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Miller-Butterworth, C.M.; Kaplan, J.R.; Barmada, M.M.; Manuck, S.B.; Ferrell, R.E. |
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Title |
The Serotonin Transporter: Sequence Variation in Macaca fascicularis and its Relationship to Dominance |
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Year |
2007 |
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Abbreviated Journal |
Behav Genet |
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Specific genotypes of the rhesus monkey and human serotonin transporter gene (SERT) promoter region are associated with personality traits and serotonergic activity. However, the most commonly studied promoter polymorphism (5-HTTLPR) is monomorphic in many other monkey species. To date, no systematic search for alternative potentially functional polymorphisms across the remaining coding parts of the gene has been undertaken in other primate species, despite the crucial role SERT plays in modulating serotonergic tone. We investigated whether sequence variation in this gene is associated with social rank and serotonin metabolite (5-HIAA) differences in 524 cynomolgus macaques. Sequence variation and extent of linkage disequilibrium (LD) across the regulatory and coding regions were initially characterized in 92 macaques. The exons and promoter contained 28 polymorphisms, more than double that recorded for human SERT. In further contrast to humans, the macaque SERT showed no significant LD. Potentially functional polymorphisms were genotyped in all animals. No individual variants or haplotypes were significantly associated with social rank or 5-HIAA concentrations; however, certain serotonin transporter diplotypes may modulate acquisition of dominance status. |
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Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, A300 Crabtree Hall, 130 De Soto Street, Pittsburgh, PA, USA, cbutterworth@hgen.pitt.edu |
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0001-8244 |
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PMID:17605101 |
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Equine Behaviour @ team @ |
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4104 |
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Author |
Morley, K.I.; Montgomery, G.W. |
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Title |
The genetics of cognitive processes: candidate genes in humans and animals |
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Journal Article |
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Year |
2001 |
Publication |
Behavior Genetics |
Abbreviated Journal |
Behav Genet |
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31 |
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6 |
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511-531 |
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Keywords |
Animals; *Chromosome Mapping; Drosophila melanogaster; Genetic Markers/*genetics; Humans; Intelligence/*genetics; Mental Retardation/genetics; Mice; Phenotype; Quantitative Trait, Heritable |
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It has been hypothesized that numerous genes contribute to individual variation in human cognition. An extensive search of the scientific literature was undertaken to identify candidate genes which might contribute to this complex trait. A list of over 150 candidate genes that may influence some aspect of cognition was compiled. Some genes are particularly strong candidates based on evidence for involvement in cognitive processes in humans, mice, and Drosophila melanogaster. This survey confirms that many genes are associated with cognitive variation and highlights the potential importance of animal models in the study of human cognition. |
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Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia |
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0001-8244 |
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PMID:11838530 |
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Equine Behaviour @ team @ |
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4141 |
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Bouchard, T.J.J.; Loehlin, J.C. |
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Title |
Genes, evolution, and personality |
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Journal Article |
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Year |
2001 |
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Behavior Genetics |
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Behav Genet |
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31 |
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3 |
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243-273 |
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Animals; *Evolution; Genetics, Behavioral; Humans; Individuality; Personality/*genetics; Twin Studies |
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There is abundant evidence, some of it reviewed in this paper, that personality traits are substantially influenced by the genes. Much remains to be understood about how and why this is the case. We argue that placing the behavior genetics of personality in the context of epidemiology, evolutionary psychology, and neighboring psychological domains such as interests and attitudes should help lead to new insights. We suggest that important methodological advances, such as measuring traits from multiple viewpoints, using large samples, and analyzing data by modern multivariate techniques, have already led to major changes in our view of such perennial puzzles as the role of “unshared environment” in personality. In the long run, but not yet, approaches via molecular genetics and brain physiology may also make decisive contributions to understanding the heritability of personality traits. We conclude that the behavior genetics of personality is alive and flourishing but that there remains ample scope for new growth and that much social science research is seriously compromised if it does not incorporate genetic variation in its explanatory models. |
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Department of Psychology. University of Minnesota, Minneapolis 55455, USA. bouch001@tc.umn.edu |
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0001-8244 |
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PMID:11699599 |
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Call Number |
Equine Behaviour @ team @ |
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4142 |
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Author |
Weiss, A.; King, J.E.; Figueredo, A.J. |
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Title |
The heritability of personality factors in chimpanzees (Pan troglodytes) |
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Journal Article |
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Year |
2000 |
Publication |
Behavior Genetics |
Abbreviated Journal |
Behav Genet |
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30 |
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3 |
Pages |
213-221 |
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Keywords |
Animals; Female; Humans; Male; Models, Genetic; Pan troglodytes/*genetics; Personality/*genetics; Social Environment |
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Human personality and behavior genetic studies have resulted in a growing consensus that five heritable factors account for most variance in human personality. Prior research showed that chimpanzee personality is composed of a dominance-related factor and five human-like factors--Surgency, Dependability, Emotional Stability, Agreeableness, and Openness. Genetic, shared zoo, and nonshared environmental variance components of the six factors were estimated by regressing squared phenotypic differences of all possible pairs of chimpanzees onto 1 – Rij, where Rij equals the degree of relationship and a variable indicating whether the pair was housed in the same zoo. Dominance showed significant narrow-sense heritability. Shared zoo effects accounted for only a negligible proportion of the variance for all factors. |
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Department of Psychology, University of Arizona, Tucson 85721, USA. aweiss@u.arizona.edu |
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0001-8244 |
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PMID:11105395 |
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Equine Behaviour @ team @ |
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4143 |
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Author |
Boice, R. |
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Title |
Behavioral comparability of wild and domesticated rats |
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Journal Article |
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Year |
1981 |
Publication |
Behavior Genetics |
Abbreviated Journal |
Behav Genet |
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Volume |
11 |
Issue |
5 |
Pages |
545-553 |
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Keywords |
Animals; *Behavior, Animal; Female; Genetics, Behavioral; Intelligence; Learning; Male; Rats/*genetics |
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The oft-repeated concern for the lack of behavioral comparability of domestic rats with wild forms of Rattus norvegicus is unfounded. Laboratory rats appear to show the potential for all wild-type behaviors, including the most dramatic social postures. Moreover, domestics are capable of assuming a feral existence without difficulty, one where they readily behave in a fashion indistinguishable from wild rats. The one behavioral difference that is clearly established concerns performance in laboratory learning paradigms. The superiority of domestics in these laboratory tasks speaks more to quieting the concerns of degeneracy theorists than to problems of using domestic Norway rats as subjects representative of their species. |
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0001-8244 |
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PMID:7325955 |
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Equine Behaviour @ team @ |
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4144 |
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