no description could be found in the literature how different movement offerings impact the stress and movement behaviour of horses in group husbandries with close-by discharge. The same holds true for the question whether a discharge husbandry system can meet the movement requirements of horses if there isn&#65533;t any additional movement possibility. The aim of the present study was to examine different movement offerings, their effects on the movement activities of horses in a group horse husbandry with close-by discharge and the impact of the movement on the wellbeing of the animals.

The heart rate variability and the concentration of the cortisol metabolites in the horse excrement were analyzed for detecting the wellbeing of the horses. Additionally ALT-Pedometers were used for determining the movement activity.

A single and a group husbandry system, each with closeby discharge, were compared when horses had no additional movement outside the stable. In three further variants the group husbandry was supplemented with daily time on a non-grassy pasture land, a pasture or in a horse walker. Pasture or horse walker increased movement activity significantly. Nevertheless an additional movement offering resulted in a lower stress load of the horses and should also be allowed to horses in group husbandry systems to ensure the horse&#65533;s physical and mental health.]
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5661
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Author Horváth, G.; Blahó, M.; Kriska, G.; Hegedüs, R.; Gerics, B.; Farkas, R.; Åkesson, S.
Title An unexpected advantage of whiteness in horses: the most horsefly-proof horse has a depolarizing white coat Type Journal Article
Year 2010 Publication Proceedings of the Royal Society B: Biological Sciences Abbreviated Journal (up)
Volume 277 Issue 1688 Pages 1643-1650
Keywords
Abstract White horses frequently suffer from malign skin cancer and visual deficiencies owing to their high sensitivity to the ultraviolet solar radiation. Furthermore, in the wild, white horses suffer a larger predation risk than dark individuals because they can more easily be detected. In spite of their greater vulnerability, white horses have been highly appreciated for centuries owing to their natural rarity. Here, we show that blood-sucking tabanid flies, known to transmit disease agents to mammals, are less attracted to white than dark horses. We also demonstrate that tabanids use reflected polarized light from the coat as a signal to find a host. The attraction of tabanids to mainly black and brown fur coats is explained by positive polarotaxis. As the host's colour determines its attractiveness to tabanids, this parameter has a strong influence on the parasite load of the host. Although we have studied only the tabanid–horse interaction, our results can probably be extrapolated to other host animals of polarotactic tabanids, as the reflection–polarization characteristics of the host's body surface are physically the same, and thus not species-dependent.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5702
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Author Galef, G.G. Jr.
Title Social learning: promotor or inhibitor of innovation? Type Book Chapter
Year 2003 Publication Animal Intelligence Abbreviated Journal (up)
Volume Issue Pages
Keywords
Abstract
Address
Corporate Author Thesis
Publisher Oxford University Press Place of Publication Oxford Editor Reader, S.M.; Laland, K. N.
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5750
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Author Hoffmann, G.; Bentke, A.; Rose-Meierhöfer, S.; Berg, W.; Mazetti, P.; Hardarson, G.H.
Title Influence of an active stable system on the behavior and body condition of Icelandic horses Type Journal Article
Year 2012 Publication animal Abbreviated Journal (up)
Volume 6 Issue 10 Pages 1684-1693
Keywords activity, automatic feeding system, behavior, body condition score, Icelandic horse
Abstract Horses are often stabled in individual boxes, a method that does not meet their natural needs and may cause psychical and

musculoskeletal diseases. This problem is particularly evident in Iceland, where horses often spend the long winter periods in cramped

boxes. The aim of this study was to analyze the suitability of a group housing system in Iceland, but the results are also applicable to

horses of other regions. Eight Icelandic horses were observed in an active stable system, and their behavior and time budget were

recorded. Movement and lying behavior were studied with ALT (Activity, Lying, Temperature detection) pedometers. The effect of an

automatic concentrate feeding station (CFS) on the horses’ behavior was examined. In the first period of investigation, the horses

were fed concentrates manually, and in the second period, they were fed with the CFS. Additional behavioral observations and a

determination of social hierarchy occurred directly or by video surveillance. The physical condition of the horses was recorded by body

weight (BW) measurement and body condition scoring (BCS). The results showed a significant increase between the first and second

trial periods in both the activity (P,0.001) and the lying time (P50.003) of the horses with use of the CFS. However, there was no

significant change in BW during the first period without the CFS (P50.884) or during the second period with the CFS (P50.540).

The BCS of the horses was constant at a very good level during both trial periods, and the horses showed a low level of aggression, a

firm social hierarchy and behavioral synchronization. This study concludes that group housing according to the active stable principle is

a welfare-friendly option for keeping horses and is a suitable alternative to conventional individual boxes.
Address
Corporate Author Thesis
Publisher Cambridge Journals Online Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1751-732x ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5759
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Author Shen, Y.-Q.; Hebert, G.; Lin, L.-Y.; Luo, Y.-L.; Moze, E.; Li, K.-S.; Neveu, P.J.
Title Interleukine-1β and interleukine-6 levels in striatum and other brain structures after MPTP treatment: influence of behavioral lateralization Type Journal Article
Year 2005 Publication Journal of Neuroimmunology Abbreviated Journal (up)
Volume 158 Issue 1–2 Pages 14-25
Keywords N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Dopamine; Brain; Interleukin-6; Interleukin-1β; Behavioral lateralization
Abstract MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces diminution of the dopamine in nigrostriatal pathway and cognitive deficits in mice. MPTP treatment also increases pro-inflammatory cytokine production in substantia nigra and striatum. Since, pro-inflammatory cytokines influence striatal dopamine content and provoke cognitive impairments, the cognitive defects induced by MPTP may be partly due to brain cytokine induction in other structures than nigrostriatal pathway. Furthermore, behavioral lateralization, as assessed by paw preference, influences cytokine production at the periphery and in the central nervous system. Behavioral lateralization may thus influence brain cytokine levels after MPTP. In order to address these issues, mice selected for paw preference were injected with 25 mg/kg MPTP i.p. for five consecutive days after which striatal dopamine and DOPAC contents were measured by HPLC and IL-1&#946; and IL-6 quantified by ELISA in the striatum, cerebral cortex, hippocampus and hypothalamus. The results showed that MPTP treatment induced dramatic loss of DA in striatum, simultaneously, IL-6 levels decreased in the striatum and increased in hippocampus and hypothalamus, while IL-1&#946; levels decreased in the striatum, cerebral cortex and hippocampus. Interestingly, striatal dopamine turnover under basal conditions as well as striatal IL-1&#946; and IL-6 levels under basal conditions and after MPTP depended on behavioral lateralization. Left pawed mice showed a higher decrease in dopamine turnover and lower cytokine levels as compared to right pawed animals. Behavioral lateralization also influenced IL-6 hippocampal levels under basal conditions and IL-1&#946; cortical levels after MPTP. From these results, it can be concluded that MPTP-induced cognitive defects are accompanied by an alteration of pro-inflammatory cytokine levels in brain structures other than those involved in the nigrostriatal pathway. In addition, MPTP-induced dopamine decrease is influenced by behavioral lateralization, possibly through an effect on brain cytokine levels.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0165-5728 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5781
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Author Quaranta, A.; Siniscalchi, M.; Frate, A.; Vallortigara, G.
Title Paw preference in dogs: relations between lateralised behaviour and immunity Type Journal Article
Year 2004 Publication Behavioural Brain Research Abbreviated Journal (up)
Volume 153 Issue 2 Pages 521-525
Keywords Paw preference; Lateralisation; Immunity; Dog
Abstract Paw use in a task consisting of the removal of a piece of adhesive paper from the snout was investigated in 80 mongrel and pure-bred domestic dogs (Canis familiaris). Population lateralisation was observed, but in opposite directions in the two sexes (animals were not desexed): males preferentially used their left paw, females their right paw. The relationship between immune function and paw preference was then investigated. Some immune parameters (total number of white blood cells including lymphocytes, granulocytes and monocytes; leukocyte formula; total proteins; &#947;-globulins) were investigated in a sample of left-pawed (n=6), right-pawed (n=6) and ambidextrous (n=6) dogs. The results showed that the percentage of lymphocytes was higher in left-pawed than in right-pawed and ambidextrous dogs, whereas granulocytes percentage was lower in left-pawed than in right-pawed and ambidextrous dogs. Moreover, total number of lymphocytes cells was higher in left-pawed than in right-pawed and ambidextrous dogs, whereas the number of &#947;-globulins was lower in left-pawed than in right-pawed and ambidextrous dogs. These findings represent the first evidence that brain asymmetry modulates immune responses in dogs.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0166-4328 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5783
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Author Siniscalchi, M.; Sasso, R.; Pepe, A.M.; Dimatteo, S.; Vallortigara, G.; Quaranta, A.
Title Catecholamine plasma levels following immune stimulation with rabies vaccine in dogs selected for their paw preferences Type Journal Article
Year 2010 Publication Neuroscience Letters Abbreviated Journal (up)
Volume 476 Issue 3 Pages 142-145
Keywords Physiology; Behavior; Lateralization; Catecholamines; Paw preference; Neuro-immune-modulation
Abstract Epinephrine and norepinephrine plasma levels were assessed in dogs in relation to paw preference following an immune challenge with rabies vaccine. The results showed that both catecholamines increased after the vaccine administration, confirming the main role of the sympathetic nervous system in the modulation activity between the brain and the immune system. Moreover, ambidextrous dogs showed a significantly higher increase of epinephrine levels 8 days after immunization with respect to right- and left-pawed dogs, suggesting that the biological activity of this molecule could be key for a different immune response with regard to laterality.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0304-3940 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number Equine Behaviour @ team @ Serial 5788
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