Records |
Author |
Schmoldt, A.; Benthe, H.F.; Haberland, G. |
Title |
Digitoxin metabolism by rat liver microsomes |
Type |
Journal Article |
Year |
1975 |
Publication |
Biochemical pharmacology |
Abbreviated Journal |
Biochem Pharmacol |
Volume |
24 |
Issue |
17 |
Pages |
1639-1641 |
Keywords |
Animals; Chromatography, Thin Layer; Digitoxigenin/metabolism; Digitoxin/*metabolism; Hydroxylation; Male; Microsomes, Liver/*metabolism; NADP/metabolism; Rats; Time Factors |
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English |
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ISSN |
0006-2952 |
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Notes |
PMID:10 |
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no |
Call Number |
Admin @ knut @ |
Serial |
20 |
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Author |
Jallon, J.M.; Risler, Y.; Iwatsubo, M. |
Title |
Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH |
Type |
Journal Article |
Year |
1975 |
Publication |
Biochemical and biophysical research communications |
Abbreviated Journal |
Biochem Biophys Res Commun |
Volume |
67 |
Issue |
4 |
Pages |
1527-1536 |
Keywords |
Animals; Cattle; Glutamate Dehydrogenase/*metabolism; Ketoglutaric Acids; Kinetics; Liver/*enzymology; Nadp; Oxidation-Reduction; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet |
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English |
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Edition |
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ISSN |
0006-291X |
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Notes |
PMID:1038 |
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no |
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Admin @ knut @ |
Serial |
21 |
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Author |
Rodier, F. |
Title |
[Spectral properties of porcine plasminogen: study of the acidic transition (author's transl)] |
Type |
Journal Article |
Year |
1976 |
Publication |
European journal of biochemistry / FEBS |
Abbreviated Journal |
Eur J Biochem |
Volume |
63 |
Issue |
2 |
Pages |
553-562 |
Keywords |
Animals; Binding Sites; Guanidines; Hydrogen-Ion Concentration; *Plasminogen; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Swine; Temperature |
Abstract |
The acidic transition of porcine plasminogen, prepared by affinity chromatography, was studied by non-destructive methods. These methods are based on the analysis of the behaviour of the tryptophyls under various conditions. The perturbation of the absorption and emission spectra by pH or temperature and the dynamic quenching of the intrinsic fluorescence are used to obtain information on structural changes which affect the environment of these residues. It is shown that by decreasing pH the fluorescence emission spectra are shifted toward the long wavelengths, with a broadening of the fluorescence band. The same effect can be obtained at constant pH by heating the protein solution. In order to analyze these phenomena, it is assumed that the fluorescence intensities at 355 nm and 328 nm reflect the proportion of the tryptophans which are exposed to the solvent, and buried, respectively. The plot of the ratio of the fluorescence intensities at these wavelengths versus pH or temperature leads to a titration curve showing an unmasking of tryptophans. The proportion of exposed tryptophans is measured by the dynamic fluorescence quenching technique and the data analyzed according to Lehrer. The plot of the fraction of exposed tryptophyls versus pH also shows the unmasking of these chromophores. Thermal perturbation of a solution of plaminogen at neutral pH induces a difference absorption spectrum whose amplitudes at the maxima are proportional to the number of exposed aromatic residues. The comparison with a solution of fully denatured plasminogen in 6 M guanidium chloride, where all the tryptophyls are exposed, shows that the percentage of exposure is equal to 59%. This number is significantly higher than the percentage found by the fluorescence quenching technique (20%), indicating that some tryptophyls are located in crevices, exposed to the solvent but not to the iodide. At acidic pH the absorption difference spectra induced by thermal perturbation are not classical, since they show an inversion and a new band between 300 nm and 305 nm. This band is mentioned in the literature as a minor band of tryptophan which appears when this chromophore is located in an asymmetric environment. On plotting the maximum amplitude of these spectra obtained at acidic pH versus temperature, we obtain a curve indicating that two types of antagonistic interactions are involved in the perturbation of the chromophores spectra. The spectrophotometric titration of plasminogen gives classical absorption difference spectra. By plotting the maximum amplitude at 292 nm versus pH, we obtain a titration curve with an apparent pK of 2.9 units. This pK is acidic which respect to the pK value of a normal carboxyl. This low value can be due to a positively charged group in the neighbourhood of a carboxyl, which interacts with one or more chromophores. When the carboxyl becomes protonated, this positively charged group is free and available to perturb the environment of some chromophores... |
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Language |
French |
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Original Title |
Proprietes spectrales du plasminogene porcin. Etude de la transition acide |
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Edition |
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ISSN |
0014-2956 |
ISBN |
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Conference |
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Notes |
PMID:4326 |
Approved |
no |
Call Number |
Admin @ knut @ |
Serial |
22 |
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Author |
Turpeinen, O. |
Title |
Effect of cholesterol-lowering diet on mortality from coronary heart disease and other causes |
Type |
Journal Article |
Year |
1979 |
Publication |
Circulation |
Abbreviated Journal |
Circulation |
Volume |
59 |
Issue |
1 |
Pages |
1-7 |
Keywords |
Coronary Disease/blood/*mortality/prevention & control; Dairy Products; *Dietary Fats; *Fats, Unsaturated; Finland; Humans; Hypercholesterolemia/complications/*diet therapy/mortality; Male; Middle Aged; Neoplasms/mortality |
Abstract |
International statistics indicate that there is a close correlation between the consumption of saturated fats (dairy fats and meat fats) and the mortality from coronary heart disease (CHD), and this conception has been confirmed by many epidemiological studies. Such studies alone, however, cannot prove the existence of a cause-and-effect relationship between these two variables; dietary intervention trials are needed. The Finnish Mental Hospital Study was such a trial, conducted in two hospitals near Helsinki in 1959--1971. Practically total replacement of dairy fats by vegetable oils in the diets of these hospitals was followed by a substantial reduction in the mortality of men from CHD. Total mortality also appeared to be reduced. As to the causes of death other than CHD, none was significantly influenced by dietary change. This was also true for malignant neoplasms. To alleviate the burden of CHD on public health, many investigators have recommended important changes in the quantity and quality of dietary fats. |
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ISSN |
0009-7322 |
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Notes |
PMID:758101 |
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no |
Call Number |
refbase @ user @ |
Serial |
33 |
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Author |
Houpt, K.A. |
Title |
New perspectives on equine stereotypic behaviour |
Type |
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Year |
1995 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
Volume |
27 |
Issue |
2 |
Pages |
82-83 |
Keywords |
Animals; Horses/*psychology; Stereotyped Behavior/*physiology |
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ISSN |
0425-1644 |
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Notes |
PMID:7607153 |
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no |
Call Number |
refbase @ user @ |
Serial |
34 |
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Author |
Krzeminska, W. |
Title |
[The child learns about the world] |
Type |
Journal Article |
Year |
1979 |
Publication |
Pielegniarka i polozna |
Abbreviated Journal |
Pieleg Polozna |
Volume |
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Issue |
7 |
Pages |
24-25 |
Keywords |
Child; *Child Development; Child, Preschool; Humans; *Learning |
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Polish |
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Original Title |
Dziecko poznaje swiat |
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ISSN |
0048-4148 |
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Notes |
PMID:260249 |
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no |
Call Number |
refbase @ user @ |
Serial |
43 |
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Author |
Houpt, K.A. |
Title |
Stable vices and trailer problems |
Type |
Journal Article |
Year |
1986 |
Publication |
The Veterinary clinics of North America. Equine practice |
Abbreviated Journal |
Vet Clin North Am Equine Pract |
Volume |
2 |
Issue |
3 |
Pages |
623-633 |
Keywords |
Aerophagy/veterinary; Aggression; Animals; *Animals, Domestic; *Behavior, Animal; Fear; Frustration; Habits; *Horses; Locomotion; Mastication; Social Environment; Transportation |
Abstract |
Stable vices include oral vices such as cribbing, wood chewing, and coprophagia, as well as stall walking, weaving, pawing, and stall kicking. Some of these behaviors are escape behaviors; others are forms of self-stimulation. Most can be eliminated by pasturing rather than stall confinement. Trailering problems include failure to load, scrambling in the moving trailer, struggling in the stationary trailer, and refusal to unload. Gradual habituation to entering the trailer, the presence of another horse, or a change in trailer type can be used to treat these problems. |
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Edition |
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ISSN |
0749-0739 |
ISBN |
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Notes |
PMID:3492249 |
Approved |
no |
Call Number |
refbase @ user @ |
Serial |
48 |
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Author |
Crowell-Davis, S.L.; Houpt, K.A. |
Title |
Maternal behavior |
Type |
Journal Article |
Year |
1986 |
Publication |
The Veterinary clinics of North America. Equine practice |
Abbreviated Journal |
Vet Clin North Am Equine Pract |
Volume |
2 |
Issue |
3 |
Pages |
557-571 |
Keywords |
Aggression; Animals; Animals, Wild; Female; *Horses; Lactation; *Maternal Behavior; Pregnancy; *Pregnancy, Animal; Rejection (Psychology) |
Abstract |
Parturition in mares is rapid and is followed by a brief period of sensitivity to imprinting on a foal. There is large individual variation in normal maternal style, but normal mothers actively defend their foal, remain near the foal when it is sleeping, tolerate or assist nursing, and do not injure their own foal. Disturbance of a mare and foal during the early imprinting period can predispose a mare to rejection of her foal; therefore, it should be avoided. There are a variety of forms of foal rejection and numerous etiologies. Therefore, each case should be evaluated individually. |
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ISSN |
0749-0739 |
ISBN |
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Notes |
PMID:3492245 |
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no |
Call Number |
refbase @ user @ |
Serial |
49 |
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Author |
Crowell-Davis, S.L.; Houpt, K.A. |
Title |
Techniques for taking a behavioral history |
Type |
Journal Article |
Year |
1986 |
Publication |
The Veterinary clinics of North America. Equine practice |
Abbreviated Journal |
Vet Clin North Am Equine Pract |
Volume |
2 |
Issue |
3 |
Pages |
507-518 |
Keywords |
Animals; *Behavior, Animal; Cooperative Behavior; *Horses; Maternal Behavior |
Abstract |
A thorough behavioral history is essential for adequate assessment of a given case. In reviewing the chief complaint, a description of what actually happened, rather than the owner's interpretation of what happened, is required. Other behavior problems, environment, rearing history, and training need to be reviewed. Sample question sets for some common problems are given. |
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0749-0739 |
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Notes |
PMID:3492242 |
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no |
Call Number |
refbase @ user @ |
Serial |
50 |
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Author |
Youket, R.J.; Carnevale, J.M.; Houpt, K.A.; Houpt, T.R. |
Title |
Humoral, hormonal and behavioral correlates of feeding in ponies: the effects of meal frequency |
Type |
Journal Article |
Year |
1985 |
Publication |
Journal of animal science |
Abbreviated Journal |
J. Anim Sci. |
Volume |
61 |
Issue |
5 |
Pages |
1103-1110 |
Keywords |
Animals; Behavior, Animal/physiology; Blood Glucose/*analysis; Blood Proteins/*analysis; Blood Volume; *Eating; Feeding Behavior/physiology; Female; Heart Rate; Horses/blood/*physiology; Male; Osmolar Concentration; Osmotic Pressure; Triiodothyronine/*blood |
Abstract |
The effect of meal frequency on body fluid, glucose, triiodothyronine (T3), heart rate and behavior was measured in 10 ponies. A simple reversal design was used in which each pony received one meal/day (1X) for 2 wk and six meals/day (6X) for 2 wk. The total intake/day was held constant. Feeding was followed by a rise in plasma levels of glucose, T3, protein and osmolality. One large meal was followed by significantly greater changes in all of the variables than was a meal one-sixth the size. Plasma T3 rose from 41 +/- 5 (SE) ng/liter before feeding to 43 +/- 5 ng/liter following a small meal, but rose significantly higher, from 39 +/- 4 to 60 +/- 10 ng/liter, following a large meal. Glucose rose from 84 +/- 3 to 109 +/- 7 mg/dl following a small meal and rose significantly higher, from 83 +/- 3 to 154 +/- 11 mg/dl, after a large meal. Plasma protein rose from 6.55 +/- .14 to 6.62 +/- .16 g/dl following a small meal and from 6.45 +/- .14 to 6.99 +/- .11 g/dl following a large meal. Osmolality rose from 227 +/- 1 mosmol/liter before to 279 +/- 1 mosmol/liter following a small meal and significantly higher from 278 +/- 2 to 285 +/- 1 mosnol/liter following a large meal. Heart rate rose from 42 beats/min in the absence of feed to 50 beats/min when food was visible to the ponies and did not rise higher when eating began. There were no significant differences in the cardiac response to one large meal and that to a small meal.(ABSTRACT TRUNCATED AT 250 WORDS) |
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0021-8812 |
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PMID:4077755 |
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no |
Call Number |
refbase @ user @ |
Serial |
51 |
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