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Author |
Houpt, T.R.; Houpt, K.A. |
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Title |
Nitrogen conservation by ponies fed a low -protein ration |
Type |
Journal Article |
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Year |
1971 |
Publication |
American journal of veterinary research |
Abbreviated Journal |
Am J Vet Res |
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Volume |
32 |
Issue |
4 |
Pages |
579-588 |
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Keywords |
Administration, Oral; Amino Acids/biosynthesis; Animals; Anti-Infective Agents/pharmacology; Body Weight/drug effects; Dietary Proteins/*pharmacology; Horses/*metabolism; Nitrogen/*metabolism; Urea/administration & dosage/antagonists & inhibitors/metabolism; Water/metabolism |
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ISSN |
0002-9645 |
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Notes |
PMID:5110116 |
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no |
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Call Number |
refbase @ user @ |
Serial |
62 |
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Author |
Alexander, F. |
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Title |
Effect of phenylbutazone on electrolyte metabolism in ponies |
Type |
Journal Article |
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Year |
1982 |
Publication |
The Veterinary record |
Abbreviated Journal |
Vet. Rec. |
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Volume |
110 |
Issue |
12 |
Pages |
271-272 |
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Keywords |
Animals; Chlorides/metabolism; Electrolytes/*metabolism; Horses/*metabolism; Male; Phenylbutazone/*pharmacology; Sodium/metabolism |
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Abstract |
Phenylbutazone administered in therapeutic doses to ponies decreased urinary sodium and chloride excretion. The volume and osmolality of the urine was unaffected as was potassium excretion. Faecal excretion of chloride decreased and that of potassium increased, while faecal sodium excretion was unaffected. Plasma pH, bicarbonate and total carbon dioxide decreased after phenylbutazone administration. Packed cell volume, plasma sodium, potassium, carbon dioxide tension and chloride were unchanged. |
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ISSN |
0042-4900 |
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Notes |
PMID:7080416 |
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no |
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Call Number |
refbase @ user @ |
Serial |
109 |
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Author |
Alexander, F. |
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Title |
The effect of some anti-diarrhoeal drugs on intestinal transit and faecal excretion of water and electrolytes in the horse |
Type |
Journal Article |
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Year |
1978 |
Publication |
Equine veterinary journal |
Abbreviated Journal |
Equine Vet J |
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Volume |
10 |
Issue |
4 |
Pages |
229-234 |
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Keywords |
Animals; Antidiarrheals/*pharmacology; Atropine/pharmacology; Electrolytes/*analysis/urine; Feces/*analysis; Gastrointestinal Motility/*drug effects; Horses/*metabolism/physiology; Loperamide/pharmacology; Male; Meperidine/pharmacology; Morphine/pharmacology; Opium/pharmacology; Water/*analysis |
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Abstract |
The effect of morphine, Tinct. opii, loperamide, pethidine and atropine on intestinal transit and the faecal and urinary excretion of water and electrolytes was studied in ponies. The rate of passage of a particulate marker was slowed by morphine, hastened then slowed by loperamide and Tinct. opii, and hastened by atropine. The liquid marker was slowed by Tinct. opii and hastened then slowed by the other drugs. Only loperamide decreased the faecal sodium excretion. This drug also decreased faecal water and weight; it appeared worthy of clinical trial in diarrhoea. Tinct. opii decreased by morphine, pethidine and atropine increased faecal water. |
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ISSN |
0425-1644 |
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Notes |
PMID:738263 |
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no |
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Call Number |
refbase @ user @ |
Serial |
110 |
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Author |
Alexander, F.; Collett, R.A. |
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Title |
Proceedings: Some observations on the pharmacokinetics of trimethoprim in the horse |
Type |
Journal Article |
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Year |
1974 |
Publication |
British journal of pharmacology |
Abbreviated Journal |
Br J Pharmacol |
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Volume |
52 |
Issue |
1 |
Pages |
142p |
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Keywords |
Animals; Half-Life; Horses/*metabolism; Kinetics; Trimethoprim/*metabolism |
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English |
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ISSN |
0007-1188 |
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Notes |
PMID:4451793 |
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no |
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Call Number |
refbase @ user @ |
Serial |
112 |
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Author |
Alexander, F.; Collett, R.A. |
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Title |
Pethidine in the horse |
Type |
Journal Article |
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Year |
1974 |
Publication |
Research in veterinary science |
Abbreviated Journal |
Res Vet Sci |
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Volume |
17 |
Issue |
1 |
Pages |
136-137 |
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Keywords |
Animals; Half-Life; Horses/*metabolism; Injections, Intravenous/veterinary; Male; Meperidine/administration & dosage/analysis/*metabolism/pharmacology |
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ISSN |
0034-5288 |
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Notes |
PMID:4421117 |
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no |
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Call Number |
refbase @ user @ |
Serial |
113 |
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Author |
Alexander, F.; Davies, M.E. |
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Title |
Studies on vitamin B12 in the horse |
Type |
Journal Article |
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Year |
1969 |
Publication |
The British veterinary journal |
Abbreviated Journal |
Br. Vet. J. |
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Volume |
125 |
Issue |
4 |
Pages |
169-176 |
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Keywords |
Animals; Biological Assay; Cattle; Chickens; Feces/analysis; Horses/*metabolism; Humans; Lactobacillus/metabolism; Rabbits; Rats; Sheep; Urine/analysis; Vitamin B 12/*analysis |
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ISSN |
0007-1935 |
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Notes |
PMID:5814055 |
Approved |
no |
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Call Number |
refbase @ user @ |
Serial |
116 |
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Author |
Weik, H.; Lingk, W.; Altmann, H.J. |
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Title |
[Behavior of individual fatty acids during in-vitro lipolysis and resynthesis in equine depot fat] |
Type |
Journal Article |
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Year |
1972 |
Publication |
Zentralblatt fur Veterinarmedizin. Reihe A |
Abbreviated Journal |
Zentralbl Veterinarmed A |
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Volume |
19 |
Issue |
8 |
Pages |
677-685 |
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Keywords |
Adipose Tissue/*metabolism; Animals; Fatty Acids/*metabolism; Fatty Acids, Nonesterified/metabolism; Horses/*metabolism; Triglycerides/metabolism |
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Language |
German |
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Original Title |
Das Verhalten der einzelnen Fettsauren wahrend der Lipolyse und Resynthese im Pferdepotfett in vitro |
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ISSN |
0514-7158 |
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Notes |
PMID:4628723 |
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no |
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Call Number |
refbase @ user @ |
Serial |
131 |
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Author |
Weik, H.; Altmann, H.J. |
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Title |
[Behavior of blood lipids during fasting in the horse] |
Type |
Journal Article |
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Year |
1971 |
Publication |
Zentralblatt fur Veterinarmedizin. Reihe A |
Abbreviated Journal |
Zentralbl Veterinarmed A |
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Volume |
18 |
Issue |
2 |
Pages |
131-138 |
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Keywords |
Adipose Tissue/metabolism; Animals; Chromatography, Gas; Fasting/*veterinary; Fatty Acids/blood/metabolism; Fatty Acids, Nonesterified/blood; Horses/*metabolism; Lipids/*blood |
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Language |
German |
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Original Title |
Das Verhalten einiger Blutlipide wahrend des Hungerns beim Pferd |
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0514-7158 |
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Notes |
PMID:4995835 |
Approved |
no |
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Call Number |
refbase @ user @ |
Serial |
134 |
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Author |
Bottoms, G.D.; Roesel, O.F.; Rausch, F.D.; Akins, E.L. |
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Title |
Circadian variation in plasma cortisol and corticosterone in pigs and mares |
Type |
Journal Article |
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Year |
1972 |
Publication |
American Journal of Veterinary Research |
Abbreviated Journal |
Am J Vet Res |
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Volume |
33 |
Issue |
4 |
Pages |
785-790 |
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Keywords |
Animals; *Circadian Rhythm; Corticosterone/*blood; Female; Horses/*metabolism; Hydrocortisone/*blood; Methods; Swine/*metabolism; Time Factors |
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English |
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ISSN |
0002-9645 |
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Notes |
PMID:5017871 |
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no |
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Call Number |
Equine Behaviour @ team @ |
Serial |
4074 |
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Author |
Dirikolu, L.; Lehner, A.F.; Karpiesiuk, W.; Hughes, C.; Woods, W.E.; Boyles, J.; Harkins, J.D.; Troppmann, A.; Tobin, T. |
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Title |
Detection, quantification, metabolism, and behavioral effects of selegiline in horses |
Type |
Journal Article |
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Year |
2003 |
Publication |
Veterinary Therapeutics : Research in Applied Veterinary Medicine |
Abbreviated Journal |
Vet Ther |
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Volume |
4 |
Issue |
3 |
Pages |
257-268 |
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Keywords |
Administration, Oral; Animals; Behavior, Animal/drug effects; Female; Horses/*metabolism; Mass Spectrometry/veterinary; Monoamine Oxidase Inhibitors/administration & dosage/blood/*pharmacokinetics/pharmacology/urine; Selegiline/administration & dosage/blood/*pharmacokinetics/pharmacology/urine; Substance Abuse Detection/veterinary |
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Abstract |
Selegiline ([R]-[-]N,alpha-dimethyl-N-2- propynylphenethylamine or l-deprenyl), an irreversible inhibitor of monoamine oxidase, is a classic antidyskinetic and antiparkinsonian agent widely used in human medicine both as monotherapy and as an adjunct to levodopa therapy. Selegiline is classified by the Association of Racing Commissioners International (ARCI) as a class 2 agent, and is considered to have high abuse potential in racing horses. A highly sensitive LC/MS/MS quantitative analytical method has been developed for selegiline and its potential metabolites amphetamine and methamphetamine using commercially available deuterated analogs of these compounds as internal standards. After administering 40 mg of selegiline orally to two horses, relatively low (<60 ng/ml) concentrations of parent selegiline, amphetamine, and methamphetamine were recovered in urine samples. However, relatively high urinary concentrations of another selegiline metabolite were found, tentatively identified as N- desmethylselegiline. This metabolite was synthesized and found to be indistinguishable from the new metabolite recovered from horse urine, thereby confirming the chemical identity of the equine metabolite. Additionally, analysis of urine samples from four horses dosed with 50 mg of selegiline confirmed that N-desmethylselegiline is the major urinary metabolite of selegiline in horses. In related behavior studies, p.o. and i.v. administration of 30 mg of selegiline produced no significant changes in either locomotor activities or heart rates. |
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Address |
Department of Biomedical Sciences, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, Tuskegee, AL 36088, USA |
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Series Issue |
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Edition |
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ISSN |
1528-3593 |
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Notes |
PMID:15136987 |
Approved |
no |
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Call Number |
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Serial |
1901 |
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